Tumor Enhancement Effect of Overexpressed Manganese-superoxide Dismutase in Manganese-enhanced MR Imaging

Hasegawa, Sumitaka; Saito, Shigeyoshi; Koshikawa-Yano, Michiko; Furukawa, Takako; Aoki, Ichio; Saga, Tsuneo

doi:10.2463/mrms.10.155

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Because of the more severe functional impairment of mitochondria in more malignant tumour cells, the Mn 2+ entering the mitochondria might be less than that in less aggressive tumour cells, resulting in more Mn 2+ accumulating freely in cytosol, thus causing greater T1 shortening. Finally, the contribution from Mn 2+ in the extracellular compartment should probably also not be overlooked [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Manganese-enhanced MRI for the detection of metastatic potential in colorectal cancer

Wen

Shi

et al. 2017

Eur Radiol Exp

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BackgroundTo study manganese superoxide dismutase (MnSOD) expression, manganese-enhanced magnetic resonance imaging (MEMRI) appearance and its relation to metastatic potential in colorectal cancer (CRC).MethodsCRC cells SW620, HCT116, LoVo, SW480, DLD-1, HCT15, Caco-2 and their normal counterpart CCD841 CoN were chosen, based on differential aggressiveness, to undergo Western blot analysis for assessment of MnSOD expression, reported as proportion of readings to internal reference (glyceraldehyde-3-phosphate-dehydrogenase). Based on the results of the invasion assay, HCT15, DLD-1, LoVo and SW620 cells and corresponding xenografts underwent MEMRI. The differences of average T1-value shortening were compared.ResultsMnSOD expression in SW620, HCT116, LoVo, SW480, DLD-1, HCT15, Caco-2 and CCD841 CoN cells (0.255 ± 0.018 (mean ± standard deviation), 0.289 ± 0.028, 0.438 ± 0.028, 0.337 ± 0.025, 0.777 ± 0.031, 1.045 ± 0.038, 0.163 ± 0.035 and 0.185 ± 0.038, respectively) was not correlated with Invasion Index (22.6 ± 0.7, 17.0 ± 0.6, 20.9 ± 0.6, 9.7 ± 0.4, 7.5 ± 0.3, 8.3 ± 0.2, 12.6 ± 0.5 and 0) (r = − 0.204, p = 0.627). In highly aggressive cells (SW620, LoVo), T1 shortening (289.33 ± 0.57, 268.45 ± 6.87 ms, respectively) was greater than that in lower counterparts (148.68 ± 3.99 ms in DLD-1, 128.60 ± 1.96 in HCT15) (p < 0.001). Both 5- and 10-mm group SW620 and/or LoVo tumours showed greater T1 shortening (≥600 ms) than DLD-1 and HCT15 (≤350 ms) (p < 0.001, p = 0.005, p = 0.010).ConclusionsMEMRI has the potential to noninvasively distinguish different metastatic potential CRCs. However, the MnSOD expression is not correlated to malignant potential in CRC cells.

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Section: Discussionmentioning

confidence: 99%

Manganese-enhanced MRI for the detection of metastatic potential in colorectal cancer

Wen

Shi

et al. 2017

Eur Radiol Exp

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“…Manganese-enhanced magnetic resonance imaging (MEMRI), which is currently used to assess brain activity and to track neuronal connections, may be useful for detecting ovarian cancer cells with Mn-SOD overexpression, where signal enhancement can be observed [ 166 ]. Han et al [ 167 ] in their work described a dual-modal fluorescence/MR nanoprobe with carbon nanoparticles combined with manganese and nitrogen (Mn-N-CNSs) and conjugated to an anti-HE4 monoclonal antibody (Mn-N-CNSs @ anti-HE4) that can be used in the diagnosis of ovarian cancer cells.…”

Section: Ovarian Cancermentioning

confidence: 99%

The Role of Selenium and Manganese in the Formation, Diagnosis and Treatment of Cervical, Endometrial and Ovarian Cancer

Golara

Kozłowski

Guzik

et al. 2023

IJMS

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Selenium (Se) and manganese (Mn) are essential micronutrients that are important elements of cell metabolism. They are involved in the composition of enzyme systems and regulate enzyme activity. Disturbances in the homeostasis of these micronutrients affect the development of many diseases and carcinogenesis, which can be linked to increased levels of oxidative stress and impaired antioxidant properties of many enzymes. Selenium has a very important function in maintaining immune-endocrine, metabolic and cellular homeostasis. Manganese, on the other hand, is important in development, digestion, reproduction, antioxidant defense, energy production, immune response and regulation of neuronal activity. We review the role of selenium and manganese and their effects on tumor growth, metastasis potential and remodeling of the microenvironment. We also describe their role as potential biomarkers in the diagnosis and the potential for the use of Se- and Mn-containing compounds in composition for the treatment of cancer of the reproductive organs.

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“…Presently, there are three major uses of MEMRI in the brain: for enhancement of brain cytoarchitecture in anatomical studies (Natt et al, 2002; Watanabe et al, 2002, 2004; Aoki et al, 2004b), for mapping neuronal activity (Lin and Koretsky, 1997; Aoki et al, 2002, 2004a; Hsu et al, 2007; Yu et al, 2008) and for in vivo tracing of neuronal connections (Pautler et al, 1998, 2003; Van der Linden et al, 2002). The use of MEMRI for anatomy and function extends to other tissues as well, such as heart (Hu et al, 2001), pancreas (Gimi et al, 2006) and tumors (Banerjee et al, 2007; Hasegawa et al, 2011). …”

Section: Introductionmentioning

confidence: 99%

Transcranial manganese delivery for neuronal tract tracing using MEMRI

et al. 2017

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There has been a growing interest in the use of manganese-enhanced MRI (MEMRI) for neuronal tract tracing in mammals, especially in rodents. For this MEMRI application, manganese solutions are usually directly injected into specific brain regions. Recently it was reported that manganese ions can diffuse through intact rat skull. Here the local manganese concentrations in the brain tissue after transcranial manganese application were quantified and the effectiveness of tracing from the area under the skull where delivery occurred was determined. It was established that transcranially applied manganese yields brain tissue enhancement dependent on the location of application on the skull and that manganese that enters the brain transcranially can trace to deeper brain areas.

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Tumor Enhancement Effect of Overexpressed Manganese-superoxide Dismutase in Manganese-enhanced MR Imaging

Cited by 4 publications

References 6 publications

Manganese-enhanced MRI for the detection of metastatic potential in colorectal cancer

Manganese-enhanced MRI for the detection of metastatic potential in colorectal cancer

The Role of Selenium and Manganese in the Formation, Diagnosis and Treatment of Cervical, Endometrial and Ovarian Cancer

Transcranial manganese delivery for neuronal tract tracing using MEMRI

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