Tubulovillous adenoma of the colon with hyperdiploidy, double-minute chromosomes, and inversion of chromosome 1

Clonal karyotypic abnormalities in colorectal adenomas: Clues to the early genetic events in the adenoma-carcinoma sequence

“…We have previously found a deletion of l p (lp36 was the minimal common deleted seg-ment) in 5 of 7 adenomas and have argued that this is a primary change in colorectal carcinogenesis (Bardi et al, 1993~). Among cytogenetically characterized adenomas published by other groups, cases with loss of material from l p have been described by Reichmann et al (1985), Couturier-Turpin et al (1988, 1992, and Longy et al (1993). Our conclusion (Bardi et al, 1993c) that del(l)(p36) is a very early, probably the earliest, change in a subset of intestinal tumors is further supported by the detection of rearrangements in the short arm of chromosome 1 in 6 of the 17 successfully karyotyped adenomas presented here.…”

Evaluation of Metastatic Potential of Gastric Tumors by Staining for Proliferating Cell Nuclear Antigen and Chromosome 17 Numerical Aberrations

“…29,30 Previous studies reported that elimination of chromosome 17 aberrations might be important in the tumor aggressiveness of several carcinomas. [1][2][3][4][5][6][7][8][9] We have also shown that alterations of chromosome 17 might be linked with tumorigenesis and tumor progression. 9 The main purpose of this study was to further characterize cells with alterations of chromosome 17.…”

“…For example, chromosome 17 loss has been reported in one case of breast hyperplasia 6 (suggesting that some hyperplasias may be part of a progressive sequence to malignancy in breast cancer) and also in a tubulovillous adenoma of the colon. 7 In gastric lesions, numerical aberrations in chromosome 17 have been also reported in gastric intestinal metaplasia and gastric cancers, 8 suggesting that the alteration of chromosome 17 is significant in gastric carcinogenesis. We have recently demonstrated the presence of numerical aberrations in chromosome 17 at early stages during carcinogenesis and that such aberrations were associated with tumor progression in gastric cancer.…”

“…Aberrations in chromosome 17 are well characterized because they are important in tumor carcinogenesis or development. [1][2][3][4][5][6][7][8][9] Numerical aberrations in chromosome 17 might be an early event in human solid tumor. For example, chromosome 17 loss has been reported in one case of breast hyperplasia 6 (suggesting that some hyperplasias may be part of a progressive sequence to malignancy in breast cancer) and also in a tubulovillous adenoma of the colon.…”

Interphase cytogenetic studies of human hepatocellular carcinomas by fluorescentin situ hybridization

“…46 However, focal nodular hyperof six tumors. Tumors 3, 5, and 7 were almost exclusively disomic or monosomic for the three studied chro-plasia is a benign liver tumor that generally does not become malignant.…”