Tumor deposits in gastric carcinomas

Erşen, Ayça; Ünlü, Mehtat; Akman, Tülay; Sağol, Özgül; Öztop, İlhan; Atıla, Koray; Bora, Seymen; Ellıdokuz, Hülya; Sarıoğlu, Sülen

doi:10.1016/j.prp.2014.03.006

Cited by 28 publications

(27 citation statements)

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“…The patients in ENMP group had remarkably more advanced tumors and suffered significantly worse prognosis than those in ENMN group in all patients, which was similar to many previous studies [2, 5–7, 10]. Another previous study reported that ENM was correlated with intestinal type [9]. When stratified by TNM stage, the similar results were found in TNM I-II, III, IIIB and IIIC stages, but not in TNM IV stage.…”

Section: Discussionsupporting

confidence: 89%

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Prognostic significance and the role in TNM stage of extranodal metastasis within regional lymph nodes station in gastric carcinoma

et al. 2016

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The role of extranodal metastasis (ENM) in TNM stage in gastric carcinoma (GC) is controversial. This study was aimed to make a detailed investigation of the prognostic significance and the role in TNM stage of ENM in GC. The patients with primary GC, who underwent gastrectomy with curative intention in West China Hospital from January 2005 to December 2011, were retrospectively enrolled. The prognosis and clinicopathological traits were compared between ENM positive (ENMP) and negative (ENMN) groups in all patients, TNM I-II, III and IV stages, respectively. The significance of the number and the role in TNM stage of ENM were also assessed. In our study, 1457 patients were enrolled, with 1324 (90.9%) in ENMN group and 133 (9.1%) in ENMP group. ENMP group had significantly more advanced GC and worse prognosis (all p<0.05) than ENMN group in all patients, TNM I-II stages and TNM III stage. ENM>2 subgroup had remarkably larger tumor size (p=0.002) and more advanced N stage (p=0.016) than ENM=1-2 subgroup. The number of ENM was an independent prognostic factor in ENMP group (p=0.029). The prognosis of ENM>2 in TNM I-III stages was significantly worse than ENMN patients in TNM III stage. The C-index of TNM stage plus the number of ENM was significantly higher than that of current TNM stage alone (p=0.005). In conclusion, the patients in ENMP subgroup had more advanced GC and worse prognosis than those in ENMN subgroup. It might be more reasonable to categorize ENM>2 into TNM IV stage.

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Section: Discussionsupporting

confidence: 89%

“…Nevertheless, the role of the number of ENM was investigated only in few studies [3]. Besides, many studies had relative small sample sizes or were only limited in lymph node positive patients [8, 9]. A detailed research of ENM in GC is still expected.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance and the role in TNM stage of extranodal metastasis within regional lymph nodes station in gastric carcinoma

et al. 2016

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“…In a series of 228 colorectal advanced carcinoma cases, Puppa et al identified tumor deposits in 43.85% of the cases. Tumor deposits were found in 17.8%, 23.9%, and 24% of cases in different studies of gastric carcinomas . If this is the case for adenocarcinomas of the gastrointestinal tract, it should perhaps come as no surprise that tumor deposits are also observed in HNSCCs.…”

Section: Discussionmentioning

confidence: 97%

Tumor deposits in head and neck carcinomas

et al. 2015

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“…Although they are encountered in some types of adenocarcinoma, including gastric, biliary, and pancreatic [12, 13] the prognostic significance of TDs has been studied mainly in colorectal carcinomas [8, 14–20]. Currently, TDs are part of the TNM classification of colorectal carcinomas [5].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of perigastric tumor deposits in patients with primary gastric cancer

et al. 2017

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BackgroundThe presence and the prognostic significance of perigastric tumor deposits (TDs) in primary gastric cancer have not been extensively studied. The aim of this study was to evaluate the prognostic significance perigastric TDs in primary gastric cancer.MethodsFrom 2005 to 2010, 1250 patients underwent R0 gastrectomy at the Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China. Out of 1250 patients, 132 patients with perigastric TDs were identified. Additionally, 132 patients with staged matched gastric cancer without tumor deposits were selected as a control group.ResultsPerigastric TDs were observed in 132 (10.5%) of the 1250 patients with gastric cancer who underwent R0 gastrectomy. There were 94 males (71.21%) and 38 females (28.79%) (2.47:1). The mean age was 57.21 years. Clinicopathologic characteristics between the two groups matched well. There was a significant difference in the overall survival of those with and without TDs by univariate (p<0.05) and multivariate (p < 0.05) survival analysis. The 1-, 3-and 5-year overall survival rates of patients with TDswere69.6%, 39.3%, and 24.2%, respectively, and were significantly poorer than those of the staged matched control group. There was no correlation between the number of TDs and patient survival in patients with gastric cancer (p>0.05); however, when comparing each pT tumor group with the perigastric TD group, the stage T4 survival rate was very similar to that observed in patients with TDs.ConclusionsPerigastric TDs are an independent predictive prognostic factor for gastric cancer and may be appropriately considered a form of serosal invasion. We suggest that TDs should be included in TNM staging system for better outcomes.Electronic supplementary materialThe online version of this article (doi:10.1186/s12893-017-0280-4) contains supplementary material, which is available to authorized users.

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Tumor deposits in gastric carcinomas

Cited by 28 publications

References 21 publications

Prognostic significance and the role in TNM stage of extranodal metastasis within regional lymph nodes station in gastric carcinoma

Prognostic significance and the role in TNM stage of extranodal metastasis within regional lymph nodes station in gastric carcinoma

Tumor deposits in head and neck carcinomas

Prognostic significance of perigastric tumor deposits in patients with primary gastric cancer

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