Tubular Breast Cancer Experience at Washington University: A Review of the Literature

Holland, Derek; Boucher, Leslie D.; Mortimer, Joanne

doi:10.3816/cbc.2001.n.023

Cited by 29 publications

(31 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The term tubular carcinoma is used only to indicate the pure forms, where a tubular component of more than 90% is present [1]. This particular subtype of invasive ductal carcinoma occurs with a prevalence of 1%-10% of all mammary adenocarcinomas [2][3][4][5][6], with a reported mortality of 2% [7].…”

Section: Introductionmentioning

confidence: 99%

Tubular carcinoma of the breast: pathological, clinical, and ultrasonographic findings. A review of the literature

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Tubular carcinoma of the breast: pathological, clinical, and ultrasonographic findings. A review of the literature

et al. 2006

View full text Add to dashboard Cite

show abstract

“…When comparing IDC-NOS to medullary, tubular and mucinous types, no statistically significant differences were found in the local-regional failure rate among the four groups. In total, 31% of TCs and up to 37.5% of ACCs that had been treated with excision only developed local recurrence [33,47,79].…”

Section: Poor Prognosis Ers Negativementioning

confidence: 99%

Breast carcinoma—rare types: review of the literature

Yerushalmi¹,

Hayes

Gelmon³

2009

Annals of Oncology

123

100

View full text Add to dashboard Cite

Invasive breast cancer is a heterogeneous disease in its presentation, pathological classification and clinical course. However, there are more than a dozen variants which are less common but still very well defined by the World Health Organization (WHO) classification. The rarity of many of these neoplasms does not allow large or randomized studies to define the optimal treatment. Many of the descriptions of these cancers are from case reports and small series. Our review brings updated information on 16 epithelial subtypes as classified by the WHO system with a very concise histopathology description and parameters helpful in the clinic. The aim of our review is to provide a tool for breast cancer caregivers which will enable a better understanding of the disease and its optimal approach to therapy. This may also stand as a clinical framework for a future understanding of these rarer breast cancers when gene analysis work is reported.

show abstract

“…A myoepithelial layer is absent in both tubular carcinoma and MGA; however, MGA is invested by a basement membrane, which can be identified with the use of immunohistochemical stains (and special stains). Importantly, virtually all tubular carcinomas and well-differentiated ductal carcinomas show diffuse and strong reactivity for ER and PR, 21,23 whereas MGA is ER and PR negative.…”

Section: Tubular Carcinomamentioning

confidence: 99%

“…[20][21][22][23][24][25][26] The clinical presentation of tubular carcinoma is not different from that of conventional invasive ductal carcinoma, with the exception that tubular carcinoma is more likely to be detected on screening imaging than as a palpable abnormality and is more often multifocal. [21][22][23]27 Compared with conventional invasive ductal carcinomas, tubular carcinomas are typically smaller in size, with most tumors measuring 1 cm or less.…”

Section: Tubular Carcinomamentioning

confidence: 99%

“…Ductal carcinoma in situ is associated with tubular carcinoma in approximately 50% to 70% of cases and is usually micropapillary, with low to intermediate nuclear grade. 20,21,26,[28][29][30]37,38 Tubular carcinoma is frequently associated with atypical lobular hyperplasia/lobular carcinoma in situ and columnar cell alterations. 23,30,32,37,39 Columnar cell lesions were seen in association with tubular carcinoma in 93% of cases in one study.…”

Section: Tubular Carcinomamentioning

confidence: 99%

See 1 more Smart Citation

Small Glandular Proliferations of the Breast With Absent or Attenuated Myoepithelial Reactivity by Immunohistochemistry: A Review Focusing on the Differential Diagnosis and Interpretative Pitfalls

Ginter

Shin²,

D’Alfonso³

2016

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Context.—Small glandular proliferations of the breast encompass a variety of benign, atypical, and malignant lesions that show some overlapping morphologic features. Myoepithelial stains are frequently used in the workup of these lesions in order to rule out or establish a diagnosis of invasive carcinoma. Some benign lesions show absent or diminished myoepithelial staining, and may represent an interpretative pitfall, particularly in small core biopsy samples. Objective.—To review small glandular proliferations of the breast that show absent or diminished staining with myoepithelial immunohistochemical markers. Data Sources.—The study comprised a review of published literature and clinical case material. Conclusions.—The interpretation of myoepithelial stains in small glandular proliferations of the breast can, on some occasions, represent a challenge in diagnosing these lesions. Recognition of the key histopathologic features and immunohistochemical staining patterns of the entities in the differential diagnosis is crucial in their workup.

show abstract

Tubular Breast Cancer Experience at Washington University: A Review of the Literature

Cited by 29 publications

References 16 publications

Tubular carcinoma of the breast: pathological, clinical, and ultrasonographic findings. A review of the literature

Tubular carcinoma of the breast: pathological, clinical, and ultrasonographic findings. A review of the literature

Breast carcinoma—rare types: review of the literature

Small Glandular Proliferations of the Breast With Absent or Attenuated Myoepithelial Reactivity by Immunohistochemistry: A Review Focusing on the Differential Diagnosis and Interpretative Pitfalls

Contact Info

Product

Resources

About