Tumor-associated macrophages in human breast cancer parenchyma negatively correlate with lymphatic metastasis after neoadjuvant chemotherapy

Mitrofanova, Inna; Zavyalova, М. V.; Телегина, Н. С.; Buldakov, Mikhail A.; Riabov, Vladimir; Чердынцева, Н. В.; Kzhyshkowska, Julia

doi:10.1016/j.imbio.2016.08.001

Cited by 32 publications

(24 citation statements)

References 42 publications

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“…Quantitative digital analysis is likely to play an important role in this evolving field. Digital pathology can also be used to profile the immune cell infiltration in breast cancer and assess counts and densities with the aid of a variety of currently available software for image analysis such as UTH-SCSA ImageTool [37], ImageJ [41], automated quantita-Pathobiology 2020;87:61-74 DOI: 10.1159/000504055 tive (AQUA) immunofluorescence multiplex analysis [36], and Aperio ImageScope [56]. Recently, we used Inform v2.2.1 software in the analysis of multiplex immunofluorescence stained breast cancer tissue to evaluate immune cell phenotypes in both the intratumoural and stromal areas of the tumour microenvironment in core biopsies of IBC following NACT [78] (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…High CD68+ TIM infiltration has been associated with worse DFS and OS in breast cancer patients following neoadjuvant taxane and anthracycline (+ trastuzumab) administration to patients with HER2 overexpression [41]. CD68+ TIMs located within parenchymal tissues correlated negatively with lymphatic metastasis following neoadjuvant cyclophosphamide methotrexate fluorouracil (CMF) or fluorouracil, adriamycin, and cytoxan (FAC) [56]. A trial involving 108 breast cancer patients evaluated the effect of the addition of capecitabine to docetaxel preceded by adriamycin and cyclophosphamide in a neoadjuvant setting [57].…”

Section: Tims and Response To Neoadjuvant Chemotherapymentioning

confidence: 99%

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The Immune Microenvironment in Breast Carcinoma: Predictive and Prognostic Role in the Neoadjuvant Setting

2019

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The immune system is responsible for the maintenance of tissue homeostasis by initiating inflammatory reactions that involve the activation of innate and adaptive immune cells.• In cancer, immune responses that aim to eliminate the tumour are elicited. However, the neoplastic cells may escape the immune control through immune-editing which depends on both tumour and immune cell interactions. • New therapies have the potential to reactivate the immune response against cancer, e.g., in melanomas and lung cancer, and this is associated with improved outcomes. Novel Insights• Immune cell subpopulations, especially tumour-infiltrating lymphocytes (TILs) in the breast carcinoma microenvironment, can influence the tumour response to various neoadjuvant chemotherapy regimens, particularly in triple-negative and HER2-positive breast cancers. • Recognition of TIL subtypes and locations in relation to tumour cells in breast carcinoma are promising for the development of more effective options of targeted therapy. • The International TILs Working Group recommends the assessment of TILs on H&E sections. StromalTILs should be analysed excluding necrotic and crushed areas. Immunohistochemical and digital assessments of TILs are currently limited to the research setting. AbstractThe prognostic value of the immune cell infiltrate in the breast carcinoma microenvironment is still uncertain. We reviewed published articles analysing the infiltration of inflammatory cells in the microenvironment of breast carcinoma. Data revealed the importance of infiltration of these immune cells in the prognosis of breast carcinoma, particularly the triple-negative and HER2-positive phenotypes. Tumourinfiltrating lymphocytes and their subtypes play a fundamental role in predicting the pathological complete response (pCR) to neoadjuvant chemotherapy. More research aiming to dissect a complex network of communication between cancer cells and other cellular components of the tumour microenvironment is necessary to develop more effective therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Section: Tims and Response To Neoadjuvant Chemotherapymentioning

confidence: 99%

The Immune Microenvironment in Breast Carcinoma: Predictive and Prognostic Role in the Neoadjuvant Setting

2019

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“…Рецептор CD68 присущ практически всем популяциям макрофагов, участвует в фагоцитарной активности тканевых макрофагов, во внутриклеточном лизосомальном метаболизме, внеклеточных взаимодействиях «клетка -клетка» и «клетка -патоген», связывается с лектинами и селектинами, что позволяет макрофагу оставаться в определенном участке ткани [27,32,71,72]. Молекула стабилина ýкспрессируется на альтернативно активированных макрофагах М2, осуществляет клиренс, участвует в ангиогенезе, хоминге лимфоцитов, адгезии клеток [37,71,72].…”

Section: макрофаги и гетерогенность микроокруженияunclassified

“…Однако в участках с грубоволокнистой стромой как CD68 + , так и стабилин-1-позитивные макрофаги положительно коррелируют с количеством лимфатических узлов, вовлеченных в метастазирование Содержание CD68-позитивных макрофагов в грубоволокнистой строме коррелировало с ýффективностью НАХТ. Отмечено, что увеличение количества CD68 + ОAM в протоковых структурах оказывает протективный ýффект в отношении лимфогенного метастазирования [71,72]. Все ýти данные указывают на то, что функция ОАМ у больных после предоперационной терапии зависит от места их локализации и соответственно влияния локального микроокружения, которое играет существенную роль в направлении поляризации макрофагов в проопухолевый или противоопухолевый фенотип [72].…”

Section: макрофаги и гетерогенность микроокруженияunclassified

Macrophages and tumor progression: on the way to macrophage-specific therapy

Чердынцева¹,

Mitrofanova²,

Buldakov³

et al. 2017

Bûll. sib. med.

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“…M2 macrophage show immunosuppressive functions including scavenging potentials and promote angiogenesis and tissue repair (117). Recent studies suggests that macrophages play a key role in regulating the metastatic potential of cancer cells (118,119).…”

Section: Tumor-associated Macrophagesmentioning

confidence: 99%

Staging and tumor biological mechanisms of lymph node metastasis in invasive urinary bladder cancer

Aljabery¹

2017

Linköping University Medical Dissertations

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Aim: To study the possibility of detecting lymph node metastasis in locally advanced urinary bladder cancer (UBC) treated with radical cystectomy (RC) by using preoperative positron emission tomography/computed tomography (PET/CT) and peroperative sentinel node biopsy (SNB) technique. We also investigate the clinical significance of macrophage traits expression by cancer cells, M2-macrophage infiltration (MI) in tumor stroma and the immunohistochemical expression of biomarkers in cancer cells in relation to clinico-pathologic data. Patients and Methods:We studied prospectively 122 patients with UBC, pathological stage pT1-pT4 treated with RC and pelvic lymph node dissection (PLND) during [2005][2006][2007][2008][2009][2010][2011] at the Department of Urology, Linköping University Hospital. In the first study, we compared the results of preoperative PET/CT and conventional CT with the findings of postoperative histopathological evaluation of lymph nodes (LNs). In the second study we investigated the value of SNB technique for detecting pathological LNs during RC in patients with UBC. We also examined the significance of the primary tumor location in the bladder in predicting the site of LN metastases, and the prognostic significance of lympho-vascular invasion (LVI) and lymph node metastasis density (LNMD) on survival. In the third study, we investigate the clinical significance of macrophage infiltration (MI) in tumor stroma and macrophage-traits expression by tumor cells. In the fourth study, we investigate the cell cycle suppression pro-

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Tumor-associated macrophages in human breast cancer parenchyma negatively correlate with lymphatic metastasis after neoadjuvant chemotherapy

Cited by 32 publications

References 42 publications

The Immune Microenvironment in Breast Carcinoma: Predictive and Prognostic Role in the Neoadjuvant Setting

The Immune Microenvironment in Breast Carcinoma: Predictive and Prognostic Role in the Neoadjuvant Setting

Macrophages and tumor progression: on the way to macrophage-specific therapy

Staging and tumor biological mechanisms of lymph node metastasis in invasive urinary bladder cancer

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