Tumor-associated bacteria capable of producing a human choriogonadotropin-like substance

Backus, B T; Affronti, Lewis F.

doi:10.1128/iai.32.3.1211-1215.1981

Cited by 20 publications

(5 citation statements)

References 17 publications

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“…Our immunocytochemical studies showed that the expression of the hCG-like material appeared to be a strain, not a species, characteristic. Moreover, the synthesis of the hCG-like material occurs in bacterial species belonging to the indigenous flora of humans (2,5,7). Of the limited number of bacteria studied, several expressing the hCG-like antigen are coagulase-negative staphylococci.…”

mentioning

confidence: 99%

Expression of human choriogonadotropin-like material in coagulase-negative Staphylococcus species

Acevedo¹,

Campbell-Acevedo²,

Kloos³

1985

Infect Immun

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We identified 101 coagulase-negative Staphylococcus strains obtained from different laboratories, the American Type Culture Collection, and our collection, isolated from 23 patients with overt cancer and 34 normal individuals through Kloos and Schleifer conventional methods and the Staph-Ident staphylococcal system (Analytab Products, Plainview, N.Y.). In 40 strains, identity was further verified by DNA-DNA hybridization techniques. Identification revealed 39 S. epidermidis, 22 S. hominis, 8 S. haemolyticus, 9 S. capitis, 5 S. warneri, 5 S. cohnii, 8 S. saprophyticus, and 5 S. xylosus strains, all resident species found in humans. All bacteria were tested for the expression of human choriogonadotropin (hCG)-like material by the indirect fluorescein and peroxidase immunocytochemical labeling techniques by using specific antisera to the whole hormone, to its a and fi subunits, to the hCGji COOH-terminal peptide, and to a monoclonal antibody to the hCG,. The results demonstrated that (i) the isolates from cancer patients were not unique bacteria, as has been postulated by others; (ii) the expression of immunoreactive hCG-like material is a strain, not a species, characteristic; (iii) not every bacterial strain isolated from a cancer patient is able to express the material; (iv) hCG-producing bacteria do not necessarily indicate the presence of active disease; (v) 20% of the strains that we studied revealed a clonal variation of the expression of hCG-like material or its subunits or both as well as a variable expression of a single hCG epitope, an observation similar to that described for malignant cells; and (vi) a specific antiserum to the whole hormone with a high affinity and high sensitivity for immunocytochemistry can be a reliable reagent for screening purposes.

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mentioning

confidence: 99%

Expression of human choriogonadotropin-like material in coagulase-negative Staphylococcus species

Acevedo¹,

Campbell-Acevedo²,

Kloos³

1985

Infect Immun

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“…Some species of Streptococcus, and of Candida express mRNAs and proteins that resemble transcripts and proteins of CG. Some of the microbe-derived peptides have been shown to produce as well as secrete gonadotropin-like peptides ( 41 , 46 – 49 , 51 – 54 , 60 – 69 ).…”

Section: Gonadotropin From Microbesmentioning

confidence: 99%

“…In the 1970s, several anaerobic and aerobic bacteria isolated from patients with a range of malignant tumors (including colon, ovary, breast and lymph node) were found to release hCG-like material when assayed for the β-subunit of hCG ( 51 , 54 ). hCG-like substances were reported in cancer patients.…”

Section: Gonadotropin From Microbesmentioning

confidence: 99%

“…It mimics LH actions in the menstrual cycle (50), but the specific function of pituitary hCG is not well understood (48). Multiple primary malignant cells such as those from colon cancer, ovarian cancer, and breast cancer also secrete hCG (46,(51)(52)(53)(54). This is considered to be a sign of poor prognosis, possibly because the free b-subunits prevent apoptosis of malignant cells, thereby enhancing the malignant cell growth (50).…”

Section: Cells Producing Hcgmentioning

confidence: 99%

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Human Chorionic Gonadotropin and Related Peptides: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

et al. 2021

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Sepsis continues to be a major cause of morbidity, mortality, and post-recovery disability in patients with a wide range of non-infectious and infectious inflammatory disorders, including COVID-19. The clinical onset of sepsis is often marked by the explosive release into the extracellular fluids of a multiplicity of host-derived cytokines and other pro-inflammatory hormone-like messengers from endogenous sources (“cytokine storm”). In patients with sepsis, therapies to counter the pro-inflammatory torrent, even when administered early, typically fall short. The major focus of our proposed essay is to promote pre-clinical studies with hCG (human chorionic gonadotropin) as a potential anti-inflammatory therapy for sepsis.

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“…After reviewing the papers of Acevedo and Cure I have formed the opinion that that the presence of hCG on tumor cell surfaces will increase the negative electrical charge of cancer cells • It is well recognized that cancer cells can produce this hormone, but certain types of tumor-associated bacteria also produce this hormone (Backus and Affronti, 1981). When Virginia Livingston Wheeler reported this same finding back in the early 1970's (Livingston-Wheeler and Livingston, 1974) her findings were dismissed and she was labeled a quack.…”

Section: Biologically Closed Electric Circuitsmentioning

confidence: 99%

Cancer: The ultimate plan

Hague¹

2019

Gen Med Open

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Introduction 2. Electricity, charge carriers and electrical properties of cells. 3. Cellular electrical properties and electromagnetic fields (EMF). 4. Attunement. 5. More details about the electrical roles of membranes and mitochondria. 6. What structures are involved in cancerous transformation? 7. Electronic roles of the cell membrane and the electrical charge of cell surface coats. 8. Cells actually have a number of discrete electrical zones. 9. The electrical properties of cancer cells part 1. 10. The electrical properties of cancer cells part 2. 11. Anatomical concepts • The intravascular space and its components • The cell membrane covering of cells and the attached glycocalyx: Chemical and anatomical roles of the cell membrane. • The extracellular space and the components of the extracellular matrix (ECM) connect to the cytoskeleton of the cells: The electronic functions of the cells and the ECM are involved in healing and tissue regeneration. • The ECM-glycocalyx-membrane interface • The intracellular space 12. Signaling mechanisms may be either chemically or resonantly mediated. 13. Resonance communication mechanisms. 14. The Bioelectrical control system. 15. Electrical properties of the ECM 16. Pathology of the ECM. 17. Mineral and water abnormalities in cancerous and injured tissues: sodium, potassium, magnesium and calcium: their effect on cell membrane potential. 18. Tumor cell differentiation, tumor hypoxia and low cellular pH can affect: gene expression, genetic stability, genetic repair, protein structures, protein activity, intracellular mineral concentrations, and types of metabolic pathways used for energy production. 19. Tumor cells express several adaptations in order to sustain their sugar addiction and metabolic strategies to address this issue. 20. Tumor acidification versus tumor alkalization. 21. The pH of the intracellular and extracellular compartments will also affect the intracellular potassium concentration. 22. Tumor cell coats contain human chorionic gonadotropin and sialic acid as well as negatively charged residues of RNA, which give tumor cells a strong negative charge on their cell surface. 23. Biologically Closed Electric Circuits. 24. Bacteria and viruses in cancer. 25. Treatment devices. 26. Polychromatic states and health: a unifying theory? 27. Treatment Section: Topics to be covered on the electrical properties of cancer cells pH changes Mineral changes Structural membrane changes Membrane potential changes Extracellular matrix changes Protein changes Gene changes Sialic acid-tumor coats-negative charge Sialic acid in viral coats and role of drugs, blood electricfication, nutrients to change infectivity

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Tumor-associated bacteria capable of producing a human choriogonadotropin-like substance

Cited by 20 publications

References 17 publications

Expression of human choriogonadotropin-like material in coagulase-negative Staphylococcus species

Expression of human choriogonadotropin-like material in coagulase-negative Staphylococcus species

Human Chorionic Gonadotropin and Related Peptides: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

Cancer: The ultimate plan

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