Tubulointerstitielle Nephritis mit Uveitis (TINU-Syndrom) - KomorbiditÃ¤t und Komplikationen bei vier Patienten

Hudde, Tobias; Heinz, Carsten; Neudorf, Ulrich; Hoeft, Sabine; Heiligenhaus, Arnd; Steuhl, Klaus‐Peter

doi:10.1055/s-2002-33583

Cited by 16 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the course of sulfasalazine treatment he had no new joint symptom. In literature, symptoms indicative of rheumatoid arthritis or sacroiliitis have been reported in the follow-up period (11,12). But, to our knowledge, this is the first report of TINU syndrome developing symmetrical synovitis with a Baker 's cyst in the follow-up period.…”

Section: Discussionmentioning

confidence: 79%

Tubulointerstitial Nephritis And Uveitis Syndrome With Symmetrical Synovitis In A Male Adolescent

et al. 2005

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 79%

Tubulointerstitial Nephritis And Uveitis Syndrome With Symmetrical Synovitis In A Male Adolescent

et al. 2005

View full text Add to dashboard Cite

“…Isolated cases of hyperthyroidism have been reported in association with tubulointerstitial nephritis and uveitis, a self-limited syndrome of unknown etiology that responds to glucocorticoids (68)(69)(70)(71). In these cases, the etiology of hyperthyroidism was not Graves' disease, but rather a destructive thyroiditis with the absence of thyroid autoimmunity, low uptake in thyroid scintigraphy, and adequate response to steroid therapy (68,69).…”

Section: Tubular Diseasementioning

confidence: 99%

Thyroid dysfunction and kidney disease

Iglesias

Díez

2009

European Journal of Endocrinology

375

352

View full text Add to dashboard Cite

Thyroid hormones (TH) are essential for an adequate growth and development of the kidney. Conversely, the kidney is not only an organ for metabolism and elimination of TH, but also a target organ of some of the iodothyronines' actions. Thyroid dysfunction causes remarkable changes in glomerular and tubular functions and electrolyte and water homeostasis. Hypothyroidism is accompanied by a decrease in glomerular filtration, hyponatremia, and an alteration of the ability for water excretion. Excessive levels of TH generate an increase in glomerular filtration rate and renal plasma flow. Renal disease, in turn, leads to significant changes in thyroid function. The association of different types of glomerulopathies with both hyper-and hypofunction of the thyroid has been reported. Less frequently, tubulointerstitial disease has been associated with functional thyroid disorders. Nephrotic syndrome is accompanied by changes in the concentrations of TH due primarily to loss of protein in the urine. Acute kidney injury and chronic kidney disease are accompanied by notable effects on the hypothalamus-pituitary-thyroid axis. The secretion of pituitary thyrotropin (TSH) is impaired in uremia. Contrary to other non-thyroidal chronic disease, in uraemic patients it is not unusual to observe the sick euthyroid syndrome with low serum triodothyronine (T 3 ) without elevation of reverse T 3 (rT 3 ). Some authors have reported associations between thyroid cancer and kidney tumors and each of these organs can develop metastases into the other. Finally, data from recent research suggest that TH, especially T 3 , can be considered as a marker for survival in patients with kidney disease.

show abstract

“…Steroids are widely used in this indication. Regional and systemic steroids may be sufficient; steroid-sparing immunosuppressives are sometimes necessary, at least temporarily (azathioprine, cyclosporine A, mycophenolate mofetil, or methotrexate) [11].…”

Section: Discussionmentioning

confidence: 99%

Tubulointerstitial nephritis and uveitis syndrome in a mother and her son

et al. 2008

View full text Add to dashboard Cite

A mother and her son, both with tubulointerstitial nephritis and uveitis syndrome (TINU) are reported. The nephritis presented itself at 13 years in the mother and at 10 years in her son. Glomerular filtration (GFR) decreased in both, and renal biopsies confirmed the diagnosis. Nephritis preceded the onset of uveitis in both. Clinical course and renal function improved quickly on oral steroids in the boy. The mother's hyperazotemia decreased spontaneously (without steroids), but not to normal range, and remained stable for 35 years of follow-up. Local steroids due to recurrences of uveitis were repeatedly needed in both. We believe this is the first report on familial occurrence of inherited TINU syndrome in two generations.

show abstract

Tubulointerstitielle Nephritis mit Uveitis (TINU-Syndrom) - KomorbiditÃ¤t und Komplikationen bei vier Patienten

Cited by 16 publications

References 8 publications

Tubulointerstitial Nephritis And Uveitis Syndrome With Symmetrical Synovitis In A Male Adolescent

Tubulointerstitial Nephritis And Uveitis Syndrome With Symmetrical Synovitis In A Male Adolescent

Thyroid dysfunction and kidney disease

Tubulointerstitial nephritis and uveitis syndrome in a mother and her son

Contact Info

Product

Resources

About