2021
DOI: 10.1002/cti2.1252
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Tumor‐associated neutrophils (TANs) in human carcinoma‐draining lymph nodes: a novel TAN compartment

Abstract: Objectives The role of tumor‐associated neutrophils (TANs) in the nodal spread of cancer cells remains unexplored. The present study evaluates the occurrence and clinical significance of human nodal TANs. Methods The relevance, derivation, phenotype and interactions of nodal TANs were explored via a large immunohistochemical analysis of carcinoma‐draining lymph nodes, and their clinical significance was evaluated on a retrospective cohort of oral squamous cell carcinomas (OSCC). The tumor‐promoting function of… Show more

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Cited by 17 publications
(14 citation statements)
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“…For example, dense populations of CD66b-positive, tumor-associated neutrophils have been identified in head and neck squamous cell carcinomas, gastric and pancreatic adenocarcinomas, and transitional bladder cancer. 11 Interestingly, Wu et al assessed the localization of neutrophils in cervical cancer patients and found that the highest neutrophil density was in the peritumoral area, which is consistent with our result. 12 Furthermore, Carus et al reported that in cervical cancer patients peritumoral areas have higher median densities of CD66bpositive neutrophils than tumoral or stroma areas.…”
Section: Discussionsupporting
confidence: 91%
“…For example, dense populations of CD66b-positive, tumor-associated neutrophils have been identified in head and neck squamous cell carcinomas, gastric and pancreatic adenocarcinomas, and transitional bladder cancer. 11 Interestingly, Wu et al assessed the localization of neutrophils in cervical cancer patients and found that the highest neutrophil density was in the peritumoral area, which is consistent with our result. 12 Furthermore, Carus et al reported that in cervical cancer patients peritumoral areas have higher median densities of CD66bpositive neutrophils than tumoral or stroma areas.…”
Section: Discussionsupporting
confidence: 91%
“…We believe that our contrasting results could be due to the different methods that were used to assess neutrophil migration (i.e., Boyden chamber vs. under-agarose migration assay), as well as due to the different secretions of chemokines and soluble factors in the tumor media used in the studies (i.e., primary tumor vs. metastatic cancer cells-conditioned media). It should be noted that TANs have been shown to be present in the intra and peri-tumoral regions of the primary tumor [49,50], around the metastatic lesions and in the pre-metastatic niches [26], as well as in tumor-draining lymph nodes [51]. Hence, although displaying similar migratory abilities towards tumorrelated chemokines (Figure 2), NDN and LDN could be attracted to different tumor compartments, resulting in a differential infiltration of neutrophils' subpopulations to the diverse tumor areas.…”
Section: Discussionmentioning
confidence: 99%
“…Patients were regularly followed up with clinical examinations and neck MRI or CT every 3–6 months. Preliminary clinical and oncological findings are reported in our previous works [ 26 , 27 ]. Last follow-up was updated until September 2020.…”
Section: Methodsmentioning
confidence: 85%