Tumor-associated gastroparesis: Correction with metoclopramide

Shivshanker, Krishnamurthy; Bennett, Roland W.; Haynie, Thomas P.

doi:10.1016/0002-9610(83)90067-3

Cited by 58 publications

(17 citation statements)

References 18 publications

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“…In addition, it may even prolong length of hospital stay and increase the patient's emotional and financial stress. While a negative gastric emptying study is highly unlikely in this subset of patients with classic gastric stasis symptoms [1,9], a positive gastric emptying study still necessitates an upper GI series and an upper endoscopy to evaluate mucosal disease and mechanical obstruction as a cause of gastric stasis in this patient population. Therefore, we do not routinely use scintigraphy in the management of PCAG.…”

Section: Diagnosis Of Pcagmentioning

confidence: 97%

“…Associated symptoms of early satiety, postprandial fullness, nausea, and vomiting can cause serious feeding disorder, which in turn may necessitate cumbersome enteric or parenteral nutritional support, delay initiation of chemotherapy, and extend length of hospital stay [1]. Little is known about this condition and optimal therapy is yet to be defined.…”

Section: Introductionmentioning

confidence: 97%

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Diagnostic and Therapeutic Approach to Pancreatic Cancer-Associated Gastroparesis

Leung¹,

Silverman²

2008

Dig Dis Sci

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Section: Diagnosis Of Pcagmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Diagnostic and Therapeutic Approach to Pancreatic Cancer-Associated Gastroparesis

Leung¹,

Silverman²

2008

Dig Dis Sci

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“…12 Barkin et al demonstrated that 60% of their study population with pancreatic carcinoma had delayed solid-phase gastric emptying. This abnormality of emptying did not correlate with the location of the tumor or the presence of hyperbilirubinemia.…”

Section: Discussionmentioning

confidence: 99%

Gastroparesis in carcinoma gallbladder: a scintigraphic study

P¹,

Eakanathan²,

Ravishankar³

2018

Int Surg J

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Background: Gastroparesis is characterized by delayed gastric emptying in the absence of mechanical gastric outlet obstruction. There is strong association of gastroparesis with carcinoma gallbladder. The aim of the study was to find out the incidence of delayed gastric emptying in carcinoma gallbladder and its correlation with symptoms of stasis and stage of the disease.Methods: Patients diagnosed with carcinoma gallbladder and their matched controls were included in this study. Patients with mechanical gastric outlet obstruction were excluded. All patients underwent contrast enhanced computer tomography scan and radio labeled (Technitium 99) solid meal Scintigraphy study. Normal gastric emptying time was calculated from control group as Mean +2SD.Results: 30 patients were matched with 20 controls after obtaining informed consent. Upper limit of gastric emptying time is 55.09 minutes. Adenocarcinoma was the commonest histological subtype (50%), abdominal pain was the commonest symptom (86.7%) and hepatomegaly was the commonest sign (46.7%), GETt1/2 for patients was 66.72±26.52 minutes while it was 40.53±7.28 minutes in controls (p <0.05). Gastroparesis increased with advancing stage of carcinoma gallbladder (p <0.05). Symptoms of gastric stasis were seen only in 15.6% of patients.Conclusions: Patients with carcinoma gallbladder can have gastroparesis without obvious symptoms of delayed gastric emptying. This delay in gastric emptying can be documented reliably using solid meal scintigraphic study even in patients without symptoms of gastroparesis. The pathophysiology of gastroparesis needs further study. It may be prudent to remember that while performing palliative bypass surgery for gastric outflow obstruction, that in patients with carcinoma gallbladder, the gastrojejunostomy may not function as expected due to delayed gastric emptying.

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“…Most cancer patients with severe early satiety have delayed upper gas- Table 2 Analysis of the relationship between the prevalence and severity of anorexia with early satiety Anorexia (N=200) [11] Anorexia (N=828) [4] Early trointestinal transit [39,40]. Prokinetics remain the treatment of choice, but many fail to respond or develop side effects [38][39][40][41].…”

Section: Gastric Dysmotilitymentioning

confidence: 99%

Early satiety in cancer patients: a common and important but underrecognized symptom

Davis

Walsh

Lagman

et al. 2006

Support Care Cancer

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Prokinetic medications, such as metoclopramide are used to treat early satiety. However, other medications which influence gastric accommodation such as clonidine, sumatriptan, or sildenafil, or diminish enteric afferent output such as kappa opioid receptor agonists, may favorably influence early satiety and should be subject to future research. Translational research is needed to understand the relationship of early satiety to gastric motility and accommodation.

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Tumor-associated gastroparesis: Correction with metoclopramide

Cited by 58 publications

References 18 publications

Diagnostic and Therapeutic Approach to Pancreatic Cancer-Associated Gastroparesis

Diagnostic and Therapeutic Approach to Pancreatic Cancer-Associated Gastroparesis

Gastroparesis in carcinoma gallbladder: a scintigraphic study

Early satiety in cancer patients: a common and important but underrecognized symptom

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