Tuboovarian abscess caused by Candida glabrata in a febrile neutropenic patient

Mikamo, Hiroshige; Ninomiya, Mitsuo; Tamaya, Teruhiko

doi:10.1007/s10156-003-0246-6

Cited by 7 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 286 patients were described. There were 52 papers describing 139 single cases, one open-label, noncomparative, clinical trial involving a total of 29 patients and one randomized clinical trial involving a total of 118 patients [ 43 , 44 , 45 , 46 , 47 , 54 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , …”

Section: Resultsmentioning

confidence: 99%

Antifungal Combinations against Candida Species: From Bench to Bedside

Fioriti

Brescini

Pallotta

et al. 2022

JoF

View full text Add to dashboard Cite

Candida spp. is the major causative agent of fungal infections in hospitalized patients and the fourth most common cause of nosocomial bloodstream infection (BSI). The availability of standardized methods for testing the in vitro activity of antifungals along with the expanding of antifungal armamentarium, the rising of drug-resistance and the persistence of a high mortality rate in systemic candidiasis have led to an increased interest in combination therapy. Therefore, we aimed to review the scientific literature concerning the antifungal combinations against Candida. A literature search performed in PubMed yielded 92 studies published from 2000 to 2021: 29 articles referring to in vitro studies, six articles referring to either in vitro and in vivo (i.e., animal models) studies and 57 clinical articles. Pre-clinical studies involved 735 isolates of Candida species and 12 unique types of antifungal combination approaches including azoles plus echinocandins (19%), polyenes plus echinocandins (16%), polyenes plus azoles (13%), polyenes plus 5-flucytosine ([5-FC], 13%), azoles plus 5-FC (11%) and other types of combinations (28%). Results varied greatly, often being species-, drug- and methodology-dependent. Some combinatorial regimens exerted a synergistic effect against difficult-to-treat Candida species (i.e., azoles plus echinocandins; polyenes plus 5-FC) or they were more effective than monotherapy in prevent or reducing biofilm formation and in speeding the clearance of infected tissues (i.e., polyenes plus echinocandins). In 283 patients with documented Candida infections (>90% systemic candidiasis/BSI), an antifungal combination approach could be evaluated. Combinations included: azoles plus echinocandins (36%), 5-FC-combination therapies (24%), polyenes plus azoles (18%), polyenes plus echinocandins (16%) and other types of combination therapy (6%). Case reports describing combination therapies yielded favorable response in most cases, including difficult-to-treat fungal infections (i.e., endocarditis, osteoarticular infections, CNS infections) or difficult-to-treat fungal pathogens. The only randomized trial comparing amphotericin-B deoxycholate (AMB) plus FLU vs. AMB alone for treatment of BSI in nonneutropenic patients showed that the combination trended toward improved success and more-rapid clearance from the bloodstream. In summary, antifungal combinations against Candida have produced great interest in the past two decades. To establish whether this approach can become a reliable treatment option, additional in vitro and clinical data are warranted.

show abstract

Section: Resultsmentioning

confidence: 99%

Antifungal Combinations against Candida Species: From Bench to Bedside

Fioriti

Brescini

Pallotta

et al. 2022

JoF

View full text Add to dashboard Cite

show abstract

“…However, weeks of antibiotic therapy did not result in resolution, and she improved only with the combination of ultrasound-guided drainage (to decompress the abscess and allow identification of the causative organism) and appropriate antimicrobial treatment (with the addition of antifungals to her therapy). Curiously, yeast is an opportunistic microorganism and is not known to cause severe infection and form abscesses unless the patient is immunocompromised 9,19 or has an IUD, as in two other case reports. 10,11 It is possible that the prolonged antibiotic therapy before transfer to our hospital could have suppressed the detection of bacteria in culture media.…”

Section: Discussionmentioning

confidence: 98%

“…7,8 TOA caused by a fungus has been described in only three case reports to date; in all three cases the causative organism was Candida glabrata, and the patients either had an IUD or were immunocomprised. [9][10][11] We report here a case of TOA caused by Candida albicans, in a non-diabetic 44-year-old woman with no apparent risk factors except morbid obesity.…”

Section: Introductionmentioning

confidence: 99%

Tubo-Ovarian Abscess Caused by Candida Albicans in an Obese Patient

Gurberg

Krishnamurthy

2015

Journal of Obstetrics and Gynaecology Canada

View full text Add to dashboard Cite

show abstract

“…Abscesses in the oviduct, 15 iliopsoas muscle, 16 epidural space, 17 and brain 18 have been reported in patients on MTX. However, no reports of cervical abscess treatment following MTX use in RA patients have been described.…”

Section: Discussionmentioning

confidence: 99%

Two cases of cervical abscess in rheumatoid arthritis patients

et al. 2005

View full text Add to dashboard Cite

The prognosis of rheumatoid arthritis (RA) has recently been improved, resulting in longer survival of patients. The incidence of oral diseases increases with age, particularly for periodontal disease and those involving tooth decay, even in normal healthy individuals. Patients with RA display increased incidence of oral diseases, and the use of steroids or methotrexate to treat RA increases susceptibility to infections, sometimes causing serious infections. We present here two cases of cervical abscesses in RA patients who underwent emergency surgery to treat oral infections due to the possibility of mediastinal inflammation.

show abstract

Tuboovarian abscess caused by Candida glabrata in a febrile neutropenic patient

Cited by 7 publications

References 10 publications

Antifungal Combinations against Candida Species: From Bench to Bedside

Antifungal Combinations against Candida Species: From Bench to Bedside

Tubo-Ovarian Abscess Caused by Candida Albicans in an Obese Patient

Two cases of cervical abscess in rheumatoid arthritis patients

Contact Info

Product

Resources

About