2019
DOI: 10.1158/2326-6066.cir-18-0891
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Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth

Abstract: Clear-cell renal cell carcinoma (ccRCC) possesses an unmet medical need, particularly at the metastatic stage, when surgery is ineffective. Complement is a key factor in tissue inflammation, favoring cancer progression through the production of complement component 5a (C5a). However, the activation pathways that generate C5a in tumors remain obscure. By data mining, we identified ccRCC as a cancer type expressing concomitantly high expression of the components that are part of the classical complement pathway.… Show more

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Cited by 178 publications
(177 citation statements)
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“…Indeed, in the seminal paper describing the pro-tumoral role of complement, a lung epithelial cell line was used (TC-1) and the complement activation was nailed down to a C4-dependent classical or lectin pathways 20 . Recently, we found that it was the classical pathway that was activated in this model 21 . In other lung cancer mouse models, the classical pathway was also activated, likely by intratumoral immunoglobulins 22 .…”
Section: Canonical Mechanisms Of Initiationmentioning
confidence: 71%
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“…Indeed, in the seminal paper describing the pro-tumoral role of complement, a lung epithelial cell line was used (TC-1) and the complement activation was nailed down to a C4-dependent classical or lectin pathways 20 . Recently, we found that it was the classical pathway that was activated in this model 21 . In other lung cancer mouse models, the classical pathway was also activated, likely by intratumoral immunoglobulins 22 .…”
Section: Canonical Mechanisms Of Initiationmentioning
confidence: 71%
“…To date the best examples of "aggressive complement" tumors, for which genes expression and bioinformatics analyses corroborate with assessment at protein level in situ are KIRC and non-small cell lung cancer (NSCLC). In both cases all components for classical pathway activation could be produced intratumorally and classical pathway activation, detected by presence of C1q and C4d-positive deposits was associated with poor prognosis 21,90 .…”
Section: Cancers With "Protective C3"mentioning
confidence: 95%
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