Tubulosquamous polyps in the vagina. Immunohistochemical comparison with ectopic prostatic tissue and Skene glands

A case of a vaginal Brenner tumor without a gland mimicking a borderline tumor: unusual morphology and diagnostic pitfalls

“… 9 Prostatic-type tissue can be found in the polyps, and glandular tissue is always positive for prostatic-specific antigen. 10 , 11 …”

“…9 Prostatic-type tissue can be found in the polyps, and glandular tissue is always positive for prostatic-specific antigen. 10,11 An important characteristic of borderline Brenner tumors of the ovary is that areas of atypia coexist with benign components, but without stromal invasion. Cytological findings that confirm a Brenner tumor as proliferative or borderline are as follows: mucinous or squamous metaplasia in the transitional epithelium, the presence of small papillary processes, complex glandular formation, and nuclear atypia, including hyperchromatic nuclei, coarse chromatin clumping, prominent nucleoli, and increased mitotic activity.…”

Uncommon Cervical Lesions: A Review and Discussion of the Differential Diagnosis

“…Prostatic-type tissue in the female genital tract is a phenomenon first described in the uterine cervix in 1997, 90 with subsequent literature expanding the clinicopathologic picture of the lesions. [91][92][93][94][95][96][97][98][99][100] The prostatic-type tissue is composed of glands identical in morphology and immunohistochemical staining to male prostatic glands, and frequently lined by basal cells (Figure 7, A). Early studies reported the presence of prostatic glands within the lamina propria of the uterine cervix, sparing the squamous epithelium, but with frequent and often extensive squamous metaplasia in the prostatic-type glands, with the potential for misdiagnosis as squamous cell carcinoma when identified deep within the stroma (Figure 7, B through D).…”

“…Most cases in these early studies were identified incidentally during evaluation of squamous intraepithelial lesions, with rare presentation as a clinically identified mass. 91 Immunohistochemically, the lesions have been reported to be reactive with prostate- specific antigen, [90][91][92][93][94][95]97,99,100 prostate-specific acid phosphatase, [90][91][92][93][94][95]97,100 androgen receptor, 99,100 NKX3.1, 98,99 and CK7. 99 High-molecular-weight CK shows positivity in the basal cell layer if present.…”

“…92,99 Similar lesions have been described in the vagina (tubulosquamous polyps) and vulva. [95][96][97][98][99] While most studies have reported only involve-ment of the lamina propria with an uninvolved squamous and endocervical glandular epithelium, a recent study 99 described prostatic-type tissue present within the squamous epithelium of the vagina and ectocervix in patients with androgen excess (most commonly, long-term testosterone therapy for gender dysphoria).…”