Tumor budding in laryngeal carcinoma

Ekmekçi, Sümeyye; Küçük, Ülkü; Kokkoz, Seda Eryiğit; Çakır, Ebru; Gümüşsoy, Murat

doi:10.4103/ijpm.ijpm_428_17

Cited by 8 publications

(10 citation statements)

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“…The phenomenon “tumor budding” is regarded as a specific “signal” indicating the onset of cancer invasion and metastasis. The presence of tumor buds in the invasive front was found to be associated with increased metastasis and poor prognosis in various cancers [28,29,30,31,32,33,34].…”

Section: Introductionmentioning

confidence: 99%

Markers of Cancer Cell Invasion: Are They Good Enough?

Gerashchenko

Novikov

Krakhmal

et al. 2019

JCM

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Invasion, or directed migration of tumor cells into adjacent tissues, is one of the hallmarks of cancer and the first step towards metastasis. Penetrating to adjacent tissues, tumor cells form the so-called invasive front/edge. The cellular plasticity afforded by different kinds of phenotypic transitions (epithelial–mesenchymal, collective–amoeboid, mesenchymal–amoeboid, and vice versa) significantly contributes to the diversity of cancer cell invasion patterns and mechanisms. Nevertheless, despite the advances in the understanding of invasion, it is problematic to identify tumor cells with the motile phenotype in cancer tissue specimens due to the absence of reliable and acceptable molecular markers. In this review, we summarize the current information about molecules such as extracellular matrix components, factors of epithelial–mesenchymal transition, proteases, cell adhesion, and actin cytoskeleton proteins involved in cell migration and invasion that could be used as invasive markers and discuss their advantages and limitations. Based on the reviewed data, we conclude that future studies focused on the identification of specific invasive markers should use new models one of which may be the intratumor morphological heterogeneity in breast cancer reflecting different patterns of cancer cell invasion.

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Section: Introductionmentioning

confidence: 99%

Markers of Cancer Cell Invasion: Are They Good Enough?

Gerashchenko

Novikov

Krakhmal

et al. 2019

JCM

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“…The cutoffs and criteria in our study have been adapted from the guideline for budding assessment in colorectal carcinomas [18]. Studies on tumor budding in laryngeal SCCs have rarely been done before [19,20]. Ekmekci et al found that perineural, lymphovascular invasion and nodal metastasis had a significant correlation with tumor budding, however, none of the other parameters were significant, nor was the survival [19].…”

Section: Discussionmentioning

confidence: 99%

Tumor Budding Assessment with Cytokeratin and Its Significance in Laryngeal Squamous Cell Carcinomas

Gupta

Sreeram

Pinto

et al. 2021

Indian J Otolaryngol Head Neck Surg

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There is a need for novel prognostic parameters in assessing laryngeal squamous cell carcinoma (LSCC). Tumor budding is an instrumental parameter, which has hardly been studied before in this organ. This study aimed to assess tumor budding in LSCCs with routine hematoxylin and eosin (H&E) stain as well as cytokeratin (CK) immunohistochemistry (IHC). Objectives were to compare the effectiveness of both these methods to assess tumor budding, to investigate the association of tumor budding and clinicopathologic features, and to determine the prognostic significance of tumor budding in LSCCs. Fifty laryngectomy specimens were included. Tumor budding was counted (20x) on slides stained with IHC-CK, and highest count per slide was noted. The cases were classified as positive ([ 1 buds) or negative (no buds present). The budding index was categorized as low (\ 5 buds) or high ([ 5 buds). Tumor budding on H&E was absent, low and high grade in 28%, 30% and 42% cases respectively, when compared to CK-IHC in 17%, 24% and 59% of cases, respectively. Presence of lymphoplasmacytic infiltration significantly correlated with tumor budding and higher grade. Transglottic location of tumor and pT stage was associated with high budding. Presence of lymphoplasmacytic infiltrate significantly correlated with worse prognosis. Tumor budding, an easily assessable, inexpensive histopathologic parameter has seldom been studied in LSCCs. Presence of lymphoplasmacytic infiltrate in routine preoperative biopsy reporting could be useful in prognostication. CK-IHC is helpful to detect especially cases with low-grade tumor budding.

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“…28 Further, the findings in these reports have been based on large patient cohorts. [34][35][36] In hypopharyngeal cancer, Boxberg et al 35 reported a significant prognostic value for tumor budding in an analysis of patient cohort of laryngeal and hypopharyngeal subsites. 10 Subsequently, after that meta-analysis many studies have been published indicating that tumor budding is a promising prognostic marker in OSCC, 21,[29][30][31][32] including the recent meta-analysis with tumors from various subsites of the head and neck.…”

Section: Tumor Budding As a Simple Promising Prognostic Marker In Hmentioning

confidence: 99%

“…More recent studies have confirmed the prognostic value of tumor budding in laryngeal cancer. [34][35][36] In hypopharyngeal cancer, Boxberg et al 35 reported a significant prognostic value for tumor budding in an analysis of patient cohort of laryngeal and hypopharyngeal subsites. Similar results on the significance of tumor budding were reported in an independent cohort of hypopharyngeal SCC by Imai et al, 11 and also for pharyngeal SCC by Karpathiou et al 34 Specifically, identification of high intensity of tumor budding in HNSCC has been associated with metastasis to cervical lymph nodes.…”

Section: Tumor Budding As a Simple Promising Prognostic Marker In Hmentioning

confidence: 99%

Hallmarks of cancer: Tumor budding as a sign of invasion and metastasis in head and neck cancer

et al. 2019

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Invasion and metastasis are hallmarks of cancer. The concept of tumor budding at tumor‐host interface has been documented in many carcinomas. A growing body of evidence indicates that tumor budding is a sign of invasion and early step for metastasis of many epithelial cancers including head and neck squamous cell carcinoma (HNSCC). In addition, recent research has underlined the importance of tumor budding as a promising prognosticator in HNSCC. This review summarizes the findings regarding tumor budding in HNSCC and focuses on the role of tumor budding in invasion and metastasis. Also, we highlight the prognostic significance of tumor budding in HNSCC and its potential for improving clinical decision making in terms of recommending optimal individualized treatment for this patient population.

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Tumor budding in laryngeal carcinoma

Cited by 8 publications

References 0 publications

Markers of Cancer Cell Invasion: Are They Good Enough?

Markers of Cancer Cell Invasion: Are They Good Enough?

Tumor Budding Assessment with Cytokeratin and Its Significance in Laryngeal Squamous Cell Carcinomas

Hallmarks of cancer: Tumor budding as a sign of invasion and metastasis in head and neck cancer

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