Tumor grade-related thallium-201 uptake in chondrosarcomas

Abstract

Tl-201 uptake was related to tumor grade in chondrosarcoma. If there is a possibility of chondrosarcoma, Tl-201 scintigraphy should be reported with caution.

Identification of novel biomarker candidates for immunohistochemical diagnosis to distinguish low‐grade chondrosarcoma from enchondroma

“…Histologically, distinction of between a low‐grade chondrosarcoma from a benign enchondroma relying solely on morphological features is difficult and even impossible in many cases for skilled pathologists because of their similar cytology, cellularity, and cartilaginous matrix . Therefore, correlative interpretation of histopathological features, X‐ray imaging, computerized tomography, magnetic resonance imaging, clinical examination, and epidemiological information is currently used for making this distinction . Most often, however, a histopathological stain of specimen must be obtained in order to guarantee an accurate confirmation .…”

Diagnostic accuracy of functional imaging modalities for chondrosarcoma: A systematic review and meta-analysis

“…In the participant selection domain, six studies were considered to be at low risk of bias [5,10,13,[25], [26], [27]. There was insufficient reporting to determine whether the participants were randomly or consecutively enrolled in seven studies [28], [29], [30], [31], [32], [33], [34]. We had excluded studies with a case-control design as our focus was on the effectiveness of selected imaging modalities in differentiating between chondrosarcoma and benign chondroid tumours.…”

“…Four studies [10,15,25,35] set sensitivity and specificity maximising threshold values for diagnosis with the knowledge of reference test results. In six studies [13,27,28,31,32,36], the index test was performed before the histological assessment hence we inferred that they did not have the knowledge of the reference standard. Eight studies relied on visual assessment of uptake [5,13,28,[30], [31], [32],36].…”

“…Nevertheless, it is the accepted general standard in nuclear medicine. In the reference standard domain, it was unclear whether assessors of the reference standard were blinded to the index test results in 11 studies [5,10,13,15,25,28,[30], [31], [32],36]. We considered a follow-up for longer than 12 months for benign tumours was sufficient to correctly identify them.…”

“…Four studies addressed the value of FDG-PET in the diagnostic work-up for chondroid tumours [15,25,26,30]. Three studies assessed Tc-99 m MDP [5,27,36], four studies focused on Thallium-201 scintigraphy [10,13,28,31], and three studies reported on Tc-99 m DMSA (V) [13,32,37]. All studies reported data at patient level except for two studies that reported on all single lesions [26,32].…”