Tumor cell proliferation and sequential chemotherapy after partial tumor resection in C3H/HeJ mammary tumors

Abstract

SummaryChanges in tumor cell proliferation and chemosensitivity after partial (up to 3/4) surgical resection were studied in C3H/HeJ mammary tumors, In all studies surgical cytoreduction stimulated tumor cell proliferation in the residual tumor, as evidenced by increases in the 3H-TdR labelling index between 24 and 72 hrs after surgery. The time of maximal proliferative activity was directly related to the amount of tumor removed. In spontaneous mammary tumors, proliferative recovery after 1/2 resection could be delayed by giving dexamethasone 24 hrs after resection. The regrowth delay after surgery and various combinations of dexamethasone, vincristine, 5-FU, and cyclophosphamide, was used to assess the significance of the kinetic ,changes in the residual tumor for the design of adjuvant therapeutic strategies.The results indicated that the chemosensitivity of C3H/HeJ mammary tumors was substantially increased after surgical cytoreduction, and that these post-surgical changes were directly correlated with changes in tumor cell proliferative activity.

Survival benefit of radiotherapy after surgery in de novo stage IV breast cancer: a population-based propensity-score matched analysis

“…However, the local treatment group had a significantly worse distant progression-free survival, resulting in no difference in OS between the two groups. This was correlated to the treatment-provoked growth of a metastatic tumor after local treatments to the primary site 27–29 . In this study, patients were treated with systemic chemotherapy before randomization, and only responsive patients were enrolled.…”

Locoregional Surgery in Metastatic Breast Cancer: Do Concomitant Metabolic Aspects Have a Role on the Management and Prognosis in this Setting?

“…Moreover, the 2-year overall survival was 41.9% in the locoregional treatment and 43% in the no-locoregional treatment, and, furthermore, only 18% of patients who had undergone locoregional treatment required palliative surgery [ 19 ]. Finally, they found a reduction of progression-free survival in the group that had undergone locoregional treatment, hypothesizing that this was determined by the growth of the metastatic tumor as a result of the removal of the primary tumor, as showed by other preclinical studies [ 20 , 21 , 22 , 23 ]. The authors concluded that they did not find any evidence to support the use of surgical locoregional treatment to improve overall survival in MBC patients who responded to first-line chemotherapy and suggested not to consider this procedure in routine practice.…”

The role of primary surgery in metastatic breast cancer at presentation

“…5. Tümör mikroçevrede cerrahi travma sonucu büyüme faktörlerinin salgılanması hipotezi Coffey ve ark (21)'larının yayınladıkları derlemede postoperatif immünsupresyon, cerrahi sırasında tümör hücrelerinin dolaşıma katılması, lipopolisakkaritlerin etkisiyle proenflamatuar cevabın oluşması ve dolaşımda interlökin 6, VEGF ve TNF alfa salınması, anjiojenik değişim gibi faktörlerin biri veya kombinasyonunun primer tümörün çıkarılmasından sonra metastazların büyümesine katkı yapabileceği ifade edilmektedir (18,19,(21)(22)(23). Primer tümör genellikle ekstrasellüler matriks proteaz, glikojenaz, proanjiojenetik faktörler, enflamatuar ve anjiojenetik mediyatörler üretmekte ve böylece mikroçevrede değişime neden olmaktadır.…”