Tumor-derived covalent organic framework nanozymes for targeted chemo-photothermal combination therapy

Zhou, Shengnan; Tian, Tian; Meng, Tao; Wu, Jin; Hu, Danyou; Liao, Qiaobo; Zhuang, Jie; Wang, Hua; Gao, Shan

doi:10.1016/j.isci.2023.107348

Cited by 8 publications

(7 citation statements)

References 57 publications

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“…Then, COF nanozymes with simulated nitroreductase activity and peroxide-mimetic enzyme activity were pre pared by in situ loading AuNPs in COF through hydrogen bonding or π-π bonding. Zhou et al [30] also used the condensation reaction of aldehydes and amines to prepare imine linked tetragonal COF nanozymes (Tph-BDP) through the combination of [C2 + C2] and the solvothermal synthesis method. Then, AuNPs were loaded in situ through strong Au SH interaction to prepare COF nanozymes for the treatment of liver cancer (Figure 3C) From the above research results, it can be concluded that the design of COF nanozymes is traceable.…”

Section: Design Principle Of Cof Nanozymesmentioning

confidence: 99%

“…Among them, COF surface-loaded metal nanoparticles are the most common COF nanozymes. For example, metal-loaded COF nanozymes can be prepared by loading gold nanoparticles or silver nanoparticles on the COF surface [29,30]. Among the many COF carriers, boron-linked COFs have high crystallinity and low density, but they are sensitive to water, resulting in poor stability, which may limit the application of boron-linked COFs in some aspects [43].…”

Section: Metal-loaded Cof Nanozymesmentioning

confidence: 99%

“…In addition, the iminelinked COF skeleton is rich in nitrogen and can coordinate with metal ions, providing feasibility for the preparation of metal-loaded COF nanozymes [50][51][52]. Imine-linked COFs can be combined with metal materials through Au-SH bonds [30], coordination of unsaturated amino groups [53], and other forces to prepare COF nanozymes. An imine-…”

Section: Metal-loaded Cof Nanozymesmentioning

confidence: 99%

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Research Progress on the Application of Covalent Organic Framework Nanozymes in Analytical Chemistry

Yao,

Xia,

2024

Biosensors

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Covalent organic frameworks (COFs) are porous crystals that have high designability and great potential in designing, encapsulating, and immobilizing nanozymes. COF nanozymes have also attracted extensive attention in analyte sensing and detection because of their abundant active sites, high enzyme-carrying capacity, and significantly improved stability. In this paper, we classify COF nanozymes into three types and review their characteristics and advantages. Then, the synthesis methods of these COF nanozymes are introduced, and their performances are compared in a list. Finally, the applications of COF nanozymes in environmental analysis, food analysis, medicine analysis, disease diagnosis, and treatment are reviewed. Furthermore, we also discuss the application prospects of COF nanozymes and the challenges they face.

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Section: Design Principle Of Cof Nanozymesmentioning

confidence: 99%

Section: Metal-loaded Cof Nanozymesmentioning

confidence: 99%

Section: Metal-loaded Cof Nanozymesmentioning

confidence: 99%

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Research Progress on the Application of Covalent Organic Framework Nanozymes in Analytical Chemistry

Yao,

Xia,

2024

Biosensors

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“…Coating COF nanoparticles with tumor cell membranes also limits opsonin adsorption, thereby decreasing phagocytic clearance and prolonging blood circulation time. [143] Nanomotors, which are also known as "colloidal robotics", are nanoparticles that convert external energy into kinetic energy. These nanoparticles can semiactively approach tumor sites, thereby facilitating the aggregation of nanomedicines at tumor sites.…”

Section: Targeted Delivery and Therapymentioning

confidence: 99%

Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy

Zhou,

Guan,

Dong

2023

Angew Chem Int Ed

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Nanomedicines are extensively used in cancer therapy. Covalent organic frameworks (COFs) are crystalline organic porous materials with several benefits for cancer therapy, including porosity, design flexibility, functionalizability, and biocompatibility. This review examines the use of COFs in cancer therapy from the perspective of reticular chemistry and function‐oriented materials design. First, the modification sites and functionalization methods of COFs are discussed, followed by their potential as multifunctional nanoplatforms for tumor targeting, imaging, and therapy by integrating functional components. Finally, some challenges in the clinical translation of COFs are presented with the hope of promoting the development of COF‐based anticancer nanomedicines and bringing COFs closer to clinical trials.

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“…Due to advantages, such as easy synthesis and high catalytic activity, conferred by nanozymes, they have come to be considered as a next generation of enzyme mimics. , Nanozymes have very recently been successfully applied to ferroptosis-based tumor therapy. − Among the various nanozymes reported in the literature, covalent organic framework (COF) nanozymes have already exhibited excellent potential in sensing, − antibiosis, − and antitumor treatment − owing to their high crystallinity, intrinsic porosity, structural regularity, design flexibility, customizable pore environment, versatility, and exceptional stability. , Although they have not yet been used for radiotherapy sensitization, COF-based nanozymes should, in principle, be synthesizable via function-oriented material design. If synthesized, the multifunctional COF nanozymes so obtained would not only increase X-ray energy deposition (owing to the introduction of high- Z elements) but also exert multiple nanozyme effects, inducing sustained lipid peroxidation and reductant depletion, thereby disrupting cellular redox homeostasis and enhancing radiosensitivity …”

mentioning

confidence: 99%

A Multifunctional Covalent Organic Framework Nanozyme for Promoting Ferroptotic Radiotherapy against Esophageal Cancer

Zhou,

Guan,

Zhou

et al. 2023

ACS Nano

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Radiotherapy is inevitably accompanied by some degree of radiation resistance, which leads to local recurrence and even therapeutic failure. To overcome this limitation, herein, we report the room-temperature synthesis of an iodineand ferrocene-loaded covalent organic framework (COF) nanozyme, termed TADI-COF-Fc, for the enhancement of radiotherapeutic efficacy in the treatment of radioresistant esophageal cancer. The iodine atoms on the COF framework not only exerted a direct effect on radiotherapy, increasing its efficacy by increasing X-ray absorption, but also promoted the radiolysis of water, which increased the production of reactive oxygen species (ROS). In addition, the ferrocene surface decoration disrupted redox homeostasis by increasing the levels of hydroxyl and lipid peroxide radicals and depleting intracellular antioxidants. Both in vitro and in vivo experiments substantiated the excellent radiotherapeutic response of TADI-COF-Fc. This study demonstrates the potential of COF-based multinanozymes as radiosensitizers and suggests a possible treatment integration strategy for combination oncotherapy.

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Tumor-derived covalent organic framework nanozymes for targeted chemo-photothermal combination therapy

Cited by 8 publications

References 57 publications

Research Progress on the Application of Covalent Organic Framework Nanozymes in Analytical Chemistry

Research Progress on the Application of Covalent Organic Framework Nanozymes in Analytical Chemistry

Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy

A Multifunctional Covalent Organic Framework Nanozyme for Promoting Ferroptotic Radiotherapy against Esophageal Cancer

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