Tumeurs frontières de l’ovaire. Recommandations pour la pratique clinique du CNGOF — Épidémiologie et facteurs de risques de récidive, modalités de surveillance et intérêt d’une chirurgie de clôture

Margueritte, François; Sallée, Camille; Lacorre, Aymeline; Gauroy, Elodie; Larouzee, Elise; Chereau, E.; Rouge, Thibault De La Motte; Koskas, Martin; Gauthier, Tristan

doi:10.1016/j.gofs.2020.01.013

Cited by 4 publications

(6 citation statements)

References 71 publications

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“…The recommended peritoneal staging included careful inspection of the peritoneum, peritoneal cytology, multiple peritoneal biopsies, omentectomy, and appendectomy in case of mucinous type tumour or macroscopically pathological appearance [35]. It was called initial complete peritoneal staging (ICPS).…”

Section: Definitions and Proceduresmentioning

confidence: 99%

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Risk Factors for Recurrence of Borderline Ovarian Tumours after Conservative Surgery and Impact on Fertility: A Multicentre Study by the Francogyn Group

Ozenne

Berti

Body

et al. 2022

JCM

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Introduction: Borderline ovarian tumours (BOT) represent 10–20% of epithelial tumours of the ovary. Although their prognosis is excellent, the recurrence rate can be as high as 30%, and recurrence in the infiltrative form accounts for 3% to 5% of recurrences. Affecting, in one third of cases, women of childbearing age, the surgical strategy with ovarian conservation is now recommended despite a significant risk of recurrence. Few studies have focused exclusively on patients who have received ovarian conservative treatment in an attempt to identify factors predictive of recurrence and the impact on fertility. The objective of this study was to identify the risk factors for recurrence of BOT after conservative treatment and the impact on fertility. Material and methods: This was a retrospective, multicentre study of women who received conservative surgery for BOT between February 1997 and September 2020. We divided the patients into two groups, the “R group” with recurrence and the “NR group” without recurrence. Results: Of 175 patients included, 35 had a recurrence (R group, 20%) and 140 had no recurrence (NR group, 80%). With a mean follow-up of 30 months (IQ 8–62.5), the overall recurrence rate was 20%. Recurrence was BOT in 17.7% (31/175) and invasive in 2.3% (4/175). The mean time to recurrence was 29.5 months (IQ 16.5–52.5). Initial complete peritoneal staging (ICPS) was performed in 42.5% of patients (n = 75). In multivariate analysis, age at diagnosis, nulliparity, advanced FIGO stage, the presence of peritoneal implants, and the presence of a micropapillary component for serous tumours were factors influencing the occurrence of recurrence. The post-surgery fertility rate was 67%. Conclusion: This multicentre study is to date one of the largest studies analysing the risk factors for recurrence of BOT after conservative surgery. Five risk factors were found: age at diagnosis, nulliparity, advanced FIGO stage, the presence of implants, and a micropapillary component. Only 25% of the patients with recurrence underwent ICPS. These results reinforce the interest of initial peritoneal staging to avoid ignoring an advanced tumour stage.

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Section: Definitions and Proceduresmentioning

confidence: 99%

“…Regarding histological data, for serous tumours, peritoneal implants were classified as non-invasive and invasive (IPI) [29,[31][32][33][34][35][36][37][38][39][40]. Because the classification of gynaecological tumours was revised in 2014, in this work, we will maintain this nomenclature of peritoneal implants [21].…”

Section: Definitions and Proceduresmentioning

confidence: 99%

Risk Factors for Recurrence of Borderline Ovarian Tumours after Conservative Surgery and Impact on Fertility: A Multicentre Study by the Francogyn Group

Ozenne

Berti

Body

et al. 2022

JCM

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show abstract

“…Conservative treatment was defined as a surgical procedure preserving the uterus and at least part of an ovary to allow subsequent fertility (16). The recommended peritoneal staging included peritoneal cytology, extensive omentum biopsy or omentectomy, multiple peritoneal biopsies, and appendectomy in the case of mucinous type tumor (11)(12)(13). This was performed during the initial surgery (Surgery 1) when the diagnosis of BOT was confirmed by extemporaneous examination.…”

Section: Definitions and Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Conservative surgery is recommended in young women who wish to preserve their fertility, regardless of the stage of the tumor (9)(10)(11)(12)(13). The challenge in the surgical management of BOT is to facilitate conservative treatment while allowing complete staging in order to limit the risk of recurrence in the invasive form (11). A number of studies have attempted to identify the risk factors for recurrence of BOTs; however, these were mainly small studies with short followup periods and not consensual histopathological definition of borderline ovarian tumors, which have led to classification bias and inconsistent results depending on the study.…”

Section: Introductionmentioning

confidence: 99%

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258. Risk factors for recurrence of borderline ovarian tumors in France: A multicenter retrospective study by the francogyn group

Sangnier

Ouldamer²,

Bendifallah³

et al. 2022

European Journal of Obstetrics & Gynecology and Reproductiv

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Tumeurs frontières de l’ovaire. Recommandations pour la pratique clinique du CNGOF – Texte court

Bourdel

Huchon

Wahab

et al. 2020

Gynécologie Obstétrique Fertilité & Sénologie

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Tumeurs frontières de l’ovaire. Recommandations pour la pratique clinique du CNGOF — Épidémiologie et facteurs de risques de récidive, modalités de surveillance et intérêt d’une chirurgie de clôture

Cited by 4 publications

References 71 publications

Risk Factors for Recurrence of Borderline Ovarian Tumours after Conservative Surgery and Impact on Fertility: A Multicentre Study by the Francogyn Group

Risk Factors for Recurrence of Borderline Ovarian Tumours after Conservative Surgery and Impact on Fertility: A Multicentre Study by the Francogyn Group

258. Risk factors for recurrence of borderline ovarian tumors in France: A multicenter retrospective study by the francogyn group

Tumeurs frontières de l’ovaire. Recommandations pour la pratique clinique du CNGOF – Texte court

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