Tuberculous Spondylitis: A Report of Different Clinical Scenarios and Literature Update

Lacerda, Catarina; Linhas, Rita; Duarte, Raquel

doi:10.1155/2017/4165301

Cited by 14 publications

(15 citation statements)

References 18 publications

(27 reference statements)

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“…Pharmacological treatment should be initiated as soon as the diagnosis is confrmed, with 2 months of HRZE (intensive phase) followed by 4 to 7 months of HR (continuation phase) but the duration of treatment remains controversial. Due to dificulties in assessing response and risk of relapse, most experts recommend 9 to 12 months of treatment, and in situations of slow radiological resolution as case 2, 12 to 24 months of treatment should be considered [6]. This case highligths the importance of early recognition of Pott´s disease, a rare and serious manifestation of TB infection, to prevent permanente neurological sequelae.…”

Section: Juniper Online Journal Of Case Studies Discussion and Conclusionmentioning

confidence: 96%

Untitled

2018

JOJCS

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Pott's disease (PD) or spinal tuberculosis is a rare condition which accounts for less than 1% of total tuberculosis (TB) cases and despite a progressive decline in the number of the cases of tuberculosis all over the world, still remains a significant cause of morbidity in this patients. We present the clinical case of a 79 year-old female that was admitted to our Internal Medicine Service to study a fever of unknown origin. Despite the extensive study realized, no focalization on infectious, neoplastic, inflammatory or lymphoproliferative etiologies was found and the patient was discharged for maintenance the study in external consult. 3 weeks later and with persistent complaints of low back pain, a CT scan of the column showed showed extensive process of spondylodiscitis with vertebral abscess. An abscess puncture was performed and microbiology cultures confirmed the diagnosis of TB. This case highligths the importance of early recognition of Pott´s disease, a rare and serious manifestation of TB infection,and its recognition helps to prevent permanent neurological sequelae and other phisycal damage.

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Section: Juniper Online Journal Of Case Studies Discussion and Conclusionmentioning

confidence: 96%

Untitled

2018

JOJCS

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“…Tubercular spondylitis is a common extra-pulmonary manifestation prevalent in India; it is associated with significant morbidity and most commonly involves the spine in immunocompromised patients such as people living with HIV (PLHIV) and diabetes [ 8 ]. Though TB spondylitis has a chronic course, it can be clinically unnoticed and can present acutely as compressive myelopathy, radiculopathy, or as a psoas abscess [ 9 ]. Pyogenic infection usually disseminates through vascular arcades in the spine; as a result, there is early involvement of the intervertebral discs and then the adjacent vertebral body.…”

Section: Discussionmentioning

confidence: 99%

Concurrent Presentation of Emphysematous Pyelonephritis, Emphysematous Osteomyelitis, and Psoas Abscesses

Neelakandan¹,

Viswanathan²,

Selvaraj³

et al. 2021

Cureus

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Emphysematous pyelonephritis (EPN) is an uncommon necrotizing infection commonly seen in people with diabetes. Emphysematous osteomyelitis (EOM) is a rare form of pyogenic osteomyelitis characterized by the presence of air in the bones. A combination of both these infections has been reported only thrice in the literature. We present the case of a middle-aged diabetic woman who had both these rare infections along with psoas abscesses, a phenomenon that has been described only once previously. The patient required prolonged hospitalization, surgical debridement and drainage, a double-J stent, and meropenem, and she subsequently achieved full recovery.

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“…The serum was taken, then put into the tube and stored in the refrigerator with a temperature of -70 o C. Measurements of TNF-α levels were performed by ELISA. The steps of TNF-α examination were as follows (1). Reagents preparation, samples and standard solutions as controls (2).…”

Section: Methodsmentioning

confidence: 99%

“…It is estimated that about onethird of the world's population has been infected by the Mycobacterium tuberculosis. The WHO data 2012 stated that Indonesia takes the fourth place in the world with the number of 0.40-0.50 million people with tuberculosis after India (2.0-2.5 million sufferers), China (0.9-1.1 million sufferers) and South Africa (0.40-0.60 million sufferers) 1 .…”

Section: Introductionmentioning

confidence: 99%

Changes in ARB Sputum Positivity, BMI and TNF-? Levels of Pulmonary TB Patients with ARB Positive During One-month Intensive Treatment

Samsuri¹

2020

IJFMT

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Backgoround: TNF-α plays a role in the occurrence of anorexia and weight loss in pulmonary tubercolusis (TB) patients. Evaluation of treatment response can be done with clinical, microbiological and radiological evaluation. In patients without cough, Body Mass Index (BMI) and TNF-α levels can be used to evaluate clinical treatment response. Objectives:The aim of the study is to measure the Acid Resistant Bacteria (ARB) sputum positivity decrease, TNF-α levels and increased BMI after 2 weeks and 4 weeks intensive treatment of pulmonary TB patients with new case of ARB positive. Methods:The sample size was 14 people with ARB positive pulmonary TB cases, consisting of 9 men and 5 women. It was done sputup smear, BMI and TNF-α examination before treatment, at week 2 and week 4 of intensive phase treatment Result: At the end of the second week, TNF-α levels decreased significantly compared to baseline TNF-α levels with p = 0.015. There was a non significant increase of BMI at the end of the second and fourth week with p = 0.309 and p = 0.270 respectively. The decrease in ARB sputum smear positivity at the end of the second week compared to the fourth week was not statistically significant with p = 0.157. There was a strong correlation between TNF-α and IMT levels before treatment with negative correlation, r = -0.702 and p = 0.005. Conclusion:Levels of TNF-α at the end of the second week decreased significantly compared to baseline TNF-α levels. There was a strong correlation between TNF-α levels and BMI prior to treatment.

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Tuberculous Spondylitis: A Report of Different Clinical Scenarios and Literature Update

Cited by 14 publications

References 18 publications

Untitled

Untitled

Concurrent Presentation of Emphysematous Pyelonephritis, Emphysematous Osteomyelitis, and Psoas Abscesses

Changes in ARB Sputum Positivity, BMI and TNF-? Levels of Pulmonary TB Patients with ARB Positive During One-month Intensive Treatment

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