Tubulointerstitial damage and interstitial immune cell phenotypes are useful predictors for renal survival and relapse in antineutrophil cytoplasmic antibody-associated vasculitis

Bitton, Laura; Vandenbussche, C.; Wayolle, N.; Gibier, Jean‐Baptiste; Cordonnier, C.; Verine, Jérôme; Humez, Sarah; Bataille, Pierre; Lenain, Rémi; Ramdane, Nassima; Azar, Raymond; Namara, E. Mac; Hatron, Pierre‐Yves; Maurage, Claude‐Alain; Perrais, Michaël; Frimat, Marie; Vanhille, Philippe; Guilhot, François; Buob, David; Copin, Marie‐Christine; Quéméneur, T.; Gnemmi, Viviane

doi:10.1007/s40620-019-00695-y

Cited by 13 publications

(14 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Monocytes and macrophages have also been increasingly implicated in AAV pathogenesis as the actual initiators and maintainers of the vasculitic process [ 25 ]. Specifically, an alternatively activated (M2-polarized) macrophage linked to a Th2-dominant (anti-inflammatory and pro-fibrogenic) response is considered to be the prevailing phenotype in early, established and quiescent AAV lesions and is further correlated with ESRD risk in one study [ 26 , 27 ]. In keeping with this, hsa-miR-142-5p has been demonstrated to promote and maintain M2 macrophage polarization by targeting suppressor of cytokine signaling 1 (SOCS1), resulting in sustained phosphorylation and signaling via the signal transducer and activator of transcription (STAT) 6, which is considered to be an essential transcription factor in M2-related gene expression [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Renal Tissue miRNA Expression Profiles in ANCA-Associated Vasculitis—A Comparative Analysis

Bošnjak

Večerić-Haler

Boštjančič

et al. 2021

IJMS

View full text Add to dashboard Cite

Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) comprises autoimmune disease entities that cause target organ damage due to relapsing-remitting small vessel necrotizing vasculitis, and which affects various vascular beds. The pathogenesis of AAV is incompletely understood, which translates to considerable disease- and treatment-related morbidity and mortality. Recent advances have implicated microRNAs (miRNAs) in AAV; however, their accurate characterization in renal tissue is lacking. The goal of this study was to identify the intrarenal miRNA expression profile in AAV relative to healthy, non-inflammatory and inflammatory controls to identify candidate-specific miRNAs. Formalin-fixed, paraffin-embedded renal biopsy tissue samples from 85 patients were obtained. Comprehensive miRNA expression profiles were performed using panels with 752 miRNAs and revealed 17 miRNA that differentiated AAV from both controls. Identified miRNAs were annotated to characterize their involvement in pathways and to define their targets. A considerable subset of differentially expressed miRNAs was related to macrophage and lymphocyte polarization and cytokines previously deemed important in AAV pathogenesis, lending credence to the obtained results. Interestingly, several members of the miR-30 family were detected. However, a validation study of these differentially expressed miRNAs in an independent, larger sample cohort is needed to establish their potential diagnostic utility.

show abstract

Section: Discussionmentioning

confidence: 99%

Renal Tissue miRNA Expression Profiles in ANCA-Associated Vasculitis—A Comparative Analysis

Bošnjak

Večerić-Haler

Boštjančič

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Biopsies showed a median of 17 [13][14][15][16][17][18][19][20][21][22] glomeruli of which 2 [1][2][3][4][5] were globally sclerotic. The proportions of sclerotic and normal glomeruli were 14% (6-31%) and 30% (16-54%), respectively.…”

Section: Characteristics Of the Study Group At Diagnosismentioning

confidence: 99%

“…Nevertheless, hematuria and proteinuria can persist during remission, and the alteration of renal function due to the vasculitis flare is poorly evaluated by this score [16]. Very few data are available on the improvement of renal function after induction therapy for AAV [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…In this context, it seems important to establish how renal function evolves from diagnosis to remission to best evaluate expected gains in renal function and identify prognostic factors for successful early treatment. These factors may be clinical or immunological, but they are probably mainly histological [11,17,19]. The association between glomerulosclerosis, tubulointerstitial fibrosis, and long-term prognosis has been well studied [17,19].…”

Section: Introductionmentioning

confidence: 99%

“…These factors may be clinical or immunological, but they are probably mainly histological [11,17,19]. The association between glomerulosclerosis, tubulointerstitial fibrosis, and long-term prognosis has been well studied [17,19]. Less is known about the recovery potential of acute lesions [18].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Early Renal Recovery after the First Flare of Pauci-Immune Glomerulonephritis

et al. 2022

Self Cite

View full text Add to dashboard Cite

Introduction: Renal involvement is a severe manifestation of antineutrophil cytoplasmic antibody-associated vasculitis. Patients often progress to end-stage renal disease. The potential for renal recovery after the first flare has seldom been studied. Our objectives were to describe the evolution of the estimated glomerular filtration rate (eGFR) and identify factors associated with the change in the eGFR between diagnosis and the follow-up at 3 months (ΔeGFRM0–M3). Methods: This was a retrospective study over the period 2003–2018 of incident patients in the Nord-Pas-de-Calais (France). The primary outcome was the ΔeGFRM0–M3. Results: One hundred and seventy-seven patients were included. The eGFR at 3 months was significantly higher than at diagnosis (mean ± standard deviation, 40 ± 24 vs. 28 ± 26 mL/min/1.73 m2, p < 0.001), with a ΔeGFRM0–M3 of 12 ± 19 mL/min/1.73 m2. The eGFR at 12 months was higher than at 3 months (44 ± 13 vs. 40 ± 24 mL/min/1.73 m2, p = 0.003). The factors significantly associated with the ΔeGFRM0–M3 in multivariate analysis were the percentage of cellular crescents and neurological involvement. The mean increase in the eGFR was 2.90 ± 0.06 mL/min/1.73 m2 for every 10-point gain in the percentage of cellular crescents. Conclusions: Early renal recovery after the first flare of pauci-immune glomerulonephritis occurred mainly in the first 3 months of treatment. The percentage of cellular crescents was the main independent predictor of early renal recovery.

show abstract

The correlation of interstitial change with renal prognosis in patients with myeloperoxidase-ANCA-associated glomerulonephritis: a single-center retrospective analysis

Kong,

Wang,

Wang

et al. 2023

Clin Rheumatol

View full text Add to dashboard Cite

Tubulointerstitial damage and interstitial immune cell phenotypes are useful predictors for renal survival and relapse in antineutrophil cytoplasmic antibody-associated vasculitis

Cited by 13 publications

References 33 publications

Renal Tissue miRNA Expression Profiles in ANCA-Associated Vasculitis—A Comparative Analysis

Renal Tissue miRNA Expression Profiles in ANCA-Associated Vasculitis—A Comparative Analysis

Early Renal Recovery after the First Flare of Pauci-Immune Glomerulonephritis

The correlation of interstitial change with renal prognosis in patients with myeloperoxidase-ANCA-associated glomerulonephritis: a single-center retrospective analysis

Contact Info

Product

Resources

About