Tumeurs fibroblastiques et myofibroblastiques de la tête et du cou

Saïji, Essia; Guillou, Louis

doi:10.1016/j.annpat.2009.09.003

Cited by 16 publications

(12 citation statements)

References 37 publications

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“…The IMTs belong to a group of myofibroblastic tumors that include many subtypes [21]. In the paranasal sinuses, the best known is nasopharyngeal angiofibroma.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Inflammatory Myofibroblastic Tumor with Anaplastic Lymphoma Kinase 1 Rearrangement: Case Study and Literature Review

Lahlou

Classe

Wassef

et al. 2016

Head and Neck Pathol

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Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal tumors initially described in the lung. About half of them exhibit expression of the ALK1 protein, generally resulting from a gene rearrangement. Paranasal sinus IMTs are extremely uncommon, and gene rearrangement of ALK1 is very rare in this localization. A 47-year-old woman presented with rapidly progressive vision loss in her left eye. Clinical and imaging work-up revealed a tumor invading the left ethmoidal and sphenoidal sinuses and extending into the nasal cavity, the orbit and the skull base. Complete tumor resection was performed using an endonasal approach. Pathological examination revealed a paranasal localization of IMT, positive for ALK1 immunostaining. FISH analysis showed an ALK1 gene rearrangement. This case illustrates the local aggressive potential for IMTs. Treatment is primarily surgical, but targeted therapies (crizotinib) might be a solution for ALK1 rearranged cases with a poor prognosis.

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“…The IMTs belong to a group of myofibroblastic tumors that include many subtypes [21]. In the paranasal sinuses, the best known is nasopharyngeal angiofibroma.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Inflammatory Myofibroblastic Tumor with Anaplastic Lymphoma Kinase 1 Rearrangement: Case Study and Literature Review

Lahlou

Classe

Wassef

et al. 2016

Head and Neck Pathol

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“…Today IMT is accepted as a distinct entity with clinical, pathological and molecular characteristics (23). Many have been associated with aggressive local or distant behaviour that has resulted in some deaths (4,24).…”

Section: Discussionmentioning

confidence: 99%

Childhood fibroblastic and myofibroblastic tumors: a multicenter documentation and review of the literature

Kaçar¹,

Paker²,

Orhan³

et al. 2012

TJPATH

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“…IMT is a neoplastic counterpart of IPT, which shows aberrant expression of ALK and its gene translocation. [ 7 8 ] However, there is still controversy over the exact classification of IMT as a benign or malignant neoplasm. [ 9 ] In most cases, IMTs behave as benign lesions; but examples of recurrence, distant metastasis, and even malignant transformation have occurred and been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, evidence for a role of Epstein-Barr and human herpes virus-8 (HHV8) viruses has been noted in some cases of IMTs. [ 8 ] Other organisms found in association with tumor include Mycobacteria, Actinomycetes, Nocardia, Mycoplasma, Escherichia coli , Klebsiella, Bacillus sphaericus , Pseudomonas, human immunodeficiency virus (HIV), and Helicobacter pylori . [ 1 ] In this particular case, there was no definite evidence of related infection or any traumatic episode.…”

Section: Discussionmentioning

confidence: 99%

“…[ 4 ] Less common extrapulmonary sites include soft tissues, mediastinum, gastrointestinal tract, pancreas, liver, spleen, lymph nodes, kidney, skin, breasts, bone, and central nervous system. [ 3 8 ] Such lesions are rarely encountered in the head and neck region and when they do, they are commonly found in the orbit; but have been reported in locations such as the oral cavity, nasal cavity, parapharyngeal space, infratemporal fossa, nasopharynx, major salivary glands, larynx, trachea, and paranasal sinuses. [ 5 6 7 12 13 ]…”

Section: Discussionmentioning

confidence: 99%

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Malignant inflammatory myofibroblastic tumor of the maxillary sinus

Salehinejad¹,

Pazouki²,

Gerayeli³

2013

J Oral Maxillofac Pathol

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Inflammatory myofibroblastic tumors (IMTs) are extremely rare neoplasms with a variable natural history and biologic behavior, ranging from completely benign to malignant tumors with fatal outcome. They have no common identifiable cause, although some authors have assumed that any inflammatory stimulus may cause these pseudotumors. They are most commonly found in the lungs. Extrapulmonary sites include abdomen, retroperitoneum and extremities. IMTs rarely affect the head and neck, but the most common subsites in this region include the orbit, larynx, mouth, tonsils, parapharyngeal space, thyroid, parotid and lacrimal glands. There are few reports of inflammatory pseudotumors in the paranasal sinuses. In the maxillary sinus, the initial presenting sign is usually a nonspecific sinonasal mass, which has been growing over a period of weeks or months. On rare occasions, IMT may exhibit malignant transformation. Herein we present a rare case of pathologically proved IMT with malignant transformation which originated in the maxillary sinus of a 29-year-old male.

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Tumeurs fibroblastiques et myofibroblastiques de la tête et du cou

Cited by 16 publications

References 37 publications

Sinonasal Inflammatory Myofibroblastic Tumor with Anaplastic Lymphoma Kinase 1 Rearrangement: Case Study and Literature Review

Sinonasal Inflammatory Myofibroblastic Tumor with Anaplastic Lymphoma Kinase 1 Rearrangement: Case Study and Literature Review

Childhood fibroblastic and myofibroblastic tumors: a multicenter documentation and review of the literature

Malignant inflammatory myofibroblastic tumor of the maxillary sinus

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