Tumefactive lipedema with pseudoxanthoma elasticum‐like microscopic changes

Taylor, Nancy E.; Foster, William C.; Wick, Mark R.; Patterson, James W.

doi:10.1111/j.0303-6987.2004.00168.x

Cited by 23 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The elasticity of the skin and fascia is decreased in lipedema [132] which in Stage III may progress to abnormally clumped elastic fibers or pseudoxanthoma [133] . The skin loses its role as an abutment for the skeletal muscle venous pump and the increased compliance of the SAT results in an increase in capillary compliance [116,124] .…”

Section: Physiology Of Lipedema Satmentioning

confidence: 99%

Rare adipose disorders (RADs) masquerading as obesity

2012

View full text Add to dashboard Cite

Rare adipose disorders (RADs) including multiple symmetric lipomatosis (MSL), lipedema and Dercum's disease (DD) may be misdiagnosed as obesity. Lifestyle changes, such as reduced caloric intake and increased physical activity are standard care for obesity. Although lifestyle changes and bariatric surgery work effectively for the obesity component of RADs, these treatments do not routinely reduce the abnormal subcutaneous adipose tissue (SAT) of RADs. RAD SAT likely results from the growth of a brown stem cell population with secondary lymphatic dysfunction in MSL, or by primary vascular and lymphatic dysfunction in lipedema and DD. People with RADs do not lose SAT from caloric limitation and increased energy expenditure alone. In order to improve recognition of RADs apart from obesity, the diagnostic criteria, histology and pathophysiology of RADs are presented and contrasted to familial partial lipodystrophies, acquired partial lipodystrophies and obesity with which they may be confused. Treatment recommendations focus on evidencebased data and include lymphatic decongestive therapy, medications and supplements that support loss of RAD SAT. Associated RAD conditions including depression, anxiety and pain will improve as healthcare providers learn to identify and adopt alternative treatment regimens for the abnormal SAT component of RADs. Effective dietary and exercise regimens are needed in RAD populations to improve quality of life and construct advanced treatment regimens for future generations.

show abstract

Section: Physiology Of Lipedema Satmentioning

confidence: 99%

Rare adipose disorders (RADs) masquerading as obesity

2012

View full text Add to dashboard Cite

show abstract

“…Our patient also had horizontal and oblique mental creases; however, the creases may not be specific because the development of a horizontal mental crease is not rare in individuals with advanced age. Taylor et al 9 reported tumefactive lipedema with PXE-like microscopic changes. The patient could have either a subclinical form of PXE, perhaps predisposing to lipedema, or secondary elastic tissue changes resulting from the massive edema.…”

Section: Discussionmentioning

confidence: 99%

Localized Pseudoxanthoma Elasticum-like Changes on the Chin

Lee

Kim

2008

Ann Dermatol

View full text Add to dashboard Cite

Department of Dermatology, Ajou University School of Medicine, Suwon, KoreaPseudoxanthoma elasticum (PXE) is a rare, inherited, multisystem disorder characterized by progressive calcification and fragmentation of elastic fibers. Typically, small, yellowish papules are located on the neck and flexural areas; however, localized acquired cutaneous PXE has been proposed as a non-heritable form of the disorder. We report a patient who had normal appearing skin on the chin with an itching sensation and had PXE-like changes by skin biopsy. (Ann Dermatol (Seoul) 20(4) 250∼253, 2008)

show abstract

“…An article published in 2004 by Taylor et al showed that accumulation of mast cells in lipedema tissue contributed to increased interstitial fluid, deterioration of adipocytes and potentially elastic fiber fragmentation due to the release of elastase [55], confirming that lipedema is a connective tissue disorder. Adding to that, direct cellcell interaction between hypertrophic adipocyte and macrophages as well as secreted paracrine factors such as vascular endothelial growth factor (VEGF), a marker of angiogenesis, previously reported in the blood of women with lipedema [56] might be associated with increase in the number of blood vessels, dilation of capillaries, hypoxia, inflammation and tissue fibrosis found in lipedema patients [15,18,57].…”

Section: Adipocytes Immune Cells and Blood Vesselsmentioning

confidence: 98%

Lipedema: A Painful Adipose Tissue Disorder

Al-Ghadban¹,

Herbst²,

Bunnell³

2019

Adipose Tissue - An Update

View full text Add to dashboard Cite

Lipedema is a painful fat disease of loose connective tissue usually misdiagnosed as lifestyle-induced obesity that affects ~10% of women of European descent as well as other populations. Lipedema is characterized by symmetric enlargement of the buttocks, hips, and legs due to increased loose connective tissue; arms are also affected in 80% of patients. Lipedema loose connective tissue is characterized by hypertrophic adipocytes, inflammatory cells, and dilated leaky blood and lymphatic vessels. Altered fluid flux through the tissue causes accumulation of fluid, protein, and other constituents in the interstitium resulting in recruitment of inflammatory cells, which in turn stimulates fibrosis and results in difficulty in weight loss. Inflammation and excess interstitial substance may also activate nerve fibers instigating the painful lipedema fat tissue. More research is needed to characterize lipedema loose connective tissue structure in depth, as well as the form and function of blood and lymphatic vessels. Understanding the pathophysiology of the disease will allow healthcare providers to diagnose the disease and develop treatments.

show abstract

Tumefactive lipedema with pseudoxanthoma elasticum‐like microscopic changes

Cited by 23 publications

References 21 publications

Rare adipose disorders (RADs) masquerading as obesity

Rare adipose disorders (RADs) masquerading as obesity

Localized Pseudoxanthoma Elasticum-like Changes on the Chin

Lipedema: A Painful Adipose Tissue Disorder

Contact Info

Product

Resources

About