Tumor Focality Does Not Predict Biochemical Recurrence After Radical Prostatectomy in Men With Clinically Localized Prostate Cancer

Masterson, Timothy A.; Liu, Cheng; Mehan, Rahul; Koch, Michaël

doi:10.1016/j.juro.2011.03.106

Cited by 22 publications

(16 citation statements)

References 17 publications

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“…A previous report indicated that tumor focality can significantly influence the BCR-free survival rate [31]. However, more-recent reports indicated that tumor focality did not predict the risk of BCR after an RP in men with clinically-localized PCa, even if the tumor involved both lobes of the prostate [32], suggesting that tumor focality might not be a suitable predictive marker for BCR in patients with organ-confined PCa. Our study observed that p-Akt expression level should be a better predictive marker of BCR in this PCa population.…”

Section: Discussionmentioning

confidence: 99%

Akt Activation Correlates with Snail Expression and Potentially Determines the Recurrence of Prostate Cancer in Patients at Stage T2 after a Radical Prostatectomy

Chen

Hua

Lee

et al. 2016

IJMS

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Our previous work demonstrated the epithelial-mesenchymal transition factor, Snail, is a potential marker for predicting the recurrence of localized prostate cancer (PCa). Akt activation is important for Snail stabilization and transcription in PCa. The purpose of this study was to retrospectively investigate the relationship between the phosphorylated level of Akt (p-Akt) in radical prostatectomy (RP) specimens and cancer biochemical recurrence (BCR). Using a tissue microarray and immunohistochemistry, the expression of p-Akt was measured in benign and neoplastic tissues from RP specimens in 53 patients whose cancer was pathologically defined as T2 without positive margins. Herein, we observed that the p-Akt level was higher in PCa than in benign tissues and was significantly associated with the Snail level. A high p-Akt image score (≥8) was significantly correlated with a higher histological Gleason sum, Snail image score, and preoperative prostate-specific antigen (PSA) value. Moreover, the high p-Akt image score and Gleason score sum (≥7) showed similar discriminatory abilities for BCR according to a receiver-operator characteristic curve analysis and were correlated with worse recurrence-free survival according to a log-rank test (p < 0.05). To further determine whether a high p-Akt image score could predict the risk of BCR, a Cox proportional hazard model showed that only a high p-Akt image score (hazard ratio (HR): 3.12, p = 0.05) and a high Gleason score sum (≥7) (HR: 1.18, p = 0.05) but not a high preoperative PSA value (HR: 0.62, p = 0.57) were significantly associated with a higher risk of developing BCR. Our data indicate that, for localized PCa patients after an RP, p-Akt can serve as a potential prognostic marker that improves predictions of BCR-free survival.

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Section: Discussionmentioning

confidence: 99%

Akt Activation Correlates with Snail Expression and Potentially Determines the Recurrence of Prostate Cancer in Patients at Stage T2 after a Radical Prostatectomy

Chen

Hua

Lee

et al. 2016

IJMS

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“…Multifocality remains the most common pattern of disease distribution, with solitary lesions occurring in 13% of patients [14][15][16]. The random sampling that is routinely implemented samples less than 1/1000th of the prostate volume.…”

Section: Editorialmentioning

confidence: 99%

Early detection of prostate cancer: can we have our cake and eat it too?

Masterson

Cary

Liu

2016

Expert Review of Anticancer Therapy

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“…Review of biopsy findings suggests that the expected number of cases with unifocal disease may be in the range of 13%–35% 53,54. Of those with low-risk unifocal disease, only 1% displayed extracapsular extension 55.…”

Section: Selection Of Appropriate Patientsmentioning

confidence: 99%

Focal low-dose rate brachytherapy for the treatment of prostate cancer

Tong

Cohen²,

Yamada

2013

CMAR

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Whole-gland low-dose rate (LDR) brachytherapy has been a well-established modality of treating low-risk prostate cancer. Treatment in a focal manner has the advantages of reduced toxicity to surrounding organs. Focal treatment using LDR brachytherapy has been relatively unexplored, but it may offer advantages over other modalities that have established experiences with a focal approach. This is particularly true as prostate cancer is being detected at an earlier and more localized stage with the advent of better detection methods and newer imaging modalities.

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Tumor Focality Does Not Predict Biochemical Recurrence After Radical Prostatectomy in Men With Clinically Localized Prostate Cancer

Abstract: In this study tumor focality failed to predict patients likely to experience biochemical failure. Tumor characteristics were similar regardless of focality. However, unifocal tumors had smaller volume and were more commonly seen as clinically insignificant compared to multifocal tumors.

Cited by 22 publications

References 17 publications

Akt Activation Correlates with Snail Expression and Potentially Determines the Recurrence of Prostate Cancer in Patients at Stage T2 after a Radical Prostatectomy

Akt Activation Correlates with Snail Expression and Potentially Determines the Recurrence of Prostate Cancer in Patients at Stage T2 after a Radical Prostatectomy

Early detection of prostate cancer: can we have our cake and eat it too?

Focal low-dose rate brachytherapy for the treatment of prostate cancer

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