Tubular collagen scaffolds with radial elasticity for hollow organ regeneration

Versteegden, Luuk R.; Kampen, Kenny A. van; Janke, Heinz P.; Tiemessen, Dorien M.; Hoogenkamp, Henk R.; Hafmans, T.G.M.; Roozen, Edwin A.; Lomme, Roger M. L. M.; Goor, Harry van; Oosterwijk, Egbert; Feitz, W.F.J.; Kuppevelt, Toin H. Van; Daamen, Willeke F.

doi:10.1016/j.actbio.2017.02.005

Cited by 40 publications

(31 citation statements)

References 30 publications

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“…This bioprinted urethra demonstrated mechanical properties equivalent to native rabbit urethra, with cells maintaining 80% viability at 7 days and demonstrating active proliferation (52). Versteegden also reported on collagen scaffolds produced via 3D-printing, reproducing the elasticity and shape-recovery of human urethral tissue (53). Yu investigated 3D-printed polycaprolactone (PCL) scaffolds and culture of human fibroblast cells for potential use as a surrogate for tunica albuginea (54) and Oh et al successfully cultured human aortic smooth muscle and umbilical vein endothelial cells over 3D-printed PCL scaffolds as a potential tissue-engineered corpus cavernosum graft (63).…”

Section: Patient-specific Prostheses and Bioprintingmentioning

confidence: 86%

Innovation in Urology: Three Dimensional Printing and Its Clinical Application

2020

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Three-dimensional (3D) printing allows rapid prototyping of novel equipment as well as the translation of medical imaging into tangible replicas of patient-specific anatomy. The technology has emerged as a versatile medium for innovation in medicine but with ever-expanding potential uses, does 3D printing represent a valuable adjunct to urological practice? We present a concise systematic review of articles on 3D printing within urology, outlining proposed benefits and the limitations in evidence supporting its utility. We review publications prior to December 2019 using guidelines outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. Of 117 identified articles, 67 are included highlighting key areas of research as the use of patient-specific models for patient education, surgical planning, and surgical training. Further novel applications included printed surgical tools, patient-specific surgical guides, and bioprinting of graft tissues. We conclude to justify its adoption within standard practice, further research is required demonstrating that use of 3D printing can produce; direct and measurable improvements in patient experience, consistent evidence of superior surgical outcomes or simulation which surpasses existing means' both in fidelity and enhancement of surgical skills. Although exploration of 3D printing's urological applications remains nascent, the seemingly limitless scope for innovation and collaborative design afforded by the technology presents undeniable value as a resource and assures a place at the forefront of future advances.

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Section: Patient-specific Prostheses and Bioprintingmentioning

confidence: 86%

Innovation in Urology: Three Dimensional Printing and Its Clinical Application

2020

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“…Multifunctionality: The physiological functions of tubular organs, such as morphological changes due to peristalsis, their physical characteristics, such as elasticity [23], and their anatomy, such as the arrangement of muscle fibers, make multifunctionality critical in the design criteria for robotic implant platforms. The esophagus presents two types of muscles, arranged in layers, an inner circular layer and an outer longitudinal layer [24].…”

Section: A Design Requirementsmentioning

confidence: 99%

Axially and Radially Expandable Modular Helical Soft Actuator for Robotic Implantables

Perez-Guagnelli

Nejus

et al. 2018

2018 IEEE International Conference on Robotics and Automation (ICRA)

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“…Tubular organs are characterized by complex structure and mechanical properties that are responsible for specific functions [8,9]. Development in tissue engineering in recent years and promising results, showed an urgent need for investigating more complex constructs that are designed in special and accurate manner [10][11][12]. This brings additional challenges in tissue engineering in order to construct complete organs by using combinations of various cells along with the support material systems.…”

Section: Introductionmentioning

confidence: 99%

4-Axis printing microfibrous tubular scaffold and tracheal cartilage application

Lei

Guo

et al. 2019

Sci. China Mater.

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Long-segment defects remain a major problem in clinical treatment of tubular tissue reconstruction. The design of tubular scaffold with desired structure and functional properties suitable for tubular tissue regeneration remains a great challenge in regenerative medicine. Here, we present a reliable method to rapidly fabricate tissueengineered tubular scaffold with hierarchical structure via 4axis printing system. The fabrication process can be adapted to various biomaterials including hydrogels, thermoplastic materials and thermosetting materials. Using polycaprolactone (PCL) as an example, we successfully fabricated the scaffolds with tunable tubular architecture, controllable mesh structure, radial elasticity, good flexibility, and luminal patency. As a preliminary demonstration of the applications of this technology, we prepared a hybrid tubular scaffold via the combination of the 4-axis printed elastic poly(glycerol sebacate) (PGS) bio-spring and electrospun gelatin nanofibers. The scaffolds seeded with chondrocytes formed tubular mature cartilage-like tissue both via in vitro culture and subcutaneous implantation in the nude mouse, which showed great potential for tracheal cartilage reconstruction.

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Tubular collagen scaffolds with radial elasticity for hollow organ regeneration

Cited by 40 publications

References 30 publications

Innovation in Urology: Three Dimensional Printing and Its Clinical Application

Innovation in Urology: Three Dimensional Printing and Its Clinical Application

Axially and Radially Expandable Modular Helical Soft Actuator for Robotic Implantables

4-Axis printing microfibrous tubular scaffold and tracheal cartilage application

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