Tumor immunity is related to ¹⁸F‐FDG uptake in thymic epithelial tumor

Abstract

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Prognostic Potential of Metabolic Activity on 18F-FDG Accumulation in Advanced NSCLC Receiving Combining Chemotherapy Plus PD-1 Blockade

“…Therefore, tumor metabolic volume measured by TLG may be a potentially related to PS, nutrition, and inflammation related to resistance to ICI therapy. Although several previous studies have disclosed a close relationship between glycolysis by SUV max and PD-L1 expression,12–14 MTV or TLG seemed to be unrelated to PD-L1 expression, supported by a previous approach 26. Furthermore, the relevance of 18 F-FDG uptake within the tumor microenvironment determined by tumor infiltrative lymphocytes (TILs) has been reported; however, SUV max by 18 F-FDG uptake indicates to be unrelated to the cell counting of CD4, CD8, and Foxp3 in TILs 13,14.…”

“…Although several previous studies have disclosed a close relationship between glycolysis by SUV max and PD-L1 expression, [12][13][14] MTV or TLG seemed to be unrelated to PD-L1 expression, supported by a previous approach. 26 Furthermore, the relevance of 18 F-FDG uptake within the tumor microenvironment determined by tumor infiltrative lymphocytes (TILs) has been reported; however, SUV max by 18 F-FDG uptake indicates to be unrelated to the cell counting of CD4, CD8, and Foxp3 in TILs. 13,14 Currently, the relationship between TILs and tumor metabolic volume by MTV or TLG remains unclear.…”

Determination of diagnostic and predictive parameters for vertical mandibular invasion in patients with lower gingival squamous cell carcinoma: A retrospective study

“…First, PD-L1 did not show significant results to be a predictive factor in univariate analysis. There have been reports of PD-L1 and metabolic imaging parameters demonstrating correlation [52][53][54][55] and no correlation. [56,57] PET also provides information on the metabolic state of the tumor microenvironment (TME), as the glucose analogue 18 F-FDG is transported by cancer cells and active immune cells, such as tumor-infiltrating lymphocytes (TIA) and tumor-associated macrophages (TAM).…”

Potential of VEGFR2 expression as a predictive marker of PD‑1 blockade in patients with advanced NSCLC

“…Immunohistochemical staining. Immunohistochemical staining was performed as previously described (17). VEGFR2 (1:100; Cell Signaling Technology, Inc.; cat #2472) was scored according to the stained tumor area (biopsy and surgical sample) as follows: 1, ≤10; 2, 11-24; 3, 25-49 and 4, ≥50% staining.…”

“…VEGFR2 (1:100; Cell Signaling Technology, Inc.; cat #2472) was scored according to the stained tumor area (biopsy and surgical sample) as follows: 1, ≤10; 2, 11–24; 3, 25–49 and 4, ≥50% staining. High and low expression were defined by scores of 1–3 and 4, respectively, for VEGFR2, as previously described ( 17 ). The sections were evaluated using a light microscope (×200 and ×400 magnification) in a blinded fashion by at least two authors.…”