Tumor budding may be a promising prognostic indicator in intrahepatic cholangiocarcinoma: A multicenter retrospective study

Kosaka, Hisashi; Ishida, Mitsuaki; Ueno, Masaki; Koyama, Koji; Hokuto, Daisuke; Iida, Hiroya; Hirokawa, Fumitoshi; Matsui, Kosuke; Sekimoto, Mitsugu; Kaibori, Masaki

doi:10.1002/ags3.12605

Cited by 8 publications

(8 citation statements)

References 24 publications

(77 reference statements)

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“…TB is also an important prognostic indicator in CRC, and the prognostic significance of TB has also been reported in other types of carcinomas, regardless of the histological type of cancer (both adenocarcinoma and squamous cell carcinoma) (18)(19)(20)(21)(22). For example, Noda et al recently analyzed the significance of DR, TB, tumor-infiltrating lymphocytes, and depth of invasion of oral squamous cell carcinoma to determine its ability to predict extranodal extension, which is an important indicator of poor prognosis for this type of carcinoma (21).…”

Section: Discussionmentioning

confidence: 89%

Significance of desmoplastic reactions on tumor deposits in patients with colorectal cancer

et al. 2022

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It has been well recognized that the tumor microenvironment serves important roles in the progression and invasion of cancer. The desmoplastic reaction (DR) is a fibrous tissue reaction around tumor cells, and the prognostic significance of DR in colorectal cancer (CRC) has been established. Tumor deposits (TD) are also an important prognostic indicator of CRC. Notably, immature type DR has been linked to poor prognosis. In addition, immature type DR is significantly associated with a higher pT stage, presence of lymphovascular invasion and lymph node metastasis; however, to the best of our knowledge, the association between DR and TD has not yet been examined. The present study aimed to clarify this association. This study included 443 consecutive patients with pT3 or pT4 CRC who underwent surgical resection. The histopathological features, including DR and TD, were evaluated. Statistical analyses of the presence of TD, DR and other clinicopathological parameters were performed. The present cohort included 205 female and 238 male patients; 293 (66.1%) and 150 (33.9%) patients were classified as pT3 and pT4, respectively. Immature, intermediate and mature DR were noted in 282 (63.7%), 91 (20.5%) and 70 patients (15.8%), respectively. TD was observed in 93 (21.0%) patients. Immature type DR was significantly associated with a higher pT stage (P<0.0001), presence of lymph node metastasis (P<0.0001), lymphatic (P=0.0007), venous (P<0.0001) and perineural invasion (P<0.0001), and higher tumor budding (TB) (P<0.0001). Moreover, immature type DR was significantly associated with the presence of TD (P<0.0001). The present study demonstrated a significant association between immature type DR and the presence of TD, and suggested a close relationship between lymphovascular invasion, DR, TB and TD. Additional studies are required to analyze the detailed mechanism underlying the development of immature DR in CRC to define novel treatment strategies.

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Section: Discussionmentioning

confidence: 89%

Significance of desmoplastic reactions on tumor deposits in patients with colorectal cancer

et al. 2022

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“…Subsequently, a full‐text review was performed, during which studies with inadequate data or cohort presentation, as well as those lacking full‐text availability, the inadequate study design was excluded. Ultimately, 57 studies met our inclusion criteria and were included in our systematic review and meta‐analysis 4,5,16–70 . Manual‐checking references to ensure comprehensives did not yield any additional studies.…”

Section: Resultsmentioning

confidence: 99%

Prognostic significance of tumour budding in noncolorectal gastrointestinal tract and pancreatobiliary tract: a systematic review and meta‐analysis

Park,

Shin,

Lim

2024

Histopathology

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Tumour budding shows promise as a prognostic factor in various cancers, but its widespread application is hindered by the lack of large, validated studies and standardized criteria. This meta‐analysis aims to review and examine the prognostic role of tumour budding specifically in noncolorectal gastrointestinal and pancreatobiliary tract cancers, broadening our perspective on its clinical relevance. The literature review was conducted through PubMed, Embase, and Web of Science from inception till 20 February 2023. Pooled odds ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) were calculated to assess the relation between tumour budding and clinicopathologic features, as well as overall survival. Each study was evaluated using the Newcastle‐Ottawa Scale and both heterogeneity and publication bias were analysed. In this meta‐analysis of 57 studies across various cancer types, multivariate HR revealed worse overall survival in oesophageal squamous cell carcinoma (HR 3.34 [95% CI 2.21–5.04]), gastric adenocarcinoma (2.03 [1.38–2.99]), pancreatic ductal adenocarcinoma (2.56 [2.02–3.25]), and biliary tract adenocarcinoma (3.11 [2.46–3.93]) with high‐grade tumour budding. Additionally, high‐grade tumour budding consistently correlated with adverse clinicopathological features, including lymph node metastasis, lymphovascular invasion, and distant metastasis without any observed inverse association. High heterogeneity was noted. Our study suggests that tumour budding is a valuable prognostic marker in various cancers. Nonetheless, standardized criteria tailored to specific organ types are necessary to enhance its clinical utility.

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“…Most of these studies classified TB into low and intermediate/high groups based on the cut-off value of 5 [ 11 , 12 , 14 , 15 , 18 ]. Conversely, Kosaka et al reported a difference in the survival outcomes between low/intermediate and high TB groups, using a cut-off value of 10 in their multicenter study [ 13 ]. As in Kosaka’s study, we divided patients with TB into low/intermediate and high groups.…”

Section: Discussionmentioning

confidence: 99%

“…By introducing this concept, studies on the prognostic significance of TB in various cancer types, such as pancreatic, gallbladder, esophageal, and gastric cancers, have been conducted [7][8][9][10]. Although relevant studies have recently been performed to evaluate the importance of TB in CC, the number remains limited, and only 10 papers have been published to date (as of March 2023) [11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Tumor budding as a predictor of disease-free survival in patients with cholangiocarcinoma

Kim

Ahn

Kwon

et al. 2023

Pathol. Oncol. Res.

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Background: Tumor budding is considered a prognostic factor in several solid cancer types. However, we lack comprehensive information on the importance of tumor budding in cholangiocarcinoma. Therefore, we aimed to assess the prognostic value of tumor budding in intrahepatic and extrahepatic cholangiocarcinomas and to evaluate its correlations with other clinicopathological parameters.Methods: We monitored 219 patients who underwent surgery for intrahepatic or extrahepatic cholangiocarcinoma at the Pusan National University Hospital between 2012 and 2021. Tumor budding was evaluated using the International Tumor Budding Consensus Conference scoring system. Tumor budding was classified into low (0–4), intermediate (5–9), and high (≥10). For statistical analysis, tumor budding was divided into two groups based on the cut-off value of 10 (lower: 0–9 vs. higher: ≥10). The correlations between clinicopathological parameters were examined using the chi-square and Fisher’s exact test. The prognostic values of the variables were analyzed using the log-rank test and Cox regression analysis.Results: Low, intermediate, and high tumor buddings were identified in 135 (61.6%), 63 (28.8), and 21 (9.6%), patients, respectively. Higher tumor budding was related to the presence of lymphatic invasion (p = 0.017), higher tumor grade (p = 0.001), higher N category (p = 0.034). In the univariable and multivariable analyses, higher tumor budding was associated with shorter disease-free survival in 97 (44.3%) patients who underwent R0 resection (p < 0.001 and p = 0.011). Tumor budding did not significantly correlate with disease-specific survival in entire patients.Conclusion: Tumor budding may serve as a prognostic factor for intrahepatic and extrahepatic cholangiocarcinomas treated with R0 resection.

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Tumor budding may be a promising prognostic indicator in intrahepatic cholangiocarcinoma: A multicenter retrospective study

Cited by 8 publications

References 24 publications

Significance of desmoplastic reactions on tumor deposits in patients with colorectal cancer

Significance of desmoplastic reactions on tumor deposits in patients with colorectal cancer

Prognostic significance of tumour budding in noncolorectal gastrointestinal tract and pancreatobiliary tract: a systematic review and meta‐analysis

Tumor budding as a predictor of disease-free survival in patients with cholangiocarcinoma

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