Tumor de Wilms: revisión de nuestra experiencia en los últimos 15 años

Illade, Laura; Hernández-Marqués, Carmen; Cormenzana, M.; Lassaletta, Álvaro; Catalán, Maitane Andión; Ruano, David; Fioravantti, Victoria; López, L. Madero

doi:10.1016/j.anpedi.2017.03.019

Cited by 13 publications

(8 citation statements)

References 20 publications

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“…In this study, DAWT tissue exhibited low miR-181 expression, which would be expected to lead to reduced VCAM-1 inhibition, thereby increasing the likelihood of tumor cell invasion and migration in DAWT (35). These observations are in agreement with estimates indicating that 50% of patients with DAWT develop metastasis (36).…”

Section: Discussionsupporting

confidence: 89%

MicroRNA Profiling in Wilms Tumor: Identification of Potential Biomarkers

et al. 2020

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Wilms tumor (WT) is the most frequently diagnosed malignant renal tumor in children. With current treatments, ∼90% of children diagnosed with WT survive and generally present with tumors characterized by favorable histology (FHWT), whereas prognosis is poor for the remaining 10% of cases where the tumors are characterized by cellular diffuse anaplasia (DAWT). Relatively few studies have investigated microRNA-related epigenetic regulation and its relationship with altered gene expression in WT. Here, we aim to identify microRNAs differentially expressed in WT and describe their expression in terms of cellular anaplasia, metastasis, and association with the main genetic alterations in WT to identify potential prognostic biomarkers. Expression profiling using TaqMan low-density array was performed in a discovery cohort consisting of four DAWT and eight FHWT samples. Relative quantification resulted in the identification of 109 (48.7%) microRNAs differentially expressed in both WT types. Of these, miR-10a-5p, miR-29a-3p, miR-181a-5p, miR-200b-3p, and miR-218-5p were selected and tested by RT-qPCR on a validation cohort of 53 patient samples. MiR-29a and miR-218 showed significant differences in FHWT with low (P = 0.0018) and high (P = 0.0131) expression, respectively. To discriminate between miRNA expression FHWTs and healthy controls, the receiver operating characteristic (ROC) curves were obtained; miR-29a AUC was 0.7843. Furthermore, low expression levels of miR-29a and miR-200b (P = 0.0027 and P = 0.0248) were observed in metastatic tumors. ROC curves for miR-29a discriminated metastatic patients (AUC = 0.8529) and miR-200b (AUC = 0.7757). To confirm the differences between cases with poor prognosis, we performed in situ hybridization for three microRNAs in five DAWT and 17 FHWT samples, and only significant differences between adjacent tissues and FHWT tumors were found for miR-181a, miR-200b, and miR-218, in both total pixels and nuclear analyses. Analysis of copy number variation in genes showed that the most prevalent alterations were WTX (47%), IGF2 (21%), 1q (36%) gain, 1p36 (16%), and WTX deletion/1q duplicate (26%). The five microRNAs evaluated are involved in the Hippo signaling pathway and participate in Wilms tumor development through their effects on differentiation, proliferation, angiogenesis, and metastasis.

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Section: Discussionsupporting

confidence: 89%

MicroRNA Profiling in Wilms Tumor: Identification of Potential Biomarkers

et al. 2020

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“…In Europe, preoperative chemotherapy is followed by surgical removal, with or without postoperative radiation treatment, depending on the phase and histology of the tumour. The diagnosis of Wilms tumor is based on clinical and radiological characteristics [6].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case Report on Therapeutic Management of Wilm’s Tumour

Rewatkar

Patil

2021

JPRI

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Introduction: Wilms's tumour was named after Carl Max Wilhelm Wilms, a 19th century German surgeon. Wilm’s tumor is derived from primitive metanephric blastema and is a form of childhood carcinoma that begins in the kidneys (also called nephroblastoma). In infants, it is the most common form of kidney carcinoma. 9 out of 10 kidney cancers in kids is Wilms Tumor. Carcinoma can spread to other parts of the body. The incidence is around seven new cases per million children in the United States, with a peak incidence between the ages of 2 and 3 years. Main symptoms and important clinical findings: A 11 yrs. old female child was admitted in Acharya Vinoba Bhave Rural Hospital, Wardha on 08/02/2021 with chief complaint of breathing difficulty, shortness of breath, blood in the urine, nausea and vomiting. After physical examination and investigations, doctors diagnosed it as a case of Wilm’s tumor. The main diagnoses, therapeutic interventions and outcomes: After physical examination and investigations like MRI, doctor diagnosed it as a case Wilm’s tumour. Tab. Actinomycin D (Dactinomycin), tab. Vincristine (chemotherapy) were started and calcium and multivitamin supplements were given for 7 days to enhance immune function. Tab. Septran 160 mg OD and tab. Acenet 400 mg OD, tab. Bactrim 5mg OD was also prescribed. Patient took all treatment and outcome was good. Her signs and symptoms improved. Conclusion: Accurate diagnosis and timely initiation of treatment speeded up recovery.

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“…4 The most common clinical presentation was abdominal and lumbar pain, followed by abdominal mass, fever, and hematuria, also similar to what was observed in other studies. 10,11 The prevalent histology type was mixed nephroblastoma. All patients received presurgery chemotherapy followed by, in most cases, unilateral total nephrectomy.…”

Section: Discussionmentioning

confidence: 99%

Wilms tumor: 15 years of experience at a children’s hospital in Córdoba, Argentina

et al. 2019

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The objective of this study was to describe the epidemiology, clinical presentation, treatment and nephrology follow-up of children with Wilms tumor. Data from 46 patients were collected. The clinical presentation occurred at a young age (< 40 months old), with initial symptoms of pain, abdominal mass, and fever. The prevalent histology type was mixed nephroblastoma. All patients received pre-surgery chemotherapy followed by, in most cases, unilateral nephrectomy. Patients with a high histological risk had a 7.2 relative risk of death (75 % confidence interval: 1.5-33.7) compared to the rest, and a 2.5 relative risk of recurrence (75 % confidence interval: 1.0-6.4). Disease-free survival at 5 years was 70 %. Once cancer treatment was completed, 80 % of patients maintained a stage-I kidney function. The most important prognostic factor was histology. These patients required a long-term nephrology follow-up.

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Tumor de Wilms: revisión de nuestra experiencia en los últimos 15 años

Abstract: Wilms' tumour treatment is a success of modern medicine, currently achieving a survival rate of 95% in our series.

Cited by 13 publications

References 20 publications

MicroRNA Profiling in Wilms Tumor: Identification of Potential Biomarkers

MicroRNA Profiling in Wilms Tumor: Identification of Potential Biomarkers

A Rare Case Report on Therapeutic Management of Wilm’s Tumour

Wilms tumor: 15 years of experience at a children’s hospital in Córdoba, Argentina

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