Tumor-Associated Macrophages: Key Players in Triple-Negative Breast Cancer

Qiu, Xia; Zhao, Tianjiao; Luo, Ran; Qiu, Ran; Li, Zhaoming

doi:10.3389/fonc.2022.772615

Cited by 16 publications

(19 citation statements)

References 133 publications

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“…From the results, the encapsulation of nanoparticles and laser intervention improved the efficiency of drug action. In addition, M1 is characterized by the expression of a large number of induced cytokines such as TNF-α and NO, and by promoting pro-inflammatory and immune responses to exert anti-tumor activity (Gerspach et al., 2009 ; Chanmee et al., 2014 ; Qiu et al., 2022 ). The results of WB and ELISA showed that laser + CMT NPs could effectively induce macrophage typing, providing a new idea and a favorable platform for tumor immunotherapy.…”

Section: Resultsmentioning

confidence: 99%

Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles

Zou

et al. 2022

Drug Delivery

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Retinoblastoma (Rb) represents 3% of all childhood malignancies and seriously endangers children's lives and quality of life. Early diagnosis and treatment can save children's vision as much as possible. Multifunctional nanoparticles have become a research hotspot in recent years and are expected to realize the integration of early diagnosis and early treatment. Therefore, we report a nanoparticle with dual-mode imaging, photothermal therapy, and immune activation: carbonized MOF nanoparticles (CM NPs) loaded with the immune polypeptide tuftsin (CMT NPs). The dual-mode imaging ability, antitumor effect, and macrophage immunity activation ability of these nanoparticles combined with laser irradiation were studied. The biosafety of CMT NPs was detected. The multifunctional magnetic nanoparticles enhanced photoacoustic (PA) and magnetic resonance (MR) imaging in vivo and in vitro , facilitating diagnosis and efficacy evaluation. The combined effect of CMT NPs and laser irradiation was recorded and verified. Through the accumulation of magnetic field nanoparticles in tumors, the photothermal conversion of nanoparticles under laser irradiation led directly to tumor apoptosis/necrosis, and the release of tuftsin induced macrophage M1-type activation, resulting in antitumor immune effects. Enhanced PA/MR imaging CMT NPs have great potential in dual-mode image-guided laser/immune cotherapy. The nanoparticles have high biosafety and have potential in cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles

Zou

et al. 2022

Drug Delivery

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“…These precursor cells within the TME can be differentiated into active macrophages (M1 type) when stimulated by a classical pathway such as lipopolysaccharide (LPS) and IFN-γ, which exerts an antitumor effect by releasing IL-1β and cytolysin A (ClyA) or type 2 macrophages (M2) that are generated by the induction of IL-10 and TFG-β and positively enhance tumorigenesis. Moreover, the gathered findings demonstrated that TAMs found in tumor settings had a tendency to develop into M2 types when they interacted with the TME [ 98 ].…”

Section: Nf-κb Recruits and Activates Immunosuppressive Cells In Bc T...mentioning

confidence: 99%

The NF-κB Transcriptional Network Is a High-Dose Vitamin C-Targetable Vulnerability in Breast Cancer

et al. 2023

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Breast cancer (BC) is the most common cancer type among women with a distinct clinical presentation, but the survival rate remains moderate despite advances in multimodal therapy. Consequently, a deeper understanding of the molecular etiology is required for the development of more effective treatments for BC. The relationship between inflammation and tumorigenesis is well established, and the activation of the pro-inflammatory transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is frequently identified in BC. Constitutive NF-κB activation is linked to cell survival, metastasis, proliferation, and hormonal, chemo-, and radiotherapy resistance. Moreover, the crosstalk between NF-κB and other transcription factors is well documented. It is reported that vitamin C plays a key role in preventing and treating a number of pathological conditions, including cancer, when administered at remarkably high doses. Indeed, vitamin C can regulate the activation of NF-κB by inhibiting specific NF-κB-dependent genes and multiple stimuli. In this review, we examine the various NF-κB impacts on BC development. We also provide some insight into how the NF-κB network may be targeted as a potential vulnerability by using natural pro-oxidant therapies such as vitamin C.

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“…These macrophages contain M1 and M2 phenotypes, while the M1 macrophages are always transformed into M2 within the BC microenvironment, and so are the monocytes [ 39 , 40 , 41 , 42 ]. Adipocytes in the breast stroma are an important source of interleukin 10 (IL-10), which also contributes to the polarization of macrophages to the M2 phenotype in BC [ 43 , 44 , 45 ]. Clinical studies have also indicated that IL-10 is an independent factor in poor prognosis in TNBC, ER-negative, or PR-negative cases [ 46 , 47 ].…”

Section: Depression Is An Important Risk Factor and Comorbidity Of Bcmentioning

confidence: 99%

Crosstalk between Depression and Breast Cancer via Hepatic Epoxide Metabolism: A Central Comorbidity Mechanism

Ganesan²,

Wu³

et al. 2022

Molecules

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Breast cancer (BC) is a serious global challenge, and depression is one of the risk factors and comorbidities of BC. Recently, the research on the comorbidity of BC and depression has focused on the dysfunction of the hypothalamic–pituitary–adrenal axis and the persistent stimulation of the inflammatory response. However, the further mechanisms for comorbidity remain unclear. Epoxide metabolism has been shown to have a regulatory function in the comorbid mechanism with scattered reports. Hence, this article reviews the role of epoxide metabolism in depression and BC. The comprehensive review discloses the imbalance in epoxide metabolism and its downstream effect shared by BC and depression, including overexpression of inflammation, upregulation of toxic diols, and disturbed lipid metabolism. These downstream effects are mainly involved in the construction of the breast malignancy microenvironment through liver regulation. This finding provides new clues on the mechanism of BC and depression comorbidity, suggesting in particular a potential relationship between the liver and BC, and provides potential evidence of comorbidity for subsequent studies on the pathological mechanism.

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Tumor-Associated Macrophages: Key Players in Triple-Negative Breast Cancer

Cited by 16 publications

References 133 publications

Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles

Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles

The NF-κB Transcriptional Network Is a High-Dose Vitamin C-Targetable Vulnerability in Breast Cancer

Crosstalk between Depression and Breast Cancer via Hepatic Epoxide Metabolism: A Central Comorbidity Mechanism

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