Tumor Angiogenesis

Becker, Jürgen C.; and, Jörg Wilting; Schweigerer, Lothar

doi:10.1002/9783527619665.ch43

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2021

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“…Understanding the mechanism of activators and inhibitors functioning in angiogenesis process is very important. 14 15 Deregulation of the balance between above-mentioned factors causes pathologic conditions such as cancer development. 16 17 This hypothesis for the first time was described by Folkman.…”

Section: Introductionmentioning

confidence: 99%

The role of pro- and antiangiogenic factors in angiogenesis process by Raman spectroscopy

Monika

Halina

2021

Preprint

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Raman spectroscopy and Raman imaging are powerful techniques to monitor biochemical composition around blood vessel. The aim of this study was to understand the role of pro- and antiangiogenic factors in angiogenesis process. Raman imaging and Raman single spectrum measurements allow the diagnosis of cancer biochemical changes in blood vessel based on several biomarkers simultaneously. We have demonstrated that Raman imaging combined with statistical methods are useful to monitoring pro- and antiangiogenic factors responsible for angiogenesis process. In this paper Raman markers of proangiogenic and antiangiogenic factors were identified based on their vibrational signatures. Obtained results can help understand how growing tumor create its vascular system.

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