Tumeurs malignes ophtalmologiques : indications de la radiothérapie et techniques

Jardel, P.; Caujolle, Jean‐Pierre; Gastaud, Lauris; Maschi, C.; Sauerwein, W.; Thariat, Juliette

doi:10.1016/j.canrad.2015.04.008

Cited by 9 publications

(4 citation statements)

References 65 publications

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“…Conjunctival tumors and eye lid carcinomas sometimes require radiation therapy as part of their treatment regime. Intra-ocular lymphomas, conjunctival lymphomas and retinoblastomas are very rare malignant tumors of the eye and may require irradiation [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of phosphenes in irradiated patients

et al. 2017

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Anomalous visual perceptions have been reported in various diseases of the retina and visual pathways or can be experienced under specific conditions in healthy individuals. Phosphenes are perceptions of light in the absence of ambient light, occurring independently of the physiological and classical photonic stimulation of the retina. They are a frequent symptom in patients irradiated in the region of the central nervous system (CNS), head and neck and the eyes. Phosphenes have historically been attributed to complex physical phenomena such as Cherenkov radiation. While phosphenes are related to Cherenkov radiation under high energy photon/electron irradiation conditions, physical phenomena are unlikely to be responsible for light flashes at energies used for ocular proton therapy. Phosphenes may involve a direct role for ocular photoreceptors and possible interactions between cones and rods. Other mechanisms involving the retinal ganglion cells or ultraweak biophoton emission and rhodopsin bleaching after exposure to free radicals are also likely to be involved. Despite their frequency as shown in our preliminary observations, phosphenes have been underreported probably because their mechanism and impact are poorly understood. Recently, phosphenes have been used to restore the vision and whether they might predict vision loss after therapeutic irradiation is a current field of investigation. We have reviewed and also investigated here the mechanisms related to the occurrence of phosphenes in irradiated patients and especially in patients irradiated by proton therapy for ocular tumors.

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Section: Introductionmentioning

confidence: 99%

Mechanisms of phosphenes in irradiated patients

et al. 2017

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“…The six remaining cases that did not receive surgery as a treatment option showed progression of the disease [4] or stable disease [2]. …”

Section: Treatments Administeredmentioning

confidence: 99%

“…The variation in global incidence is attributed to the genetic susceptibility and environmental exposure of each patient. About 3000 children die from retinoblastoma every year in the world, with the highest incidence in Asia and Africa [1–4]. …”

Section: Introductionmentioning

confidence: 99%

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Clinical, epidemiological, and therapeutic profile of patients with a retinoblastoma diagnosis experience in the Costa Rica National Children’s Hospital Oncology Unit from January 2009 to December 2015

Lo¹,

Rodríguez²,

Monestel³

et al. 2017

ecancer

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IntroductionRetinoblastoma represents only 3% of paediatric cancers, but it is the most prevalent intraocular tumour in this population. It develops in the retina as a primitive neuroectodermal tumour that affects development during gestation. The tumour presents in two different forms depending on whether or not it expresses a genetic modification. For patients diagnosed at preschool age, 75% are unilateral non-hereditary cases. While enucleation is the preferred treatment for advanced stages of the tumour, other modalities, such as systemic and intraocular chemotherapy, radiotherapy and local treatments with thermotherapy, cryotherapy, and brachytherapy can be used to try to preserve the eye. However, applying radiation therapy treatments increases the risk of secondary tumours.ObjectiveTo analyse the results obtained from patients with a retinoblastoma diagnosis at the Costa Rica National Children’s Hospital (HNN) Oncology Unit who received external beam radiation therapy and other therapeutic modalities during the period from January 2009 to December 2015.Materials and methodsData were extracted from the patient’s medical records and entered in a data collection instrument. We then analysed the results and formulated conclusions.ResultsA total of 36 patients were evaluated. This corresponded to 45 cases or the number of eyes affected by bilateral presentation of retinoblastoma. The documented incidence was 0.83 cases per 10,000 live births and the majority were female preschool-age children. Of these, 40% presented bilaterally and 13% were of hereditary origin. Up to 78% of these cases were diagnosed with advanced stage D and stage E. All patients who received conservative treatment progressed, requiring up to four lines of treatment. Eight patients, all in the most advanced stage, received external beam radiation due to the failure of other modalities. The main adverse effects observed were radiodermatitis, facial hypoplasia and conjunctivitis. Additionally, we report the emergence of a secondary neoplasm in two patients, one post-chemotherapy and the other post-radiotherapy.ConclusionsAdvanced-stage patients who initially received conservative treatments responded more poorly than those treated more aggressively with surgery alone or with surgery combined with another treatment modality. Treatment with radiation therapy was used in 22% of the cases (8 patients) and all patients treated with radiotherapy showed some adverse effects.

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