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Cited by 179 publications
(122 citation statements)
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References 101 publications
(162 reference statements)
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“…Similarly, demand for glutamine is greater than other nonessential amino acids in cancer cells (Coles and Johnstone, 1962). These alterations are characterized by redistribution of glucose carbons away from catabolism for ATP production toward macromolecule synthesis and maintenance of reductive capacity to sustain proliferation (Romero‐Garcia et al ., 2011). In addition to enhanced glucose and glutamine metabolism, alterations in cancer cell fatty acid (FA) metabolism have been reported (Balaban et al ., 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Similarly, demand for glutamine is greater than other nonessential amino acids in cancer cells (Coles and Johnstone, 1962). These alterations are characterized by redistribution of glucose carbons away from catabolism for ATP production toward macromolecule synthesis and maintenance of reductive capacity to sustain proliferation (Romero‐Garcia et al ., 2011). In addition to enhanced glucose and glutamine metabolism, alterations in cancer cell fatty acid (FA) metabolism have been reported (Balaban et al ., 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Tumors contain both aerobic and hypoxic regions that form a metabolic symbiosis that is crucial for tumor cell survival (15,16). The cancer cells located in the hypoxic regions export lactate, which acidifies the tumor environment; the cells located in the aerobic regions, however, import lactate and utilize it for oxidative phosphorylation (4).…”
mentioning
confidence: 99%
“…Így a tejsav hozzájárul a mitochondrialis mechanizmus felerősítéséhez, a daganatkép-ződéshez és a progresszióhoz [40,41]. Továbbá a tejsav közvetetten elősegíti a hypoxiás daganatsejtek túlélését, amelyek az újonnan képződött erektől távol helyezkednek el [42]. Humán daganatokban -mint glioma, emlő-rák, CRC, gyomor-, méhnyakrák és neuroblastoma -fokozott MCT1-és MCT4-expressziót figyeltek meg, amely rossz prognózissal társult [43][44][45][46].…”
Section: A Tejsav Mint a Daganatsejt Energiaforrásaunclassified