Tulsi (Ocimum tenuiflorum) seeds: in vitro DNA damage protection, bioactive compounds and antioxidant potential

Kaur, Pinderpal; Dhull, Sanju Bala; Sandhu, Kawaljit Singh; Salar, Raj Kumar; Purewal, Sukhvinder Singh

doi:10.1007/s11694-018-9768-6

Cited by 40 publications

(17 citation statements)

References 31 publications

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“…Tulsi (Ocimum basilicum L.) essential oil has been shown to raise the apparent telomeres length in cell culture and to downregulate the telomeric repeat binding factor 1 (TERF-1) telomere length suppressor [36]. Other authors found that bioactive compounds present in seed extracts from another Tulsi variety, i.e., Ocimum tenuiflorum L., exerted a prominent antioxidant potential and conferred DNA protection in a plasmid DNA pBR322 model [37].…”

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confidence: 99%

Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs

Sharma

Martins

2020

JCM

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confidence: 99%

Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs

Sharma

Martins

2020

JCM

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“…Condensed plant tannins from the seed extract of Marwa (Origanum majorana) were reported by Dhull and coworkers [27] to possess antioxidant properties. Kaur et al [28] reported that bioactive compounds from Tulsi (Ocimum tenuiflorum) seeds possess antioxidant activities and DNA damage protection.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Anti-Inflammatory Activities of Methanolic Leaf Extract of Bauhinia monandra in Animal Models

Okorie

Nworie

2018

IJPPE

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The leaves of Bauhinia monandra prepared as poultices are used in many Brazilian tribes and some Nigerian communities to relieve swelling and pains, arthritis, diabetes among other ailments. These folkloric claimed benefits inspired this study in which topical and systemic anti-inflammatory activities of a methanol extract of B. monandra leaves (MEBmL) was assessed in rodents. The anti-inflammatory activities of B. monandra were determined by egg albumin-induced (systemic) paw edema in rats, and xylene-induced (topical) ear edema in mice. Treatment of rats with MEBmL at different concentration (200 and 400 mg/kg) led to significant (p<0,05) reduction (31.0% and 28.0% respectively) of the egg albumin-induced paw edema. Topical application of mice ear with MEBmL (50, 100 mg/kg) also significantly (p<0.05) reduced (39.50% and 41.87% respectively) xylene-induced ear edema. Based on the findings of the study, B. monandra has a promising therapeutic potential with its anti-inflammatory activities as associated with folkloric use of the plant.

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“…Briefly, various concentrations of the extracts (0.2 -1.0 mg/ml) were suspended in 1 ml of distilled water, mixed with 250 µl of 1% potassium ferricyanide [K 3 Fe(CN) 6 ]. The mixture was incubated at 50 0 C for 20 minutes, and 250 µl of trichloroacetic acid was added.…”

Section: Ferric Ion Reducing Abilitymentioning

confidence: 99%

“…Antioxidants are substances that prevent or delay some types of damages to the cell and different types are found in different fruits [6]. They are found in high fruits or vegetable diets.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Study on Phytochemical Composition and In Vitro Radical Scavenging Activity of Ethanolic Extracts of Landolphia lanceolata and Nutraceutical-C24/7

Chibuzo

Hauwa

Zubairu

2018

IJPPE

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Abstract. This study investigated the phytochemical composition and in-vitro radical scavenging activity of ethanolic extracts of Nutraceutical-C24/7 and Landolphia lanceolata fruit. Phytochemical screening of Landolphia lanceolata fruit extract indicated the presence of phenols, flavonoids, saponins, alkaloids, terpenoids, tannins, triterpenoids and steroids while nutraceutical-C24/7 showed presence of with exception of saponins, terpenoids and triterpenoids. Some of the identified phytochemicals and vitamins concentrations quantified were higher in Landolphia lanceolata fruit extract than nutraceutical-C24/7 with statistically significant difference (p<0.05) with the former having flavonoids 0.062±0.00mg/ml, phenol 0.097±0.00mg/ml, vitamin C 206±42mg/dL, vitamin B 1 54.16±0.00mg/dL and vitamin B 2 0.11±0.00mg/dL while, Nutraceutical-C24/7 extract had flavonoid 0.117±0.00mg/ml, phenol 0.032±0.00, vitamin C 102.24±0.00mg/dL, vitamin B 1 23.36±0.00mg/dL, and vitamin B 2 0.067±0.00mg/dL. The study also showed that at higher concentration, DPPH radical, ferric ion, and hydrogen peroxide the extracts radical scavenging activity increased. The study showed that the extracts scavenging activities at different concentrations had higher percentage inhibition on DPPH radical, reducing power of ferric ion capabilities and reducing composition of hydrogen peroxide indicated that ethanolic extract of Landolphia lanceolata fruit showed statistically significant different (p<0.05) when compared with ethanolic extract of Nutraceutical-C24/7. Standard vitamin C percentage inhibition for DPPH radical compared well with that of Landolphia lanceolata fruit extract at higher concentration with no statistical significant different (p>0.05). The indigenous functional food Landolphia lanceolata fruit can be concluded to be a good antioxidant that can scavenge, inhibit and quench free radicals. This suggests that Landolphia lanceolata may be considered a good source and alternative antioxidant for developing countries like Nigeria.

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Tulsi (Ocimum tenuiflorum) seeds: in vitro DNA damage protection, bioactive compounds and antioxidant potential

Cited by 40 publications

References 31 publications

Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs

Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs

Phytochemical Screening and Anti-Inflammatory Activities of Methanolic Leaf Extract of <i>Bauhinia monandra</i> in Animal Models

Comparative Study on Phytochemical Composition and <i>In Vitro</i> Radical Scavenging Activity of Ethanolic Extracts of <i>Landolphia</i> <i>lanceolata</i> and Nutraceutical-C24/7

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