Tumor deposits in salivary gland tumors

Abstract

Tumor deposits (TDs), identified in different types of carcinomas are associated with poor prognosis. Salivary gland tumors were evaluated for the first time for TDs in this series. Pathological and clinical features of 25 salivary gland carcinomas primarily treated surgically including neck dissection were determined and all cases were evaluated for TDs in dissection specimens. Seven patients (28%) had TDs. There was no difference for TDs when histological type, tumor grade, tumor localization, pT, pN stage, surgical margin, lymphovascular, perineural invasion, local recurrence, distant metastatic disease and overall survival were considered. Disease-free survival rates at 12 and 24 months were 52.5%, 28.6% and 73.3%, 57.1%, for cases with and without TDs (P = 0.463). Overall survival rates at 12 and 24 months for these groups were 85.7% and 57.1 versus 86.7% and 66.7% respectively (P = 0.916). Mean estimated recurrence-free survival time for all cases, TD negative and TD positive cases were: 171.86, 182.72 and 82.42 months, respectively. Mean estimated overall survival time for these groups were 175.80, 186.489 and 89.70 months, respectively. TDs were described in salivary gland tumors for the first time in this series and seem to be associated with poor prognosis requiring further evaluation in larger series.

Tumor deposits in thyroid carcinomas

“…In our thyroid carcinoma case series who had cervical lymph node sampling and/ or dissection, TDs were detected in 27.8%. The incidence of TDs varies between 16.6% and 43.9% in colorectal carcinomas, [10,11] 17.8% and 24.0% in gastric carcinomas, [4,22] 17.1% in head and neck carcinomas, [6] 28.0% in salivary gland tumors, [8] 24.6% in esophageal carcinomas, [23] and 29.0% in breast carcinomas. [9] In our case series, 44 patients with TPC (25.0%) and 10 patients with TMC (55.6%) had TDs.…”

“…[1] Although first reported in 1935, the interest in TDs arose particularly in the last 3 decades, with increasing literature about its association with poor prognosis in different cancer groups. [2][3][4][5][6][7][8][9] Most studies regarding the prognostic significance of TDs are in colorectal carcinomas, [2,[10][11][12][13] accordingly, in the recent American Joint Committee on Cancer classification system their presence change the nodal status to pN1c, if no metastatic regional lymph nodes are detected on pathological examination. [14] Thyroid carcinomas, particularly differentiated thyroid carcinomas arising from the follicular epithelial cells, are the most common endocrine malignancies.…”

Angiotropism in recurrent cutaneous squamous cell carcinoma: Implications for regional tumor recurrence and extravascular migratory spread

“…EVMM can involve a wide range of blood vessels sizes, ranging from capillaries to large‐caliber blood vessels . While the majority of the blood vessels with EVMM in melanoma tend to be capillaries, involvement of medium‐ to large‐caliber vessels appears to be common in carcinoma, particularly in those arising in head and neck, in addition to certain abdominal tumors, including pancreatic adenocarcinoma …”

“…11 EVMM can involve a wide range of blood vessels sizes, ranging from capillaries to large-caliber blood vessels. 2,[29][30][31] While the majority of the blood vessels with EVMM in melanoma tend to be capillaries, involvement of medium-to large-caliber vessels appears to be common in carcinoma, 7 particularly in those arising in head and neck, 29,30,32 in addition to certain abdominal tumors, including pancreatic adenocarcinoma. 7 Tracking of neoplastic cells along several anatomic structures including nerve fibers, fascial planes, skeletal muscle, and blood vessels is a well-documented phenomenon in SCC, particularly in those that arise in the head and neck region.…”