Tuberculous Peripheral Lymphadenitis

Hooper, A. A.

doi:10.1002/bjs.1800590506

Cited by 65 publications

(55 citation statements)

References 15 publications

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“…Com prevalência de até 1,5% 2 , a tuberculose ainda é excessiva nesta parte do mundo, e o acometimento tuberculoso dos linfonodos é a forma mais comum de tuberculose extrapulmonar (responsável por 30-40% dos casos) 3 . Portanto, no exame inicial a tuberculose é atribuída como a causa subjacente na maioria dos casos de linfadenopatia 4,5 .…”

Section: Introductionunclassified

Children with significant cervical lymphadenopathy: clinicopathological analysis and role of fine-needle aspiration in Indian setup

Khan¹,

Wahab²,

Chana³

et al. 2008

J Pediatr (Rio J)

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ResumoObjetivo: Estudar o perfil clínico-patológico de crianças indianas com linfadenopatia cervical e o papel da citologia aspirativa por agulha fina com ênfase especial na tuberculose como causa. Resultados: A hiperplasia reativa foi o tipo mais comum de linfadenite, seguida da granulomatosa. Os linfonodos do triângulo posterior unilateral foram o grupo afetado com maior freqüência no grupo de linfadenopatia cervical tuberculosa. A aspiração por agulha fina, seguida da coloração de Ziehl-Neelsen, histopatologia e cultura em associação, obteve sucesso em realizar o diagnóstico em 85,7% dos casos de etiologia tuberculosa. Métodos Conclusões:A aspiração por agulha fina é uma ferramenta diagnóstica valiosa no tratamento de crianças com apresentação clínica de linfonodos cervicais aumentados. A técnica reduz a necessidade de procedimentos mais invasivos e dispendiosos, principalmente em países em desenvolvimento.Cultura e histopatologia, entretanto, devem ser consideradas em casos nos quais a citologia aspirativa por agulha fina não é diagnóstica.J Pediatr (Rio J). 2008;84(5):449-454: Linfadenopatia cervical, citologia aspirativa por agulha fina, crianças. AbstractObjective: To study the clinicopathological profile of children from India with cervical lymphadenopathy and the role of fine-needle aspiration cytology with special emphasis on tuberculosis as a cause. Methods:A total of 89 children in the age group of 10 months to 12 years, presenting to our hospital from April 2004 to March 2005, were included. All the patients underwent thorough clinical and investigational assessment vis-à-vis cervical lymphadenopathy. Outcome measurements included clinical status and ability of conventional tests to categorize different types of lymphadenopathy and their utility in diagnosing tubercular lymphadenitis. Interobserver variability was analyzed measuring kappa test and was found to be in agreement. Results:Reactive hyperplasia was the most common type of lymphadenitis, followed by granulomatous involvement. Unilateral posterior triangle lymph nodes were the most commonly affected in the tubercular cervical lymphadenopathy group. Fine-needle aspiration followed by Ziehl-Neelsen staining, histopathology and culture in combination were able to perform the diagnosis in 85.7% of cases affected with tubercular etiology. Conclusions:Fine-needle aspiration is a valuable diagnostic tool in the management of children with the clinical presentation of enlarged cervical lymph nodes. The technique reduces the need for more invasive and costly procedures, especially in a Third World country. Culture and histopathology, however, should be considered in cases where repeated fine-needle aspiration cytology is non-diagnostic.J Pediatr (Rio J). 2008;84(5):449-454: Cervical lymphadenopathy, fine-needle aspiration cytology, children.

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Section: Introductionunclassified

Children with significant cervical lymphadenopathy: clinicopathological analysis and role of fine-needle aspiration in Indian setup

Khan¹,

Wahab²,

Chana³

et al. 2008

J Pediatr (Rio J)

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“…Extra-pulmonary TB is also much higher in Asians than in the Caucasian population (Finch et al, 1991;WHO, 2002). Tuberculous lymphadenitis (TB-L) is the most common form of extra-pulmonary TB, accounting for 30-40 % of TB cases (Hooper, 1972;Krishanaswami et al, 1972;Appling & Miller, 1981). TB-L also occurs with an increased frequency in patients with human immunodeficiency virus (HIV) (Finfer et al, 1991;Slavik et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Assessment of possible tuberculous lymphadenopathy by PCR compared to non-molecular methods

Pahwa

Hedau

Jain

et al. 2005

Journal of Medical Microbiology

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Tuberculosis is a major public health problem in India and other developing countries and has formed a lethal partnership with AIDS. It often presents a diagnostic challenge especially when clinical presentation is suggestive but bacteriological proof is lacking. The objective of this study was to compare the various diagnostic techniques in clinically suspected cases of tubercular lymph nodes and to find a suitable, cost-effective but sensitive and specific method for diagnosis. A total of 100 cases were recruited for the study. Fine needle aspiration cytology was done in all cases and the smears prepared were processed for Giemsa, Ziehl-Neelsen's, Kinyoun and Papanicolaou stains. Parts of the aspirated materials were assessed by fluorescent staining, culture and PCR. Seventyfour percent of aspirates were positive by fluorescent stain while only 22 % were positive by culture. PCR could be performed in 55 cases, out of which 22 (40 %) were positive. When compared to culture, the sensitivity and specificity of PCR were found to be 89 . 5 % and 86 . 1 %, respectively. Fluorescent stain was found to be the most sensitive (81 . 8 %) of the conventional methods but showed poor specificity (28 . 2 %). Interestingly, PCR detected 80 % of smear-negative but culturepositive cases.

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“…2 Tuberculous lymphadenitis is the most common presentation of extrapulmonary tuberculosis, accounting for 30-40% of cases in reported series. 3 The onset of tuberculous lymphadenitis is insidious. Patients present with enlarged, usually painless lymph nodes, most commonly affecting the cervical region.…”

Section: Discussionmentioning

confidence: 99%

“…With prevalence as high as 1.5%, 2 tuberculosis is still rampant in this part of the world and the tuberculous involvement of lymph nodes is the most common form of extrapulmonary tuberculosis (responsible for 30-40% of cases). 3 Therefore, on initial examination tuberculosis is attributed as the underlying cause in most cases of lymphadenopathy. 4,5 Tuberculous involvement of superficial lymph nodes is common presentation of extrapulmonary tuberculosis in children.…”

Section: Introductionmentioning

confidence: 99%

Crianças com linfadenopatia cervical significativa: análise clínico-patológica e papel da aspiração por agulha fina no contexto indiano

Khan¹,

Wahab²,

Chana³

et al. 2008

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objective: To study the clinicopathological profile of children from India with cervical lymphadenopathy and the role of fine-needle aspiration cytology with special emphasis on tuberculosis as a cause. Methods:A total of 89 children in the age group of 10 months to 12 years, presenting to our hospital from April 2004 to March 2005, were included. All the patients underwent thorough clinical and investigational assessment vis-à-vis cervical lymphadenopathy. Outcome measurements included clinical status and ability of conventional tests to categorize different types of lymphadenopathy and their utility in diagnosing tubercular lymphadenitis. Interobserver variability was analyzed measuring kappa test and was found to be in agreement.Results: Reactive hyperplasia was the most common type of lymphadenitis, followed by granulomatous involvement. Unilateral posterior triangle lymph nodes were the most commonly affected in the tubercular cervical lymphadenopathy group. Fine-needle aspiration followed by Ziehl-Neelsen staining, histopathology and culture in combination were able to perform the diagnosis in 85.7% of cases affected with tubercular etiology. Conclusions:Fine-needle aspiration is a valuable diagnostic tool in the management of children with the clinical presentation of enlarged cervical lymph nodes. The technique reduces the need for more invasive and costly procedures, especially in a Third World country. Culture and histopathology, however, should be considered in cases where repeated fine-needle aspiration cytology is non-diagnostic.J Pediatr (Rio J). 2008;84(5):449-454: Cervical lymphadenopathy, fine-needle aspiration cytology, children.

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Tuberculous Peripheral Lymphadenitis

Abstract: Tuberculous peripheral lymphadenitis is still a common and often poorly treated manifestation of tuberculosis. One hundred and eighteen cases are reviewed, and the problems of diagnosis and management are considered together with the causes of failure of treatment.

Cited by 65 publications

References 15 publications

Children with significant cervical lymphadenopathy: clinicopathological analysis and role of fine-needle aspiration in Indian setup

Children with significant cervical lymphadenopathy: clinicopathological analysis and role of fine-needle aspiration in Indian setup

Assessment of possible tuberculous lymphadenopathy by PCR compared to non-molecular methods

Crianças com linfadenopatia cervical significativa: análise clínico-patológica e papel da aspiração por agulha fina no contexto indiano

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