Tumor blood vessel visualization

Missbach-Guentner, Jeannine; Hunia, Julia; Alves, Frauke

doi:10.1387/ijdb.103229jm

Cited by 18 publications

(17 citation statements)

References 84 publications

(96 reference statements)

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“…Thus, imaging of angiogenesis is becoming of great interest to visualize and quantify angiogenic activity in nascent tumors [2]. During the last decade, emergence of molecular imaging has raised much enthusiasm to assess cellular and molecular processes in living tissues, and particularly to detect specific biomarkers of malignant neoplasms [3]. A well-known biomarker of neovascular proliferation is a m b 3 integrin.…”

Section: Introductionmentioning

confidence: 99%

19F molecular MR imaging for detection of brain tumor angiogenesis: in vivo validation using targeted PFOB nanoparticles

et al. 2012

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Molecular imaging with magnetic resonance imaging (MRI) targeted contrast agents has emerged as a promising diagnostic approach in cancer research to detect associated biomarkers. In this work, the potential of (19)F MRI was investigated to detect angiogenesis with α(ν)β(3)-targeted perfluorooctylbromide nanoparticles (PFOB NP) in a U87 glioblastoma mouse model at 7 Tesla. Mice were injected intravenously with targeted or non-targeted NP and (19)F images were immediately acquired for 90 min using a PFOB-dedicated MRI sequence. Mice infused with targeted NP exhibited higher concentrations in tumors than mice of the control group, despite the presence of nonspecific signal originating from the blood. Imaging results were corroborated by histology and fluorescence imaging, suggesting specific binding of targeted NP to α(ν)β(3) integrin. Two other groups of mice were injected 24 h before imaging to allow blood clearance but no significant differences were found between both groups, probably due to a loss of specificity of PFOB NP. This is the first demonstration of the ability of (19)F MRI to detect α(ν)β(3)-integrin endothelial expression in brain tumors in vivo.

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Section: Introductionmentioning

confidence: 99%

19F molecular MR imaging for detection of brain tumor angiogenesis: in vivo validation using targeted PFOB nanoparticles

et al. 2012

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“…For example, tumor angiogenesis may be qualitatively assessed using contrast enhanced CT imaging [61]. Various quantitative measurements may be possible as well, including vascular dimension sizing [62].…”

Section: Injectable Contrastmentioning

confidence: 99%

In vivo X-Ray Computed Tomographic Imaging of Soft Tissue with Native, Intravenous, or Oral Contrast

Wathen

Foje

Avermaete

et al. 2013

Sensors

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X-ray Computed Tomography (CT) is one of the most commonly utilized anatomical imaging modalities for both research and clinical purposes. CT combines high-resolution, three-dimensional data with relatively fast acquisition to provide a solid platform for non-invasive human or specimen imaging. The primary limitation of CT is its inability to distinguish many soft tissues based on native contrast. While bone has high contrast within a CT image due to its material density from calcium phosphate, soft tissue is less dense and many are homogenous in density. This presents a challenge in distinguishing one type of soft tissue from another. A couple exceptions include the lungs as well as fat, both of which have unique densities owing to the presence of air or bulk hydrocarbons, respectively. In order to facilitate X-ray CT imaging of other structures, a range of contrast agents have been developed to selectively identify and visualize the anatomical properties of individual tissues. Most agents incorporate atoms like iodine, gold, or barium because of their ability to absorb X-rays, and thus impart contrast to a given organ system. Here we review the strategies available to visualize lung, fat, brain, kidney, liver, spleen, vasculature, gastrointestinal tract, and liver tissues of living mice using either innate contrast, or commercial injectable or ingestible agents with selective perfusion. Further, we demonstrate how each of these approaches will facilitate the non-invasive, longitudinal, in vivo imaging of pre-clinical disease models at each anatomical site.

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“…Micro-CT devices can be used for the characterization of bone or vascular microarchitecture (Peyrin, 2011;Burghardt et al, 2011;Missbach-Guentner et al, 2011). This method also allows the precise detection of the margins of tumors and their vascularity Missbach-Guentner et al, 2011).…”

Section: Current Applications Of Micro-ct In Biomechanics and Medicinementioning

confidence: 99%

Correlating Micro-CT Imaging with Quantitative Histology

Gregor¹,

Kochová²,

Eberlová³

et al. 2012

Injury and Skeletal Biomechanics

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Tumor blood vessel visualization

Cited by 18 publications

References 84 publications

19F molecular MR imaging for detection of brain tumor angiogenesis: in vivo validation using targeted PFOB nanoparticles

19F molecular MR imaging for detection of brain tumor angiogenesis: in vivo validation using targeted PFOB nanoparticles

In vivo X-Ray Computed Tomographic Imaging of Soft Tissue with Native, Intravenous, or Oral Contrast

Correlating Micro-CT Imaging with Quantitative Histology

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