Tumor Diameter and Volume Assessed by Magnetic Resonance Imaging in the Prediction of Outcome for Invasive Cervical Cancer

Wagenaar, Hendrik; Trimbos, J. Baptist; Postema, S.; Anastasopoulou, A.; Geest, R.J. van der; Reiber, J. H. C.; Kenter, Gemma G.; Peters, Alexander; Pattynama, Peter M. T.

doi:10.1006/gyno.2001.6267

Cited by 94 publications

(63 citation statements)

References 19 publications

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“…This was done three times in each patient by a single observer (NdS) and a o1% variation in volume obtained between the readings. Previous correlation of such measurements with volumes measured on pathology specimens has shown excellent agreement (Wagenaar et al, 2000).…”

Section: Discussionmentioning

confidence: 86%

Use of neoadjuvant chemotherapy prior to radical hysterectomy in cervical cancer: monitoring tumour shrinkage and molecular profile on magnetic resonance and assessment of 3-year outcome

et al. 2004

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The objective of this study is to assess tumour response to neoadjuvant chemotherapy prior to radical hysterectomy in cervical cancer using magnetic resonance (MR) to monitor tumour volume and changes in molecular profile and to compare the survival to that of a control group. Eligibility included Stage Ib -IIb previously untreated cervical tumours 410 cm 3 . Neoadjuvant chemotherapy in 22 patients (methotrexate 300 mg m À2 (with folinic acid rescue), bleomycin 30 mg m À2 , cisplatin 60 mg m À2 ) was repeated twice weekly for three courses and followed by radical hysterectomy. Post-operative radiotherapy was given in 14 cases. A total of 23 patients treated either with radical surgery or chemoradiotherapy over the same time period comprised the nonrandomised control group. MR scans before and after neoadjuvant chemotherapy and in the control group documented tumour volume on imaging and metabolites on in vivo spectroscopy. Changes were compared using a paired t-test. Survival was calculated using the Kaplan -Meier method. There were no significant differences between the neoadjuvant chemotherapy and control groups in age (mean, s.d. 43.3710, 44.778.5 years, respectively, P ¼ 0.63) or tumour volume (medians, quartiles 35.8, 17.8, 57.7 cm 3 vs 23.0, 15.0, 37.0 cm 3 , respectively, P ¼ 0.068). The reduction in tumour volume post-chemotherapy (median, quartiles 7.5, 3.0, 19.0 cm 3 ) was significant (P ¼ 0.002). The reduction in -CH 2 triglyceride approached significance (P ¼ 0.05), but other metabolites were unchanged. The 3-year survival in the chemotherapy group (49.1%) was not significantly different from the control group (46%, P ¼ 0.94). There is a significant reduction in tumour volume and -CH 2 triglyceride levels after neoadjuvant chemotherapy, but there is no survival advantage.

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Section: Discussionmentioning

confidence: 86%

Use of neoadjuvant chemotherapy prior to radical hysterectomy in cervical cancer: monitoring tumour shrinkage and molecular profile on magnetic resonance and assessment of 3-year outcome

et al. 2004

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“…The preoperative assessment estimated the tumor volume, the degree of stromal invasion, the distance from the internal cervical os, the extracervical extension, and the possibility of lymph node invasion. Protocols validated by several studies were used to interpret the data obtained by vaginal ultrasonography and MRI [19,20].…”

Section: Discussionmentioning

confidence: 99%

Radical Vaginal Trachelectomy with Laparoscopic Pelvic Lymphadenectomy for Fertility Preservation in Young Women with Early-Stage Cervical Cancer

Brătilă

Coroleucă³

2015

Indian J Surg

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The primary objective of this study was to describe our experience with the conservative treatment of early-stage cervical cancer (stages IA1, IA2, and IB1) with radical vaginal trachelectomy (RVT) and laparoscopic pelvic lymphadenectomy. This retrospective observational case series included 36 patients with early cervical cancer. Radical trachelectomy and laparoscopic pelvic lymphadenectomy were performed as described by D. Dargent in 32 of these cases. Oncologic, reproductive, and obstetric outcomes were observed subsequently over a median period of 42 (24-96) weeks. A total of 32 RVTs were preformed with a mean operating time of 117±22.8 (77-167) minutes and an average blood loss of 486 mL (150-800 mL). All obtained resection margins were negative for cancer. Lymphovascular space invasion was noted in 11 (30.55 %) of the cases. No recurrences occurred during the study period. Seven (17.8 %) patients were able to become pregnant postoperatively, five of whom delivered healthy infants near term. Radical vaginal trachelectomy with laparoscopic pelvic lymphadenectomy appears to be a safe therapeutic option for fertility preservation in young women with early cervical cancer.

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“…Accurate staging in cervical carcinoma is essential in therapeutic decision-making, determining prognosis, and comparing the results of different treatment modalities in these inoperable patients. Recently, primary tumor size has been well established in a large number of studies as an important independent predictor to survival in inoperable cervical cancer [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Therefore, the appropriate method and its accuracy for tumor size measurement to provide p-value comparing <20 mL and 20-39 mL groups.…”

Section: Discussionmentioning

confidence: 99%

“…The size and volume of the primary tumor are well-established prognostic factors and predictors of the radiation therapy outcome for cervical cancer patients [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. With the advent of magnetic resonance imaging (MRI), it has become possible to estimate the size of the primary tumor more accurately than was prior possible by clinical palpation or computer tomography (CT) in inoperable patient [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Method of Tumor Volume Evaluation using Magnetic Resonance Imaging for Outcome Prediction in Cervical Cancer Treated with Concurrent Chemotherapy and Radiotherapy

Kim

2008

International Journal of Radiation Oncology*Biology*Physics

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Tumor Diameter and Volume Assessed by Magnetic Resonance Imaging in the Prediction of Outcome for Invasive Cervical Cancer

Cited by 94 publications

References 19 publications

Use of neoadjuvant chemotherapy prior to radical hysterectomy in cervical cancer: monitoring tumour shrinkage and molecular profile on magnetic resonance and assessment of 3-year outcome

Use of neoadjuvant chemotherapy prior to radical hysterectomy in cervical cancer: monitoring tumour shrinkage and molecular profile on magnetic resonance and assessment of 3-year outcome

Radical Vaginal Trachelectomy with Laparoscopic Pelvic Lymphadenectomy for Fertility Preservation in Young Women with Early-Stage Cervical Cancer

Method of Tumor Volume Evaluation using Magnetic Resonance Imaging for Outcome Prediction in Cervical Cancer Treated with Concurrent Chemotherapy and Radiotherapy

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