Tumor‐associated genetic amplifications impact extracellular vesicle miRNA cargo and their recruitment of nerves in head and neck cancer
Anthony C. Restaino,
Austin Walz,
Sarah M. Barclay
et al.
Abstract:Cancer neuroscience is an emerging field of cancer biology focused on defining the interactions and relationships between the nervous system, developing malignancies, and their environments. Our previous work demonstrates that small extracellular vesicles (sEVs) released by head and neck squamous cell carcinomas (HNSCCs) recruit loco‐regional nerves to the tumor. sEVs contain a diverse collection of biological cargo, including microRNAs (miRNAs). Here, we asked whether two genes commonly amplified in HNSCC, CC… Show more
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