Tumor de células gigantes localmente avançado ao nível do joelho: tratamento e revisão da literatura

Rigollino, Ana Valeria; Fernando, Thiago Santos; Tanaka, Marcos Hajime; Souza, Marcello Martins de

doi:10.1016/j.rbo.2016.07.013

Cited by 11 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Es importante entender que un riesgo para una recidiva es la presencia de una fractura patológica por contaminación de tejidos blandos, entendiendo este como un factor de riesgo [25] como el caso de este paciente. Dentro de la bibliografía actual la recomendación en el manejo de TCG grado III de Campanacci es la resección en bloque y reconstrucción del defecto mediante endoprotesis no convencionales [26], sin embargo la utilidad de realizar reconstrucción con injertos es una opción terapéutica útil en pacientes jóvenes, evidenciando la evolución clínica y radiológica favorable, abriendo las puertas para la aplicación de nuevas técnicas y tratamientos.…”

Section: Publonsunclassified

Caso Clínico: Uso de Aloinjerto Óseo Estructural en Tumor de Células Gigantes de Fémur

et al. 2018

View full text Add to dashboard Cite

BACKGROUND: Bone giant cell tumor (GCT) is one of the least frequent, most controversial and least predictable tumors in its behavior. We present a case of GCT in the lower limb, which implied the distal femur. The diagnosis required a previous biopsy before proceeding with its en bloc resection, and treatment based on bone allograft. CASE REPORT: Male patient of 43 years of age, mestizo, with no relevant personal or family history. He went to the oncology orthopedics outpatient clinic for presenting a hard and painful mass with gradual increase in size at the level of the right knee, deformity, functional limitation and crepitus in that region, which is why he attends his assessment. EVOLUTION: The patient underwent a lesion biopsy at the level of the distal femur with a pathological anatomy report of giant cell tumor. Bone resection was performed at the tumor level and treatment was performed by allografting the bone structural allograft. A 2-year follow-up was performed and a score of 14/15 according to the Makin scale was obtained as functional results. Osteointegration of the graft to autogenous bone was also evidenced. Excellently at 15 months. We did not find infection, graft resorption or fatigue of the material. CONCLUSIONS: Limb preservation surgery represented by structural allografts is a favorable technique with adequate functionality and osteoingration, increasing the life expectancy of our patients and future revision possibilities. Avoiding amputations, arthrodesis or tumor prosthesis whose cost benefit with the subsequent years end up being high and deteriorating the quality of life in the patient.

show abstract

Section: Publonsunclassified

Caso Clínico: Uso de Aloinjerto Óseo Estructural en Tumor de Células Gigantes de Fémur

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Current knowledge of GCTB surgical outcomes has been based on major world series (Deheshi et al, 2007;Balke et al, 2009;Ferraz et al, 2016). On the other hand, there is a lack of Brazilian epidemiological and surgical data on this specific type of neoplasm, except for a few series of cases (Camargo et al, 2001;Baptista et al, 2001;Catalan et al, 2006;Rigollino et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Giant cell tumor of bone: Epidemiological profile (fifth version) – A study protocol

Becker

Pereira

Gália

et al. 2022

RSD

View full text Add to dashboard Cite

The giant cell tumor of bone (GCTB) represents approximately 5% of primary bone tumors, and more than half of cases affect individuals between 20 and 50 years of age. Despite being a benign neoplasm, 3 to 5% of cases may show pulmonary metastases, besides it has high potential for bone destruction at the main site of the lesion, often in the epiphyses of long bones, which may lead to serious functional problems in affected patients. Multidisciplinary treatment of GCTB has been a cause for discussion in the last decade due to the discovery of drugs such as denosumab that prevent tumor progression and may be useful in cases of patients with local recurrences and unresectable tumors. The therapeutic basis of GCTB remains the isolated surgical treatment by intralesional (with adjuvants), marginal or wide resection. Intralesional treatment presents higher rates of recurrence, however it preserves the adjacent joint function and much of the individual bone stock. Resection with wide margins presents lower recurrence rates but has shown worse functional results and frequent complications in bone reconstructions. Current knowledge of GCTB surgical outcomes has been based on major world series - there is a lack of Brazilian epidemiological and surgical data on this specific type of neoplasm, except for a few series of cases. The primary objective of this paper is to identify the epidemiological profile of GCTB; the secondary objectives are to describe the surgical aspects in the main diagnostic centers and treatment of bone tumors, to analyze the clinical and surgical aspects of patients with GCTB of wrist and hand, and to analyze the clinical and surgical aspects of patients with knee GCTB. These findings may help in the maintenance or change of national guidelines for the treatment of GCTB. This study protocol was submitted to ethical assessment under the CAAE (Ethical Appreciation Presentation Certificate) registry No. 94280918.0.0000.5327 (5th version), evaluated through the substantiated opinion No. 4.770.705, and approved by the Institutional Research Ethics Committee on June 12, 2022.

show abstract

Increased Risk of Lung Metastases in Patients with Giant Cell Bone Tumors: A Systematic Review

Yayan

2019

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Tumor de células gigantes localmente avançado ao nível do joelho: tratamento e revisão da literatura

Cited by 11 publications

References 13 publications

Caso Clínico: Uso de Aloinjerto Óseo Estructural en Tumor de Células Gigantes de Fémur

Caso Clínico: Uso de Aloinjerto Óseo Estructural en Tumor de Células Gigantes de Fémur

Giant cell tumor of bone: Epidemiological profile (fifth version) – A study protocol

Increased Risk of Lung Metastases in Patients with Giant Cell Bone Tumors: A Systematic Review

Contact Info

Product

Resources

About