Abstract:Tuberous sclerosis (or tuberous sclerosis complex) is a multisystem disorder characterized by tumor‐like lesions (hamartomas) in the brain, skin, and other organs and is often associated with seizures and mental retardation. The major diagnostic features are facial angiofibromas, forehead plaques, ungual fibromas, hypomelanotic macules, shagreen patches, retinal astrocytic hamartomas, cortical tubers, subependymal nodules, subependymal giant cell astrocytomas, cardiac rhabdomyomas, renal angiomyolipomas, and p… Show more
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