Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice

Peptide-based biopolymers in biomedicine and biotechnology

“…This conjugate, formed at the expression level, was used to detect the amount of tumor uptake as well as the spatial distribution of the ELP upon hyperthermia [137]. The conjugate proved especially useful, as it allows for facile monitoring of the localization and degradation of ELP1 in vivo.…”

Elastin-like polypeptides and their applications in anticancer drug delivery systems: a review

“…Biocompatibility, biodegradability and non immunogenic properties of ELPs suggest their suitability for in vivo applications (Mackay & Chilkoti, 2008). ELPs have molecular weight greater than the renal threshold and can be retained for significantly long periods of time in blood circulation, thus increasing their plasma half-lives (Liu et al, 2006;McDaniel et al, 2010). They are degradable by proteolysis which reduces their adverse side effect due to long-term accumulation in the body (Mackay & Chilkoti, 2008).…”

“…They used an efficient synthetic method for conjugating to Doxorubicin to the polypeptide thus avoiding the generally used multi-step synthesis of drug conjugation with higher cost and lower efficiency. Liu et al (2006) have synthesized a genetically engineered ELP and examined its preferential accumulation in solid tumors upon mild hyperthermia. They investigated the biodegradability, pharmacokinetics, tumor localization and tumor spatial distribution of a C 14 -labeled ELP.…”

Injectable hydrogels

“…Because they are genetically encoded, they can be made to be monodisperse, and are enzymatically degradable in vivo. Although these materials have also been investigated as thermally triggered polymer-drug conjugates, [99][100][101][102] hydrogels have also been made from these materials for injectable drug delivering matrices, primarily complexed with silk to comprise so-called silk-elastin like polypeptides or SELPs. These materials show injectability due to reduced crystallinity of the silk component by mixing with ELPs.…”