Tumor‐induced osteomalacia in an adolescent with an undifferentiated embryonal sarcoma of the liver

Olivas-Mazón, Raquel; Martín-Cazaña, María; Pérez-Mohand, Patricia; Garzón-Lorenzo, Lucía; Espino-Hernández, M.; Baro-Fernández, María; Pérez‐Alonso, Vanesa

doi:10.1002/pbc.28386

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…As stated previously, it is associated with benign mesenchymal tumors in the vast majority of cases, approximately 90% ( 3). Yet, it is well-documented that malignant tumors, most notably sarcomas, also have the capacity to induce this condition (15)(16)(17)(18) In cases lacking an initial biopsy, as in the patient under discussion, it becomes challenging to conclusively determine the tumor's original nature. It remains uncertain whether the initial tumor was benign and subsequently underwent malignant transformation, or if the neoplasm was inherently sarcomatous.…”

Section: Discussionmentioning

confidence: 99%

Transformation of a Long-Standing Phosphaturic Tumor Inducing Osteomalacia into Malignancy

Malagon-Rangel,

Gabriel-Solis,

Zavala-Jonguitud

et al. 2023

Preprint

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Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, which leads to deranged bone turnover. TIO is usually associated with benign mesenchymal tumors, although it has also been reported in malignant tumors. We report the case of a 56-year-old individual who presented with a long clinical course of hypophosphatemia, weakness, and kyphosis, associated with a tumor in the foot. After several years, this lesion exhibited malignant behavior and was diagnosed as a high-grade sarcoma. To date, this case is among the 10 reported cases in the literature of a mesenchymal tumor associated with TIO undergoing malignant transformation. This report underscores the importance of a comprehensive evaluation of patients with unexplained hypophosphatemia, and highlights the need for diligent follow-up to detect possible malignant transformation of the underlying tumor. Clinicians should consider TIO in the differential diagnosis of hypophosphatemia, and promptly investigate for the presence of an underlying tumor, as early detection may improve the patient's prognosis.

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Section: Discussionmentioning

confidence: 99%

Transformation of a Long-Standing Phosphaturic Tumor Inducing Osteomalacia into Malignancy

Malagon-Rangel,

Gabriel-Solis,

Zavala-Jonguitud

et al. 2023

Preprint

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Primäre Lebersarkome – Empfehlungen zur chirurgischen Therapie

et al. 2022

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Tumor‐induced Osteomalacia: A Case Report and Etiological Analysis with Literature Review

Zhang,

Li,

Zhang

et al. 2023

Orthopaedic Surgery

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BackgroundTumor‐induced osteomalacia (TIO) belongs to a rare disease of the paraneoplastic syndrome. Phosphate uric mesenchymal tumor (PMT) is the most common cause of TIO, while the possibility of other tumors cannot be excluded.Case presentationWe present a case of a 36‐year‐old female patient with systemic skeletal abnormalities. The woman complained of low back pain with mild motor dysfunction for 2 years. Laboratory examination showed abnormalities in markers of bone metabolism, parathyroid hormone (PTH), vitamin D and serum phosphorus. Pooled imaging examination indicated extension abnormalities in the skeletal system and a single lesion in the right femoral head. The lesion of the right femoral was imaging with somatostatin receptor‐positive, which was highly suggestive of a single neuroendocrine tumor. CT guided right femoral tumorectomy and bone grafting were performed when medical treatment failed. Postoperative pathological diagnosis was phosphate urinary mesenchymal tumor secreting fibroblast growth factor 23 (FGF23), which accorded with pre‐operative expectations. The postoperative symptoms were effectively relieved, and indicators returned to normal.ConclusionThe tumors causing TIO exhibited significant heterogeneity in terms of tissue origin, pathological characteristics and biological behavior, but the unique common characteristic is the secretion of FGF23. With significant progress in diagnosis and treatment, the clinical follow‐up of most TIO patients shows a good prognosis, but the prognosis of those with malignant tumors is relatively poor.

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Tumor‐induced osteomalacia in an adolescent with an undifferentiated embryonal sarcoma of the liver

Cited by 3 publications

References 11 publications

Transformation of a Long-Standing Phosphaturic Tumor Inducing Osteomalacia into Malignancy

Transformation of a Long-Standing Phosphaturic Tumor Inducing Osteomalacia into Malignancy

Primäre Lebersarkome – Empfehlungen zur chirurgischen Therapie

Tumor‐induced Osteomalacia: A Case Report and Etiological Analysis with Literature Review

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