“…Interestingly, abnormal vascularization has been associated not only with pronounced proliferation of endothelial cells [60] and hypoxia [11,61], but also with an elevated Gal-1 expression [62,63]. In fact, studies have shown that Gal-1 can induce endothelial cell proliferation [64,65] and that Gal-1 expression can be regulated by hypoxia [66,67]. Also of significance, some studies have provided evidence that local hypoxia not only promotes keratinocyte motility and migration during wound healing [68] but also stimulates the deposition of collagen by fibroblasts in wounds and keloids [69][70][71] and abnormal vascularization in keloids [11].…”