Background: Constipation is one of the most common diseases in children and it is also a significant healthcare burden, more than many other common childhood diseases. Massage has gained increased popularity for the management of constipation. However, there is a lack of supportive evidence on the efficacy of massage for constipation in children. This systematic review aims to collect and critically appraise all the available evidence about the efficacy and safety of massage for functional constipation (FC) in children. Methods/Design: The electronic databases of Embase, PubMed, and the Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database, Wanfang Database (Wanfang), Chinese Scientific and Journal Database (VIP) will be searched from the establishment to February 2021 for randomized controlled trials investigating massage for treatment of functional constipation in children. Papers not in English or Chinese language were excluded. Two independent reviewers will conduct studies retrieval, remove duplication, screen, extract data, evaluate quality, and analyze data by NoteExpress (Version 3.2) and RevMan (Version 5.3.5 software (the Cochrane Collaboration, Oxford, England). We will conduct the meta-analysis to synthesis the evidence for each outcome. The primary outcome included: 1) Overall response rate (according to stool frequency, time of defecation interval, stool consistency, difficult defecation, sense of incomplete evacuation, abdominal pain and bloating); 2) The mean number of bowel movements in the fourth week. Secondary outcome measures included 1) The symptom integrals; 2) Adverse events; 3) Recurrence rate. Cochrane Handbook for Systematic Reviews of Interventions will be used to assess the risk of bias, and GRADE will be used to access the confidence in cumulative evidence. The protocol followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols.Discussion: The findings of this meta-analysis will be important to clinicians and patients regarding the use of massage in childhood functional constipation.Study registration: PROSPERO registration number: CRD42021237173