Tubular membrane bioreactors for biotechnological processes

Abstract

This article is an overview of bioreactors using tubular membranes such as hollow fibers or ceramic capillaries for cultivation processes. This diverse group of bioreactor is described here in regard to the membrane materials used, operational modes, and configurations. The typical advantages of this kind of system such as environments with low shear stress together with high cell densities and also disadvantages like poor oxygen supply are summed up. As the usage of tubular membrane bioreactors is not restricted to a certain organism, a brief overview of various applications covering nearly all types of cells from prokaryotic to eukaryotic cells is also given here.

Ceramic tubular MOF hybrid membrane fabricated through in situ layer‐by‐layer self‐assembly for nanofiltration

“…It should be emphasized that compared with the polymer substrates, ceramic substrates have advantages of high‐temperature tolerance, well mechanical strength, and good antiswelling properties . Furthermore, tubular membrane modules were shown to be more effective than flat‐sheet arrangements for separation applications, because of their higher packing density . Therefore, tubular ceramic membranes will have bright application prospects.…”

Molecular Dynamics Study of Programmable Nanoporous Graphene

“…While simple in concept, membrane science is an ever evolving and expanding field, with new materials and designs constantly pushing the limits of current technology (Pellegrin et al 2012). Membranes are remarkably ubiquitous devices, in such diverse applications as liquid purification (Jaffrin 2008), gas separation (Bernardo et al 2009), and control of biological (Lee et al 2013c) and bioartificial processes (Wolff et al 2013). However, each of these procedures poses its own unique challenges to the basic concept of selective fluid flow.…”

Μελέτη Της Έμφραξης Μεμβρανών Σε Πιλοτική Μονάδα Βιοαντιδραστήρα

“…(Yoon, 2016). Οι επίπεδες μεμβράνες χρησιμοποιούνται κυρίως σε εργαστηριακή και πιλοτική κλίμακα ή μικρές μονάδες πλήρους κλίμακας (< 5.000 m 3 /d) και παρουσιάζουν το πλεονέκτημα ότι μπορούν εύκολα να καθαριστούν και να αντικατασταθούν (Lebrero et al, 2014;Cote et al, 2012 (Yoon, 2016;Wolff et al, 2013;Metcalf and Eddy, 2014). μεγάλη επιφάνεια ανά μονάδα όγκου της σχηματιζόμενης συστοιχίας (300-1.000 m 2 /m 3 ), ενώ η διάμετρος και το μήκος τους κυμαίνονται, αντίστοιχα, μεταξύ 100-300 mm και 1-1,5 m.…”