Tumor‐derived exosomes enhance invasion and metastasis of salivary adenoid cystic carcinoma cells

Hou, Jin; Wang, Fangyuan; Liu, Xiaohao; Song, Mengyang; Yin, Xuemin

doi:10.1111/jop.12654

Cited by 25 publications

(20 citation statements)

References 29 publications

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“…This indicates that interventions targeting exosome biogenesis and release may be of therapeutic value against PNI ( 92 ). Of particular note, in our previous study, we found that the exosomes derived from the adenoid cystic carcinoma cell line (SACC-83) could be uptaken by human umbilical vein endothelial cells (HUVECs), and destroyed the vascular endothelial barrier ( 93 ). Considering that primary tumor-derived EVs can destroy epithelial cell tight junction assembly to induce EMT, and trigger vascular permeability to allow cancer cell dissemination, and “educate” pre-metastatic sites in distant organs, we propose that EVs may also contribute to the disruption of the perineurium barrier and education of the perineural sites into a tumor-promoting microenvironment.…”

Section: Possible Mechanism Of Pni and Conclusionmentioning

confidence: 98%

Perineural Invasion in Adenoid Cystic Carcinoma of the Salivary Glands: Where We Are and Where We Need to Go

et al. 2020

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Adenoid cystic carcinoma of the salivary gland (SACC) is a rare malignant tumors of the head and neck region, but it is one of the most common malignant tumors that are prone to perineural invasion (PNI) of the head and neck. The prognosis of patients with SACC is strongly associated with the presence of perineural spread (PNS). Although many contributing factors have been reported, the mechanisms underlying the preferential destruction of the blood-nerve barrier (BNB) by tumors and the infiltration of the tumor microenvironment by nerve fibers in SACC, have received little research attention. This review summarizes the current knowledge concerning the characteristics of SACC in relation to the PNI, and then highlights the interplay between components of the tumor microenvironment and perineural niche, as well as their contributions to the PNI. Finally, we provide new insights into the possible mechanisms underlying the pathogenesis of PNI, with particular emphasis on the role of extracellular vesicles that may serve as an attractive entry point in future studies.

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Section: Possible Mechanism Of Pni and Conclusionmentioning

confidence: 98%

Perineural Invasion in Adenoid Cystic Carcinoma of the Salivary Glands: Where We Are and Where We Need to Go

et al. 2020

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“…Exosomes containing EGFR from OSCC cells were capable of transforming normal epithelial cells into a mesenchymal phenotype in a paracrine fashion [17]. Hou et al found that exosomes from salivary adenoid cystic carcinoma cell line SACC-83 enhanced the migration and invasion ability of the parental SACC-83 by targeting cell junction-associated proteins, including claudin-1, ZO-1, and β-catenin [16,39].…”

Section: Proteins In Oscc Cell-derived Exosomesmentioning

confidence: 99%

“…Recent studies have revealed the multifaceted roles of exosomes in oral diseases. Oral cancer-derived exosomes exacerbated the malignancy of cancers [16][17][18][19]. Li et al proved the hypoxic oral squamous cell carcinoma (OSCC) cells secreted miR-21-rich exosomes in a HIFdependent manner [20].…”

Section: Introductionmentioning

confidence: 99%

Emerging functions and clinical applications of exosomes in human oral diseases

2020

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Exosomes are cell-derived membranous vesicles of endosomal origin secreted by all type of cells and present in various body fluids. Exosomes are enriched in peptides, lipids, and nucleic acids, emerging as vital modulators in intercellular communication. Exosomes are increasingly being evaluated as biomarkers for diagnosis and prognosis of diseases, because the constituents of exosomes could be reprogrammed depending on the states of diseases. These features also make exosomes a research hotspot in oral diseases in recent years. In this review, we outlined the characteristics of exosomes, focused on the differential expressions and altered biological functions of exosomes in oral diseases, including oral squamous cell carcinoma, oral leukoplakia, periodontitis, primary Sjögren's syndrome, oral lichen planus, as well as hand foot and mouth disease. Besides, accumulated evidence documents that it is implementable to consider the natural nanostructured exosomes as a new strategy for disease treatment. Herein, we highlighted the therapeutic potential of exosomes in oral tissue regeneration, oncotherapy, wound healing, and their superiority as therapeutic drug delivery vehicles.

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“…By artificially mimicking the OSCC TME (arranging tumor cells in a three-dimensional myoma or collagen gel model), it was found that tumor-derived exosomes play an important role in regulating tumor epithelial morphology and function [69]. Exosomes could promote the formation of tumor epithelial islands and of the expression of interstitial cell characteristics, such as upregulating N-cadherin, downregulating E-cadherin and GLI-1, and eventually promoting the epithelial-mesenchymal transition (EMT) [70, 71]. Shinya Sento et al demonstrated that OSCC-derived exosomes can self-uptake or become absorbed by surrounding tumor cells and then accelerate cell proliferation and invasion by activating AKT, MAPK/ERK, and JNK signaling pathways [72].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, nasopharyngeal carcinoma (NPC) cell-derived exosomal miRNA-23a directly target the TSGA10 region to promote endothelial cell proliferation, migration and tube formation to regulate tumor growth [97]. Recent studies have shown that epiegulin-, MMP-13-, ICAM-1- or TSP-1-enriched exosomes could strengthen the release of vascular endothelial growth factors (VEGF-A, FGF-2, IL-8) and then downregulate junction-related proteins (claudins and ZO-1) that promote tumor angiogenesis and vascular permeability, becoming a potential passway system for distant metastasis of tumor cells [70, 71, 73, 98].…”

Section: Introductionmentioning

confidence: 99%

The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers

Xie

Tang

et al. 2019

Mol Cancer

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The proliferation and metastasis ability of tumors are mediate by the "mutual dialogue" between cells in the tumor microenvironment (TME). Extracellular vesicles (EVs), mainly exosomes and microvesicles, play an important role in achieving intercellular substance transport and information transfer in the TME. Initially considered "garbage dumpsters" and later referred to as "signal boxes", EVs carry "cargo" (proteins, lipids, or nucleic acids) that can redirect the function of a recipient cell. Currently, the molecular mechanisms and clinical applications of EVs in head and neck cancers (HNCs) are still at an early stage and need to be further investigate. In this review, we provide insight into the TME of HNCs, classifying and summarizing EVs derived from different cell types and illuminating their complex signaling networks involved in mediating tumor proliferation, invasion and metastasis, vascular angiogenesis and cancer drug resistance. In addition, we highlight the application of EVs in HNCs, underlining the special pathological and physiological environment of HNCs. The application of tumor heterogeneous EVs in saliva and circulating blood diagnostics will provide a new perspective for the early screening, real-time monitoring and prognostic risk assessment of HNCs. Given the concept of precise and individual therapy, nanostructured EVs are equipped with superior characteristics of biocompatibility, low immunogenicity, loadability and modification ability, making these molecules one of the new strategies for HNCs treatment.

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Tumor‐derived exosomes enhance invasion and metastasis of salivary adenoid cystic carcinoma cells

Abstract: The results suggested that SACC cell-derived exosomes were loaded with individual components that could enhance invasiveness and induce microenvironment changes, thus promoting SACC aggression.

Cited by 25 publications

References 29 publications

Perineural Invasion in Adenoid Cystic Carcinoma of the Salivary Glands: Where We Are and Where We Need to Go

Perineural Invasion in Adenoid Cystic Carcinoma of the Salivary Glands: Where We Are and Where We Need to Go

Emerging functions and clinical applications of exosomes in human oral diseases

The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers

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