Tufted hair folliculitis associated with Melkersson-Rosenthal syndrome and hidradenitis suppurativa

Güngör, Şükrü; Yüksel, Tülin; Topal, İlteriş Oğuz

doi:10.4103/0378-6323.140354

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…Multiple hairs are seen emerging from a single follicular opening (Figure 2) [13]. THF may be seen with dissecting cellulitis of the scalp, folliculitis decalvans, acne keloidalis, Melkersson-Rosenthal syndrome and hidradenitis suppurativa [16]. In some case reports it has been described that tufted folliculitis in association with medication use, specifically with cyclosporine and lapatinib [17,18].…”

Section: Tufted Hair Folliculitismentioning

confidence: 99%

Infections, Infestations and Neoplasms of the Scalp

Canpolat¹

2017

Hair and Scalp Disorders

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This chapter reviews common cutaneous infections, infestations, and neoplasms of the scalp. Infections of the scalp are subdivided into three major groups. The most seen are: (1) Bacterial: Folliculitis, folliculitis decalvans, tufted hair folliculitis and acne keloidalis nuchae. (2) Fungal: Tinea capitis, favus and kerion celsi. (3) Protozoal: Syphilitic alopecia. Pediculosis capitis is the most common worldwide infestation of the scalp. The neoplasms of the scalp are large group of different diseases due to arising different origin. In the following section, trichilemmal cyst, proliferating trichilemmal cyst, nevus sebaceous and cylindroma are discussed in detail.

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Section: Tufted Hair Folliculitismentioning

confidence: 99%

Infections, Infestations and Neoplasms of the Scalp

Canpolat¹

2017

Hair and Scalp Disorders

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“…Primary hair tufting, local trauma, tinea capitis, nevoid malformation, and Staphylococcus aureus infection have been proposed as causative pathomechanisms. 3 Typically there is no history of underlying disease or trauma on the scalp; however, secondary changes may have occurred following unrecognized trauma or repeated stimuli. Staphylococcal infections may play a notable role in inducing THF.…”

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confidence: 99%

Erythematous Plaque on the Scalp With Alopecia

Yong-fang¹,

Yao²,

Zhou³

et al. 2020

Cutis

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A 37-year-old woman presented with a 2×6-cm, firm, erythematous plaque on the parietal region of the scalp of 1 year's duration. No history of injury to the scalp was noted. The patient noticed hair loss in the affected area in the month prior to presentation. She was afebrile and otherwise asymptomatic. She denied a family history of similar scalp disorders. WHAT'S THE DIAGNOSIS? a. discoid lupus erythematosus b. dissecting cellulitis of the scalp c. follicular lichen planus d. folliculitis keloidalis nuchae e. tufted hair folliculitis

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A novel NCSTN gene mutation in a Chinese family with acne inversa

Yang

Zhang

et al. 2018

Mol Genet Genomics

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Acne inversa (AI) is a chronic inflammatory disease of hair follicles. The pathogenesis of AI remains unclear. Haploinsufficiency of genes encoding γ-secretase components is the genetic basis for a subset of familial AI. Idiopathic guttate hypomelanosis (IGH) is a leukoderma characterized by multiple porcelain-white macules. Familial AI associated with IGH has not been reported previously. Herein, we present the pathogenic variation in a Chinese Han family with AI and IGH. Peripheral blood samples were collected from 16 members of the entire family. Eighteen exons and flanking introns of the NCSTN gene were amplified by polymerase chain reaction. Two hundred unrelated healthy Chinese subjects were used as controls. Sequencing results were analysed using CodonCode Aligner Software. Seven of the 16 family members in three generations were AI patients. Six AI patients also had IGH, while the other only had AI. One had IGH without AI. All AI patients carried the mutation, c.218delC, located in exon 4 of NCSTN. The deletion mutation led to a reading frame shift and the appearance of a premature termination codon (p.P73Lfs*15), resulting in the production of truncated protein. Family members without AI did not carry this mutation, indicating that it cosegregated with the phenotype. The mutation was not detected among the controls. This mutation has not been reported in the EXaC, HGMD, and dbSNP databases. In addition, we performed whole-exome sequencing on the proband and finally screened six candidate genes, ADAMTS2, BUB1B, CRB2, FBLN1, SEC24B, and WNK1, which we further validated in effected family members, and none of them were cosegregated. In conclusion, we identified a novel deletion mutation in exon 4 of NCSTN, which may underlie the molecular pathogenesis in this AI family. However, we found no relationship between this mutation and IGH.

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Tufted hair folliculitis associated with Melkersson-Rosenthal syndrome and hidradenitis suppurativa

Cited by 4 publications

References 4 publications

Infections, Infestations and Neoplasms of the Scalp

Infections, Infestations and Neoplasms of the Scalp

Erythematous Plaque on the Scalp With Alopecia

A novel NCSTN gene mutation in a Chinese family with acne inversa

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