Tumor Angiogenesis as a Prognostic Assay for Invasive Ductal Breast Carcinoma

Axelsson, Kristian F; Ljung, Britt Marie; Moore, Dan H.; Thor, Ann D.; Chew, Karen; Edgerton, Susan M.; Smith, Helene S.; Mayall, Brian H.

doi:10.1093/jnci/87.13.997

Cited by 209 publications

(121 citation statements)

References 5 publications

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“…Other studies that did not show an association between MVD and outcome include those by Axelsson et al and several others in which MVD did not predict metastasis-free survival or overall survival in patients with invasive breast carcinoma [21][22][23]. Leedy et al and Rutgers et al also found that MVD was not useful in determining outcome in patients with squamous cell carcinoma of the tongue or cervix, respectively [24,25].…”

Section: Discussionmentioning

confidence: 96%

Lack of Correlation Between Microvascular Density and Pathological Features and Outcomes in Sinonasal and Oral Mucosal Melanomas

Kerr

Wang

Lewis³

et al. 2011

Head and Neck Pathol

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Unlike its cutaneous counterpart, prognostic markers for primary mucosal malignant melanoma have not been well elucidated. It has been recently demonstrated that microvascular density (MVD) in cutaneous malignant melanoma has a significant negative correlation with survival; however, this has not been well-studied in mucosal malignant melanoma of the head and neck. This study explores the potential association between MVD, various histological parameters, and the outcome of a series of sinonasal and oral mucosal melanomas. Nineteen such cases were immunostained with CD31 and the MVD was calculated by using Bioquant Image Analysis Software (R and M Biometrics, Nashville, TN). These cases included 16 sinonasal and 3 oral cavity tumors. The 1, 2, 3, 4 and 5 years overall survival rates were 75, 57, 61, 46 and 46%, respectively. The MVD of the tumors ranged from 25.7 to 732 vessels/mm 2 (mean 142.8 vessels/mm 2 ; median 84.7 vessels/mm 2 ). There was no significant correlation between the MVD and the different clinicopathological features seen within the tumors. There was also no correlation between the MVD and relapse free and overall survival. The results of this study suggest that MVD does not correlate with outcome in mucosal melanoma of the head and neck as seen in cutaneous melanomas. Further larger studies are needed to identify predictive and prognostic markers in such melanomas.

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Section: Discussionmentioning

confidence: 96%

Lack of Correlation Between Microvascular Density and Pathological Features and Outcomes in Sinonasal and Oral Mucosal Melanomas

Kerr

Wang

Lewis³

et al. 2011

Head and Neck Pathol

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“…The initial observation of Weidner et al (1991) that high vascular density in the primary tumour may promote metastasis in breast carcinoma was not confirmed in two recent, extensive studies. Axelsson et al (1995) analysed tumour specimens from 220 patients with breast carcinoma and found no correlation between the vascular density of the primary tumour and metastasis-free survival or overall survival. Similarly, Goulding et al (1995) examined specimens from the primary tumour of 165 breast cancer patients and found no correlation between tumour vascularity and incidence of distant metastases or overall survival probability.…”

Section: Discussionmentioning

confidence: 99%

Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix

Sundfør

Lyng²,

Rofstad³

1998

Br J Cancer

169

106

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Summary Some clinical studies involving several histological types of cancer have suggested that high vascular density in the primary tumour promotes metastasis. Other studies have suggested that a high incidence of metastases is associated with low oxygen tension in the primary tumour. The purpose of the study reported here was to search for correlations between incidence of metastases and oxygen tension or vascular density in the same population of patients. Thirty-eight consecutive patients with squamous cell carcinoma of the uterine cervix were included in a prospective study. Pelvic, iliac and retroperitoneal lymph node metastases were detected by magnetic resonance imaging at the time of initial diagnosis. Oxygen tension was measured polarographically using the Eppendorf P02 Histograph 6650. Vascular density was determined by histological examination of tumour biopsies. The primary tumours of the patients with metastases (n = 19) were more poorly oxygenated than those of the patients without metastases (n = 19). Thus, the fractions of the P02 readings resulting in values below 5 mmHg and 10 mmHg were significantly higher for the former group of patients than for the latter (P = 0.03 and 0.02 respectively). In contrast, the vascular density of the primary tumour was not significantly different for the two groups of patients. The present study suggests that a high incidence of metastases in squamous cell carcinoma of the uterine cervix is associated with poor oxygenation of the primary tumour and not with a high vascular density.

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“…i, tumours from younger patients had higher vascuthan those from older patients. However, several een unable to confirm the statistical significance of n (van Hoef et al, 1993;Axelsson et al, 1995;Bossi han and Stein, 1995). A lack of association between prognostic indicators has previously been reported endleton et al, 1996), oral carcinoma (Williams et al, neous melanoma (Busam et al, 1995).…”

Section: Analysis Of Survivalmentioning

confidence: 99%

“…This hypothesis is widely accepted, so that vascularity measured in histological sections using pan-endothelial antibodies is increasingly referred to as 'angiogenesis'. The validity of this hypothesis, however, is questioned by results of several studies that found either no association between vascularity and prognosis (Hall et al, 1992;van Hoef et al, 1993;Axelsson et al, 1995;Busam et al, 1995;Tahan and Stein, 1995;Morphopoulos et al, 1996) or highest vascularity associated with good prognosis (Kainz et al, 1995;Zatterstrom et al, 1995).…”

mentioning

confidence: 99%

Relationship between vascularity, age and survival in non-small-cell lung cancer

Chandrachud

Pendleton²,

Chisholm³

et al. 1997

Br J Cancer

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Summary Lung tumours in the elderly show reduced growth potential; impaired angiogenesis may contribute to this phenomenon. Recent studies have suggested that the angiogenic potential of a tumour may be inferred by the vascularity measured in histological sections. The purpose of this study has been to determine whether vascularity is related to age, survival or other clinical parameters in resected non-smallcell lung cancer (NSCLC). A group of 88 consecutive patients with a follow-up period of at least 5 years was selected. The group exhibited a wide age range (37-78 years) and similar survival characteristics to those of the general NSCLC population. Tumour sections were stained with a pan-endothelial antibody (vWF) and vascularity was quantitated, without knowledge of the clinical details, by three methods: highest microvascular density; average microvascular density; and average microvascular volume. The results were analysed by non-parametric statistical tests. A correlation was found between all three methods of quantitation. Vascularity was not associated with age, sex, tumour type, stage, volume, size (TNM-T) nodal status (TNM-N) or survival. However, survival time was generally longer for patients with higher vascularity, reaching borderline significance (P = 0.06) for the average microvascular density values. Higher tumour volume (P = 0.02) and stage (P = 0.05) were associated with lower survival times. Using multivariate survival analysis, tumour volume was the only factor related to survival. We conclude that vascularity is not associated with age and has no significant prognostic value in NSCLC.

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Tumor Angiogenesis as a Prognostic Assay for Invasive Ductal Breast Carcinoma

Cited by 209 publications

References 5 publications

Lack of Correlation Between Microvascular Density and Pathological Features and Outcomes in Sinonasal and Oral Mucosal Melanomas

Lack of Correlation Between Microvascular Density and Pathological Features and Outcomes in Sinonasal and Oral Mucosal Melanomas

Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix

Relationship between vascularity, age and survival in non-small-cell lung cancer

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