Tumeur angiomatoïde de la thyroïde : angiosarcome primitif ou variante du carcinome anaplasique ?

Njim, Leïla; Moussa, A.; Hadhri, Rym; Gassab, I.; Yahia, N.; Mahmoudi, Houda; Zakhama, A.

doi:10.1016/j.annpat.2008.06.006

Cited by 11 publications

(3 citation statements)

References 9 publications

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“…The secondary features of ATC include acute inflammation, macrophage infiltration, and osteoclast-like multinucleated giant cells. The other reported rare variants of ATC include paucicellular variant [ 2 ], angiomatoid [ 3 ], lymphoepithelioma-like, and small-cell variant.…”

Section: Discussionmentioning

confidence: 99%

“…Anaplastic thyroid carcinoma (ATC) is the rarest type of thyroid carcinoma, accounting for approximately 0.85% of all thyroid carcinoma cases [ 1 ]. Some of the rare variants of ATC that have been described are paucicellular variant [ 2 ], angiomatoid [ 3 ], lymphoepithelioma-like, and small-cell variant. However, ATC with a chondrosarcomatous component is extremely rare [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Anaplastic thyroid carcinoma with chondrosarcomatous differentiation: a case report

et al. 2020

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Background: Anaplastic thyroid carcinoma (ATC) is a rare malignant tumor. In addition to the main ATC type with classical histopathological features, the other morphological types of ATC include paucicellular variant, angiomatoid, lymphoepithelioma-like, and small-cell variant. However, an ATC variant with a chondrosarcomatous component has not been reported to date. Case presentation: Computed tomography imaging of a 63-year-old male with a 2-month history of a cervical mass revealed a 4.5-cm lesion with heterogeneous enhancement in the left thyroid lobe and two smooth and homogeneous nodules in the right thyroid lobe. The patient underwent total thyroidectomy and cervical lymph node resection. Histologically, the tumor boundary in the left lobe was clear, with a few mitotically active, spindle sarcoma-like tumor cells observed in some areas. Immunohistochemically, these spindle cells were positive for vimentin and negative for cytokeratin, paired box-8, epithelial membrane antigen, calcitonin, thyroglobulin, and thyroid transcription factor-1. In other areas, abundant cartilage matrix production and irregularly shaped lobules of cartilage, often separated by fibrous bands, were observed. The chondrocytes appeared mildly/moderately atypical and contained enlarged, hyperchromatic nucleoli. One of the two nodules in the right thyroid lobe had a clear boundary and comprised some bland spindle cells in a prominently collagenous stroma with clear boundaries. The other nodule in the right thyroid lobe was completely enclosed within a thin, fibrous capsule and exhibited normofollicular and microfollicular architecture. The patient received adjuvant radiotherapy after the surgery and was free of any local or regional recurrence or distant metastases at the 8-month follow-up evaluation. Conclusions: This unusual case of ATC with chondrosarcomatous differentiation is an important addition to the morphology spectrum of ATC types.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anaplastic thyroid carcinoma with chondrosarcomatous differentiation: a case report

et al. 2020

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“…Cytologic and histologic features that have been described in ATC include spindle cells, pleomorphic cells, tumor giant cells, epithelial/epithelioid cells, squamoid cells, squamous cells, rhabdoid cells, small cell, osteoclast giant cell-rich, angiomatoid, and paucicellular variant. 33,38,[44][45][46][47][48] The most commonly encountered patterns are spindle cell, pleomorphic, squamous, and epithelial (Fig. 2).…”

Section: Histologic Features Of Atcmentioning

confidence: 99%

Advances in Thyroid Pathology: High Grade Follicular Cell-derived Thyroid Carcinoma and Anaplastic Thyroid Carcinoma

Ghossein

2022

Advances in Anatomic Pathology

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In the upcoming World Health Organization fifth edition classification of endocrine tumors, there were several major changes related to high grade follicular-derived thyroid carcinoma (HGFCTC) and anaplastic thyroid carcinoma (ATC) based on emerging evidence about the diagnostic criteria clinical behavior, prognostic factors, and molecular signatures of these tumors. In this review, we aim to summarize the major evolutions of HGFCTC and ATC. HGFCTC is a nonanaplastic carcinoma with high grade features (High mitotic count, tumor necrosis). It is subdivided into poorly differentiated thyroid carcinoma diagnosed using the Turin proposal and differentiated high grade thyroid carcinoma. The latter is defined by the presence of the cytoarchitectutal features of well-differentiated thyroid carcinoma (eg, papillae) but harbors elevated mitotic activity and/or tumor necrosis. Poorly differentiated thyroid carcinoma is predominantly RAS-driven and associated with RAI avidity and high propensity for distant metastasis, whereas differentiated high grade thyroid carcinoma is mostly BRAFV600E-driven. ATC may show a wide range of histologic features. Carcinoma of pure squamous phenotype is associated with a high frequency of BRAF V600E mutations and is now considered as a subtype of ATC. There is a stepwise molecular progression from well-differentiated carcinoma to HGFCTC to ATC manifested by 1) early and persistent driver alteration in the MAPK pathway, particularly BRAF V600E and RAS mutations, and 2) gain of secondary aggressive molecular signatures (such as TERT promoter and TP53 mutations) when tumors progress from well-differentiated to high grade to anaplastic carcinoma.

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Poorly Differentiated Carcinoma and Anaplastic Carcinoma of the Thyroid

Maletta

Metović

Volante

et al. 2019

Thyroid FNA Cytology

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Tumeur angiomatoïde de la thyroïde : angiosarcome primitif ou variante du carcinome anaplasique ?

Cited by 11 publications

References 9 publications

Anaplastic thyroid carcinoma with chondrosarcomatous differentiation: a case report

Anaplastic thyroid carcinoma with chondrosarcomatous differentiation: a case report

Advances in Thyroid Pathology: High Grade Follicular Cell-derived Thyroid Carcinoma and Anaplastic Thyroid Carcinoma

Poorly Differentiated Carcinoma and Anaplastic Carcinoma of the Thyroid

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