Tumor Induction by Murine Sarcoma Virus in Akr and C58 Mice

Abstract

A c o m m o n f e a t u r e of a v i a n a n d m a m m a l i a n s a r c o m a viruses is t h e i n d u c t i o n of soft t i s s u e s a r c o m a s w h i c h are c h a r a c t e r i z e d in t h e species of origin b y a very s h o r t l a t e n t p e r i o d a n d b y a high f r e q u e n c y of c o m p l e t e s p o n t a n e o u s regressions. T h i s u n i q u e p r o p e r t y is not s h a r e d by a n y o t h e r oncogenic agents, e i t h e r viral or c h e m i c a l in n a t u r e , since the t u m o r s t h e y i n d u c e u s u a l l y arise after weeks or m o n t h s a n d show a f a t a l progressive growth.

Relationship between moloney MSV tumor resistance and endogenous virogene expression in AKR mouse strain and its hybrids

“…Interference of M-MSV focus formation by MuLVs has been described under well-defined in vitro conditions (Sarma er a/., 1967), but an extension of this concept to explain what really happens in vivo is not feasible. The lack of M-MSV tumor resistance in adult AKR mice preinfected as newborns with M-MuLV (Chieco-Bianchi et al, 1974) is not consistent with this possibility. Alternatively, a cross-reacting natural immunity might contribute to this phenomenon (Ihle et al, 1976).…”

Genetic control of oncogenesis by murine sarcoma virus moloney pseudotype. I. Genetics of resistance in AKR mice

“…The Moloney isolate of MSV (M-MSV) (Moloney, 1966) induces rapidly developing tumors (5-10 days' latency) which have a very high incidence of spontaneous regression in adult normal mice (Fefer et al, 1967). We had previously observed (Chieco-Bianchi et al, 1974) that, following M-MSV injection, adult AKR mice showed a high incidence of progressing tumors due to the formation of a new pseudotype with the endogenous Gross MuLV. Moreover, adult AKR mice exhibited a very strong initial resistance to M-MSV tumor development as indicated by the prolonged latent period observed (1-2 months).…”