Tularemia in children

“…Early‐phase tularemia is characterized by abrupt onset of febrile illness (sustained high fever within a day or so) that can be self‐limiting and is rarely fatal with prompt medical care (Adamovicz et al., ; Dembek, ; Hepburn et al., ). Cases treated promptly with effective antibiotics typically became afebrile rapidly, for example, within 1–3 days of streptomycin treatment (Hughes, ; Martone et al., ; Overholt et al., ). For any of the forms of tularemia, systemic progression in the absence of prompt medical treatment can involve all the major organ systems, including the pulmonary system (Weinstein & Alibek, ).…”

Section: Introductionmentioning

confidence: 99%

Human Dose–Response Data for Francisella tularensis and a Dose‐ and Time‐Dependent Mathematical Model of Early‐Phase Fever Associated with Tularemia After Inhalation Exposure

McClellan

Coleman²,

Crary

et al. 2018

Risk Analysis

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Military health risk assessors, medical planners, operational planners, and defense system developers require knowledge of human responses to doses of biothreat agents to support force health protection and chemical, biological, radiological, nuclear (CBRN) defense missions. This article reviews extensive data from 118 human volunteers administered aerosols of the bacterial agent Francisella tularensis, strain Schu S4, which causes tularemia. The data set includes incidence of early-phase febrile illness following administration of well-characterized inhaled doses of F. tularensis. Supplemental data on human body temperature profiles over time available from de-identified case reports is also presented. A unified, logically consistent model of early-phase febrile illness is described as a lognormal dose-response function for febrile illness linked with a stochastic time profile of fever. Three parameters are estimated from the human data to describe the time profile: incubation period or onset time for fever; rise time of fever; and near-maximum body temperature. Inhaled dose-dependence and variability are characterized for each of the three parameters. These parameters enable a stochastic model for the response of an exposed population through incorporation of individual-by-individual variability by drawing random samples from the statistical distributions of these three parameters for each individual. This model provides risk assessors and medical decisionmakers reliable representations of the predicted health impacts of early-phase febrile illness for as long as one week after aerosol exposures of human populations to F. tularensis.

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“…Κρούσματα τής νόσου ή επιδημίαι περιεγράφησαν συχνότατα πλην τών Η. Π. Α. καΐ εις αλλάς χώρας τής Βορείου 'Αμερικής (Avery et al 1967, Assai et al 1967, Cabelli and Hodapp 1964, Hopla 1960, Hughes 1963, Miller and Bates 1969, Saliba and Harmston 1966, είς τήν Ρω-σίαν (Shmuter 1959, Borodin et al 1959, Tsareva 1959, Slupnitskaya and Marinov 1964, την Ίαπωνίαν (Sase, 1957) καΐ etc ολας σχεδόν τάς χώρας της Ευρώπης (Jusalz 1961, Kneidel 1963) πλην της 'Ισπανίας, Δα νίας, 'Αγγλίας και Όλλανδίας.…”

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Ερευνα Της Επιβραδυνομενης Υπερευαισθησιας Εναντι Της P. Tularensis Επι Ελληνικου Πληθυσμου

Μουτσοπουλοσ¹

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Tularemia in children

Cited by 10 publications

References 8 publications

Case 1-1998

Case 1-1998

Human Dose–Response Data for Francisella tularensis and a Dose‐ and Time‐Dependent Mathematical Model of Early‐Phase Fever Associated with Tularemia After Inhalation Exposure

Ερευνα Της Επιβραδυνομενης Υπερευαισθησιας Εναντι Της P. Tularensis Επι Ελληνικου Πληθυσμου

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