Tumor-Immune Partitioning and Clustering (TIPC): an algorithm for identifying tumor-immune cell spatial interaction signatures within the tumor microenvironment
Abstract:Growing evidence supports the importance of quantifying tumor-immune cell interactions in the tumor microenvironment to enable precision cancer therapy. However, most existing methods rely solely upon immune cell density or nearest neighbor-type analyses and fail to fully characterize spatial heterogeneity. Herein, we describe a computational algorithm, termed Tumor-Immune Partitioning and Clustering (TIPC), that jointly measures immune cell partitioning between tumor epithelial and stromal areas and immune c… Show more
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